Intensive and comprehensive studyon OXA-type carbapenemase producing Acinetobacter species

• Project/Area Number: 22591113
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Infectious disease medicine
• Research Institution: Toho University
• Principal Investigator: ISHII Yoshikazu 東邦大学, 医学部, 教授 (90246695)
• Co-Investigator(Kenkyū-buntansha): TATEDA Kazuhiro 東邦大学, 医学部, 教授 (20236558)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: アシネトバクター属菌 / カルバペネマーゼ / 耐性菌サーベイランス / 感染症 / 抗生物質 / カルバペネム耐性 / β－ラクタマーゼ / β-ラクタマーゼ / βラクタマーゼ

Research Abstract

A detection system for factors that reduce carbapenem susceptibility in Acinetobacterspecies was constructed using an immunochromatographical technique. The sensitivity and specificity of the constructed system were 81.3% and 92.5% respectively. The reduce-susceptibility factors were detected in 598 Japanese clinical isolates of Acinetobacterspecies. OXA-type carbapenemases were detected in A. baumanniiand metallo-beta-lactamases in non-baumannii Acinetobacter. Isolates with reduced antibiotic susceptibility belonged to international clone of pandemic multidrug resistant A. baumannii. We also succeeded in obtaining X-ray crystal structure data of OXA-24 and the detailed kinetic parameters of OXA-23.

Research Products

• [Journal Article] Effects of slow-releasing colistin microspheres on endotoxin-induced sepsis (2013)
  • Author(s): Nanjo Y, Ishii Y, Kimura S, Fukami T, Mi zoguchi M, Suzuki T, Tomono K, Akasaka Y, Ishii T, Takahashi K, Tateda K, Yamaguchi K
  • Journal Title: J Infect Chemother
  • NAID: 10031194397
  • Peer Reviewed
• [Journal Article] Efficacies of calcium-EDTA in combination with imipenem in a murine model of sepsis caused by Escherichia coliwith NDM-1 β-lactamase (2013)
  • Author(s): Yoshizumi A, Ishii Y, Livermore DM, Woodford N, Kimura S, Saga T, Harada S, Yamaguchi K, Tateda K
  • Journal Title: J Infect Chemother
  • Peer Reviewed
• [Journal Article] Diversity of plasmid replicons encoding the bla_CMY-2gene in broad- spectrum cephalosporin-resistant Escherichia colifrom livestock animals in Japan (2013)
  • Author(s): Hiki M, Usui M, Kojima A, Ozawa M, Ishii Y, Asai T
  • Journal Title: Foodborne Pathog Dis Volume: 10 Pages: 243-249
  • Peer Reviewed
• [Journal Article] Evaluation of Camellia sinensis Catechins as a Swine Antimicrobial Feed Additive that does not Cause Antibiotic Resistance (2013)
  • Author(s): Ohno A, Kataoka S, Ishii Y, Terasaki T, Kiso M, Okubo M, Yamaguchi K, Tateda K
  • Journal Title: Microbes Environ Volume: 28 Pages: 81-86
  • NAID: 10031138547
  • Peer Reviewed
• [Journal Article] Effects of slow-releasing colistin microspheres on endotoxin-induced sepsis (2013)
  • Author(s): Nanjo Y
  • Journal Title: J Infect Chemother Volume: 18 Issue: 4 Pages: 683-690
  • DOI: 10.1007/s10156-012-0544-y
  • Peer Reviewed
• [Journal Article] Efficacies of calcium-EDTA in combination with imipenem in a murine model of sepsis caused by Escherichia coli with NDM-1 β-lactamase (2013)
  • Author(s): Yoshizumi A
  • Journal Title: J Infect Chemother Volume: 18 Issue: 5 Pages: 992-995
  • DOI: 10.1007/s10156-012-0528-y
  • Peer Reviewed
• [Journal Article] Genotyping of skin and soft tissue infection (SSTI)-associated methicillin-resistant Staphylococcus aureus (MRSA) strains among outpatients in a teaching hospital in Japan: application of a phage-open reading frame typing (POT) kit (2013)
  • Author(s): Maeda T
  • Journal Title: J Infect Chemother Volume: 18 Issue: 6 Pages: 906-914
  • DOI: 10.1007/s10156-012-0506-4
  • Peer Reviewed
• [Journal Article] Genotyping of skin and soft tissue infection (SSTI)-associated methicillin-resistant Staphylococcus aureus(MRSA) strains among outpatients in a teaching hospital in Japan: application of a phage-open reading frame typing (POT) kit (2012)
  • Author(s): Maeda T, Saga T, Mi yazaki T, Kouyama Y, Harada S, Iwata M, Yoshizawa S, Kimura S, Ishii Y, Urita Y, Sug i mo t o M, Ya ma guchi K, Ta t e da K
  • Journal Title: J Infect Chemother Volume: 18 Pages: 906-914
  • NAID: 10031143894
  • Peer Reviewed
• [Journal Article] A peptide based on homologous sequences of the β-barrel assembly machinery component BamD potentiates antibiotic susceptibility of Pseudomonas aeruginosa (2012)
  • Author(s): Mori N, Ishii Y, Tateda K, Kimura S, Kouyama Y, Inoko H, Mitsunaga S, Yamaguchi K, Yoshihara E
  • Journal Title: J Antimicrob Chemother Volume: 67 Pages: 2173-2181
  • Peer Reviewed
• [Journal Article] Molecular characterization of carbapenem-non-susceptible Acinetobacterspp. in Japan: predominance of multidrug-resistant Acinetobacter baumanniiclonal complex 92 and IMP-type metallo-β-lactamase-producing non-baumannii Acinetobacterspecies (2012)
  • Author(s): Kouyama Y, Harada S, Ishii Y, Saga T, Yoshizumi A, Tateda K, Yamaguchi K
  • Journal Title: J Infect Chemother Volume: 18 Pages: 522-528
  • Peer Reviewed
• [Journal Article] Virulence-suppressing effects of linezolid on methicillin-resistant Staphylococcus aureus: possible contribution to early defervescence (2012)
  • Author(s): Yoshizawa S, Tateda K, Saga T, Ishii Yand Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 56 Pages: 1744-1748
  • Peer Reviewed
• [Journal Article] In vitro combination effects of aztreonam and aminoglycoside against multidrug- resistant Pseudomonas aeruginosain Japan (2012)
  • Author(s): Araoka H, Baba M, Tateda K, Ishii Y, Oguri T, Okuzumi K, Oishi T, Mori S, Mitsuda T, Moriya K, Nakamori Y, Ohmagari N, Yamaguchi K, Yoneyama A and ABX Combination Therapy Study Group
  • Journal Title: Jpn J Infect Dis Volume: 65 Pages: 84-87
  • Peer Reviewed
• [Journal Article] Molecular characterization of carbapenem-non-susceptible Acinetobacter spp.in Japan : predominance of multidrug-resistant Acinetobacter baumannii clonal complex 92 and IMP-type metallo-ss-lactamase-producing non-baumannii Acinetobacter species (2012)
  • Author(s): Kouyama Y, Harada S, Ishii Y, Saga T, Yoshizumi A, Tateda K, Yamaguchi K
  • Journal Title: J Infect Chemother Volume: 18(印刷中)
  • Peer Reviewed
• [Journal Article] Virulence-Suppressing Effects of Linezolid on Methicillia-Resistant Staphylococcus aureus : Possible Contribution to Early Defervescence (2012)
  • Author(s): Yoshizawa S, Tateda K, Saga T, Ishii Y, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 56 Pages: 1744-1748
  • Peer Reviewed
• [Journal Article] In vitro combination effects of aztreonam and aminoglycoside against multidrug-resistant Pseudomonas aeruginosa in Japan (2012)
  • Author(s): Araoka H, Baba M, Tateda K, Ishii Y, Oguri T, Okuzumi K, Oishi T, Mori S, Mitsuda T, Moriya K, Nakamori Y, Ohmagari N, Yamaguchi K, Yoneyama A., ABX Combination Therapy Study Group
  • Journal Title: Jpn J Infect Dis Volume: 65 Pages: 84-87
  • NAID: 40019139509
  • Peer Reviewed
• [Journal Article] Chromosomal integration and location on IncT plasmids of the blaCTXM-2 gene in Proteus mirabilis clinical isolates (2012)
  • Author(s): Harada S, Ishii Y, Saga T, Kouyama Y, Tateda K, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 56 Pages: 1093-1096
  • Peer Reviewed
• [Journal Article] In vitro and in vivo antibacterial activity of modithromycin against streptococci and Haemophilus influenzae (2011)
  • Author(s): Sato T, Kawai Y, Matsuda H, Tateda K, Kimura S, Ishii Y, Yamaguchi K and Gotoh N
  • Journal Title: J. Antimicrob. Chemother Volume: 66 Pages: 1547-1554
  • Peer Reviewed
• [Journal Article] Roles of Pseudomonsa aeruginosaautoinducers and their degradation products, teramic acids, in bacterial survival and behavior in ecological niches (2011)
  • Author(s): Hosono Honda N, Kimura S, Tateda K, Horikawa M, Ueda C, Ishii Y, Ishiguro M, Miyairi S and Yamaguchi K
  • Journal Title: Microbes Environment Volume: 26 Pages: 160-164
  • Peer Reviewed
• [Journal Article] Familial spread of a virulent clone of Klebsiella pneumoniaecausing primary liver abscess (2011)
  • Author(s): Harada S, Tateda K, Mitsui H, Hattori Y, Okubo M, Kimura S, Sekigawa K, Kobayashi K, Hashimoto N, Itoyama S, Nakai T, Suzuki T, Ishii Y and Yamaguchi K
  • Journal Title: J Clin Microbiol Volume: 49 Pages: 2354-2356
  • Peer Reviewed
• [Journal Article] In Vitro Intracellular Activity and In Vivo Efficacy of Modithromycin, a Novel Bicyclolide, against Legionella pneumophila (2011)
  • Author(s): Sato T, Tateda K, Kimura S, Ishii Y and Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Pages: 1594-1597
  • Peer Reviewed
• [Journal Article] In Vitro Antibacterial Activity of Modithromycin, a Novel 6,11-Bridged Bicyclolide, against Respiratory Pathogens, Including Macrolide-Resistant Gram-Positive Cocci (2011)
  • Author(s): Sato T, Tateda K, Kimura S, Iwata M, Ishii Yand Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Pages: 1588-1593
  • Peer Reviewed
• [Journal Article] Pravastatin inhibits farnesol production in Candida albicans and improves survival in a mouse model of systemic candidiasis (2011)
  • Author(s): Tashiro M, Kimura S, Tateda K, Saga T, Ohno A, Ishii Y, Izumikawa K, Tashiro T, Kohno S and Yamaguchi K
  • Journal Title: Med Mycol Volume: 50 Pages: 353-360
  • Peer Reviewed
• [Journal Article] Familial spread of a virulent clone of Klebsiella pneumoniae causing primary liver abscess (2011)
  • Author(s): Harada S, Tateda K, Mitsui H, Hattori Y, Okubo M, Kimura S, Sekigawa K, Kobayashi K, Hashimoto N, Itoyama S, Nakai T, Suzuki T, Ishii Y, Yamaguchi K
  • Journal Title: J Clin Microbiol Volume: 49 Pages: 2354-2356
  • Peer Reviewed
• [Journal Article] In vitro and in vivo antibacterial activity of modithromycin against streptococci and Haemophilus influenzae (2011)
  • Author(s): Sato T, Kawai Y, Matsuda H, Tateda K, Eimura S, Ishii Y, Yamaguchi K, Gotoh N
  • Journal Title: J.Antimicrob.Chemother. Volume: 66 Pages: 1547-1554
  • Peer Reviewed
• [Journal Article] Roles of Pseudomonsa aeruginosa autoinducers and their degradation products, teramic acids, in bacterial survival and behavior in ecological niches (2011)
  • Author(s): Hosono-Honda N, Kimura S, Tateda K, Horikawa M, Ueda C, Ishii Y, Ishiguro M, Miyairi S, Yamaguchi K
  • Journal Title: Microbes Environment Volume: 26 Pages: 160-164
  • Peer Reviewed
• [Journal Article] Evaluation of antimicrobial susceptibility for ss-lactams against clinical isolates from 51 medical centers in Japan (2008) (2011)
  • Author(s): Ishii Y, Ueda C, Kouyama Y, Tateda K, Yamaguchi K, the Japan Antimicrobial Resistance Surveillance Participants Group
  • Journal Title: Diagn Microbiol Infect Dis Volume: 69 Pages: 443-448
  • Peer Reviewed
• [Journal Article] The residues that make Toho-1 an extended-spectrum ss-lactamase : roles of Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 (2011)
  • Author(s): Shimizu-Ibuka A, Oishi M, Yamada S, Ishii Y, Mura K, Sakai H, Matsuzawa H
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Pages: 284-290
  • Peer Reviewed
• [Journal Article] In vitro antibacterial activity of modithromycin, a novel 6, 11-bridged bicyclolide, against respiratory pathogens, including macrolide-resistant Gram-positive cocci. (2011)
  • Author(s): Sato T, Tateda K, Kimura S, Iwata M, Ishii Y, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Pages: 1588-1593
  • Peer Reviewed
• [Journal Article] In vitro intracellular activity and in vivo efficacy of modithromycin, a novel bicyclolide, against Legionella pneumophila (2011)
  • Author(s): Sato T, Tateda K, Kimura S, Ishii Y, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Pages: 1594-1597
  • Peer Reviewed
• [Journal Article] ブレイクポイント・チェッカーボードプレートによる多剤耐性緑膿菌感染症に対する治療薬選択のためのスコア化による評価 (2011)
  • Author(s): 小栗豊子, 石井良和, 三澤成毅, 舘田一博, 奥住捷子, 吉田敦, 塚原みゆき, 大石毅, 馬場勝, 米山彰子, 住友みどり, 満田年宏, 森慎一郎, 柴山明義, 中森祥隆, 後藤美江子, 森屋恭爾, 佐藤智明, 大曲貴夫, 山口恵三
  • Journal Title: 日本化学療法学会雑誌 Volume: 59 Pages: 172-176
  • NAID: 10027817249
  • Peer Reviewed
• [Journal Article] 2001年～2006年臨床分離株に対するtazobactam/piperacillinの抗菌活性 (2011)
  • Author(s): 山口恵三, 石井良和, 伊藤喜久, 賀来満夫, 山本達男, 小林芳夫, 近藤成美, 馬場尚志, 一山智, 山中喜代治, 草野展周, 宮本仁志, 松本哲朗, 河野茂
  • Journal Title: 日本化学療法学会雑誌 Volume: 59 Pages: 177-187
  • NAID: 10027817260
  • Peer Reviewed
• [Journal Article] Roles of residues Cys69, Asn104, Phe160, Gly232, Ser237, and Asp240 in extended-spectrum β-lactamase Toho-1 (2010)
  • Author(s): Shimizu-Ibuka A, Oishi M, Yamada S, Ishii Y, Mura K, Sakai H and Matsuzawa H
  • Journal Title: Antimicrob Agents Chemother Volume: 55 Pages: 284-290
  • Peer Reviewed
• [Journal Article] Rapidly spreading CTX-M-type β-lactamase-producing Proteus mirabilisin Japan (2010)
  • Author(s): Kanayama A, Iyoda T, Matsuzaki K, Saika T, Ikeda F, Ishii Y, Yamaguchi K and Kobayashi I
  • Journal Title: Int J Antimicrob Agents Volume: 36 Pages: 340-342
  • Peer Reviewed
• [Journal Article] Anti-Clostridium difficilepotential of tetramic acid derivatives from Pseudomonas aeruginosaquorum-sensing autoinducers (2010)
  • Author(s): Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Nomura K, Yamada K, Suematsu T, Inoue Y, Ishiguro M, Miyairi S and Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 54 Pages: 683-688
  • Peer Reviewed
• [Journal Article] The catalytic efficiency k_cat/K_m of the class A β-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog (2010)
  • Author(s): Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H and Miyano M
  • Journal Title: Biochim Biophys Acta Volume: 1804 Pages: 684-691
  • Peer Reviewed
• [Journal Article] Sequential changes of Legionellaantigens and bacterial load in the lungs and urines of a mouse model of pneumonia (2010)
  • Author(s): Chen Y, Tateda K, Fujita K, Ishii T, Ishii Y, Kimura S, Saga T, Annaka T, Yamada S, Zhao L, Li S, Azuma A, Gemma A, Kudoh S and Yamaguchi K
  • Journal Title: Diagn Microbiol Infect Dis Volume: 66 Pages: 253-260
  • Peer Reviewed
• [Journal Article] Sequential changes of Legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia (2010)
  • Author(s): Chen Y, Tateda K, Fujita K, Ishii T, Ishii Y, Kimura S, Saga T, Annaka T, Yamada S, Zhao L, Li S, Azuma A, Gemma A, Kudoh S, Yamaguchi K
  • Journal Title: Diagn Microbiol Infect Dis Volume: 66 Pages: 253-260
  • Peer Reviewed
• [Journal Article] The catalytic efficiency kcat/Km of the class A β-lactamase Toho-1 correlates with the thermal stability of its catalytic intermediate analog (2010)
  • Author(s): Nitanai Y, Shimamura T, Uchiyama T, Ishii Y, Takehira M, Yutani K, Matsuzawa H, Miyano M
  • Journal Title: Biochim Biophys Acta Volume: 1084 Pages: 684-691
  • Peer Reviewed
• [Journal Article] Anti-Clostridium difficile potential of tetramic acid derivatives from Pseudomonas aeruginosa quorum-sensing autoinducers (2010)
  • Author(s): Ueda C, Tateda K, Horikawa M, Kimura S, Ishii Y, Nomura K, Yamada K, Suematsu T, Inoue Y, Ishiguro M, Miyairi S, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 54 Pages: 683-688
  • Peer Reviewed
• [Journal Article] Chromosomally encoded bla_<CMY-2> located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinicalisolate (2010)
  • Author(s): Harada S, Ishii Y, Saga T, Tateda K, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 54 Pages: 3545-3550
  • Peer Reviewed
• [Journal Article] In vitro potentiation of carbapenems with ME1071, a novel metallo-β-lactamase inhibitor, against metallo-β-lactamase- producing Pseudomonas aeruginosa clinical isolates (2010)
  • Author(s): Ishii Y, Eto M, Mano Y, Tateda K, Yamaguchi K.
  • Journal Title: Antimicrob Agents Chemother Volume: 54 Pages: 3625-3629
  • Peer Reviewed
• [Journal Article] Rapidly spreading CTX-M-type β-lactamase-producing Proteus mirabilis in Japan (2010)
  • Author(s): Kanayama A, Iyoda T, Matsuzaki K, Saika T, Ikeda F, Ishii Y, Yamaguchi K, Kobayashi I
  • Journal Title: Int J Antimicrob Agents Volume: 36 Pages: 340-342
  • Peer Reviewed
• [Journal Article] Efficacy of calcium-EDTA as an inhibitor for metallo-β-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia (2010)
  • Author(s): Aoki N, Ishii Y, Tateda K, Saga T, Kimura S, Kikuchi Y, Kobayashi T, Tanabe Y, Tsukada H, Gejyo F, Yamaguchi K
  • Journal Title: Antimicrob Agents Chemother Volume: 54 Pages: 4582-4588
  • Peer Reviewed
• [Journal Article] 新規カルバペネム系薬耐性因子、ニュー・デリー型メタロβラクタマーゼ(NDM-1)の特徴 (2010)
  • Author(s): 石井良和
  • Journal Title: 日本化学療法学会雑誌 Volume: 58 Pages: 639-643
  • NAID: 10027469123
  • Peer Reviewed
• [Presentation] Trends in Antimicrobial Susceptibility among Bacterial Isolates from Urinary Tract Infections in Japanese Hospitals Participating in the Levofloxacin Surveillance Group during the Period 1994-2010 (2012)
  • Author(s): Ishii Y, Ohno A, Tateda K, Kashitani F, Yamaguchi K and the Levofloxacin Surveillance Group
  • Organizer: 15th International Congress on Infectious Diseases
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2012-06-16
• [Presentation] 多剤耐性菌への挑戦-ESBL産生菌の変遷と最新知見- (2012)
  • Author(s): 石井良和
  • Organizer: 第60回日本化学療法学会学術集会・第86回日本感染症学会総会学術講演会(Jointシンポジウム)
  • Place of Presentation: 長崎
  • Year and Date: 2012-04-26
• [Presentation] 多剤耐性菌感染症の現状と対策-多剤耐性グラム陰性菌- (2011)
  • Author(s): 石井良和
  • Organizer: 第43回日本小児感染症学会総会学術集会(シンポジウム)
  • Place of Presentation: 岡山
  • Year and Date: 2011-10-29
• [Presentation] 多剤耐性菌感染症の現状と対策-多剤耐性グラム陰性菌- (2011)
  • Author(s): 石井良和
  • Organizer: 第43回日本小児感染症学会総会・学術集会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)(招待講演)
  • Year and Date: 2011-10-29
• [Presentation] 薬剤耐性菌をめぐる諸問題-多剤耐性菌の現状と耐性メカニズム- (2011)
  • Author(s): 石井良和
  • Organizer: 第60回日本感染症学会東日本地方会学術集会・第58回日本化学療法学会東日本支部総会合同学会(シンポジウム)
  • Place of Presentation: 山形
  • Year and Date: 2011-10-27
• [Presentation] 薬剤耐性菌をめぐる諸問題-多剤耐性菌の現状と耐性メカニズム- (2011)
  • Author(s): 石井良和
  • Organizer: 第60回日本感染症学会東日本地方会学術集会第58回日本化学療法学会東日本支部総会合同学会
  • Place of Presentation: ホテルメトロポリタン山形・山形テルサ(山形県)(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Characterization of ESBL (Extended-spectrum β-lactamase) producing Escherichia colifrom patients, students as a healthy human, raw chicken meats and healthy chicken stools (2011)
  • Author(s): Ishii Y, Yoshizumi A, Saga T, Harada S, Kuroda M, Igimi S, Yamaguchi K and Tateda K
  • Organizer: 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: Chicago, USA.
  • Year and Date: 2011-09-20
• [Presentation] National spread of Pseudomonas aeruginosa ST235 and ST357 producing metallo-β-lactamases in Japan (2011)
  • Author(s): Ishii Y, Mano Y, Saga T, Harada S, Yamaguchi K and Tateda K
  • Organizer: 51st Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: Chicago, USA.
  • Year and Date: 2011-09-17
• [Presentation] MICを再考する-1. 基礎的立場から最小発育阻止濃度とブレイクポイントの意味を考察する- (2011)
  • Author(s): 石井良和
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2011-06-24
• [Presentation] β-barrel machinery assembly (BAM) complexを標的とした合成ペプチドによる緑膿菌感染症に対する新規治療法の基礎的検討 (2011)
  • Author(s): 森伸晃, 石井良和, 舘田一博, 良原栄策, 木村聡一郎, 光永滋樹, 猪子英俊, 山口惠三
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌コンベンションホール(北海道)
  • Year and Date: 2011-06-24
• [Presentation] 新規コリスチン徐放化製剤のエンドトキシン敗血症マウスモデルにおける治療効果 (2011)
  • Author(s): 南條友央太, 石井良和, 木村聡一郎, 舘田一博, 山口惠三
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌コンベンションホール(北海道)
  • Year and Date: 2011-06-24
• [Presentation] NDM-1産生K.pneumoniaeおよびE.coliに対するCa-EDTA併用効果の検討 (2011)
  • Author(s): 吉住あゆみ, 石井良和, 舘田一博, 木村聡一郎, 原田壮平, 嵯峨知生, 山口惠三
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌コンベンションホール(北海道)
  • Year and Date: 2011-06-24
• [Presentation] MICを再考する1.基礎的立場から最小発育阻止濃度とブレイクポイントの意味を考察する (2011)
  • Author(s): 石井良和
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌コンベンションホール(北海道)(招待講演)
  • Year and Date: 2011-06-24
• [Presentation] マクロライド剤の緑膿菌Quorum sensingとcyclic di-GMPシグナル伝達機構への作用機序 (2011)
  • Author(s): 木村聡一郎, 森伸晃, 舘田一博, 石井良和, 山口惠三
  • Organizer: 第59回日本化学療法学会総会
  • Place of Presentation: 札幌コンベンションホール(北海道)
  • Year and Date: 2011-06-23
• [Presentation] Trends in antimicrobial susceptibility among bacterial isolates from UTI of Japanese hospitals participating in the Levofloxacin Surveillance Group during 1994-2010 (2011)
  • Author(s): Ishii Y, Ohno A, Tateda Kand Yamaguchi K
  • Organizer: 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) & 27th International Congress of Chemotherapy (ICC)
  • Place of Presentation: Milan, Italy
  • Year and Date: 2011-05-10
• [Presentation] Characterisation of extended-spectrum β-lactamase- producing Escherichia colifrom clinical patients, chicken meat and domestic animals (2011)
  • Author(s): Ishii Y, Eto M, Esaki H, Saga T, Harada S, Yoshizumi A, Tateda K, Kuroda M, Igimi S, Rambach A and Yamaguchi K
  • Organizer: 21st European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) & 27th International Congress of Chemotherapy (ICC)
  • Place of Presentation: Milan, Italy
  • Year and Date: 2011-05-08
• [Presentation] 耐性菌の基礎から疫学までー細菌の抗菌薬耐性獲得の妙技ー (2011)
  • Author(s): 石井良和
  • Organizer: 第26回日本環境感染学会総会(シンポジウム)
  • Place of Presentation: 横浜
  • Year and Date: 2011-02-19
• [Presentation] 耐性菌の基礎から疫学まで:細菌の抗菌薬耐性獲得の妙技 (2011)
  • Author(s): 石井良和
  • Organizer: 第26回日本環境感染学会総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-02-19
• [Presentation] 薬剤耐性菌の現状と課題:ヒトにおける現状と課題 (2011)
  • Author(s): 石井良和
  • Organizer: 平成22年度日本獣医師会 獣医学術学会年次大会
  • Place of Presentation: 岐阜都ホテル(岐阜県)
  • Year and Date: 2011-02-13
• [Presentation] 国際委員会報告:韓国臨床微生物学会報告、CLSIミーティング報告 (2011)
  • Author(s): 石井良和
  • Organizer: 第22回日本臨床微生物学会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
  • Year and Date: 2011-01-09
• [Presentation] Novel immunochromatographical detection system for OXA-type carbepenemases (2010)
  • Author(s): Ishii Y, Kouyama Y, Fuke A, Tateda K, Harada S, Shibahara Y, Uesaka Y and Yamaguchi K
  • Organizer: 12th Western Pacific Congress on Chemotherapy and Infectious Diseases
  • Place of Presentation: Singapole,Singapole
  • Year and Date: 2010-12-03
• [Presentation] 「ESBLを基礎と臨床からしっかり学ぶ」1. ESBLとは-薬剤耐性のメカニズム- (2010)
  • Author(s): 石井良和
  • Organizer: 第59回日本感染症学会東日本地方会総会・第57回日本化学療法学会東日本支部総会(シンポジウム)
  • Place of Presentation: 東京
  • Year and Date: 2010-10-22
• [Presentation] 多角的視点から見た医療関連感染症対策-予防、治療、地域連携、環境要因対策など総合的ストラテジーの重要性一環境要因対策の視点から「環境要因がもたらす薬剤耐性菌伝播拡大のポテンシャル」 (2010)
  • Author(s): 石井良和
  • Organizer: 第59回日本感染症学会東日本地方会学術集会、第57回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-10-22
• [Presentation] ESBLを基礎と臨床からしっかり学ぶ (2010)
  • Author(s): 石井良和
  • Organizer: 第59回日本感染症学会東日本地方会学術集会、第57回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-10-22
• [Presentation] 臨床分離株の感受性調査-2009年度メロペン全国サーベイランスの結果報告 (2010)
  • Author(s): 石井良和, 山口恵三
  • Organizer: 第59回日本感染症学会東日本地方会学術集会、第57回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-10-21
• [Presentation] 健常人におけるESBL(基質特異性拡張型β-ラクタマーゼ)産生菌の検出状況 (2010)
  • Author(s): 眞野容子, 古谷信彦, 石井良和, 山口恵三
  • Organizer: 第59回日本感染症学会東日本地方会学術集会、第57回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-10-21
• [Presentation] 「耐性菌を生まない、耐性菌に負けない抗菌化学療法」我が国における抗菌薬耐性菌の現状 (2010)
  • Author(s): 石井良和
  • Organizer: 日本病院薬剤師会関東ブロック第40回学術大会
  • Place of Presentation: 東京ファッションタウンビルTFTホール(東京都)
  • Year and Date: 2010-08-29
• [Presentation] Is the prevalence of carbapenemase-producing Gram-negative bacilli in Japan increasing? (International Symposium) (2010)
  • Author(s): Ishii Y
  • Organizer: 13th Annual Meeting of Korean Sociery of Clinical Microbiology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-07-08
• [Presentation] Is the Prevalence of Carbapenemase-producing Gram-negative Bacilli in Japan Increasing? (2010)
  • Author(s): Ishii Y
  • Organizer: 13th Annual Meeting of Korean Society of Clinical Microbiology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-07-08
• [Presentation] 薬剤耐性菌に関する最近の話題 (2010)
  • Author(s): 石井良和
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎ブリックホール(長崎県)
  • Year and Date: 2010-06-04
• [Presentation] プラバスタチンはCandida albicansのファルネソール産生を抑制し、播種性カンジダ症モデルマウスの生存率を改善する (2010)
  • Author(s): 田代将人, 舘田一博, 木村聡一郎, 大野章, 石井良和, 河野茂, 山口恵三
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎ブリックホール(長崎県)
  • Year and Date: 2010-06-04
• [Presentation] 腸内細菌に対するキノロン剤の有効性の検討 ナリジクス酸耐性株の頻度と殺菌抵抗性の視点から (2010)
  • Author(s): 青池望, 安井久美子, 村上日奈子, 岩田守弘, 吉沢定子, 宮崎泰斗, 石井良和, 舘田一博, 山口恵三
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎ブリックホール(長崎県)
  • Year and Date: 2010-06-03
• [Presentation] マウスモデルにおけるレジオネラ・ニューモフィラ肺炎の診断マーカーの量的・動力学的再評価 (2010)
  • Author(s): 陳愉, 舘田一博, 藤田和恵, 木村聡一郎, 石井良和, 山口恵三
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎新聞文化ホール(長崎県)
  • Year and Date: 2010-06-03
• [Presentation] レジオネラ肺感染モデルにおけるL.pneumophilaとL.longbeachae肺炎の病態に関する検討 (2010)
  • Author(s): 藤田和恵, 舘田一博, 木村聡一郎, 石井良和, 山口恵三
  • Organizer: 第58回日本化学療法学会総会
  • Place of Presentation: 長崎新聞文化ホール(長崎県)
  • Year and Date: 2010-06-03
• [Presentation] Novel Imunochromatographical Detection System for OXA-type Carbapenemases (2010)
  • Author(s): Ishii Y, Kouyama Y, Fuke A, Tateda K, Harada S, Shibahara Y, Uesaka Y, Yamaguchi K
  • Organizer: 12th Western Pacific Congress on Chemotherapy and Infectious Diseases
  • Place of Presentation: Shangri-la Hotel, (Singapore)
  • Year and Date: 2010-06-03
• [Presentation] 耐性菌をめぐる諸課題 ～医療のみの問題か～医療領域における抗菌薬耐性菌 (2010)
  • Author(s): 石井良和
  • Organizer: 第84回日本感染症学会総会(パネルディスカッション)
  • Place of Presentation: 京都
  • Year and Date: 2010-04-06
• [Presentation] 耐性菌をめぐる諸課題-医療のみの問題か- (2010)
  • Author(s): 石井良和
  • Organizer: 第84回日本感染症学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-04-06
• [Presentation] 緑膿菌cyclic di-GMPを介した病原性制御機構に及ぼすマクロライド剤の効果 (2010)
  • Author(s): 木村聡一郎, 舘田一博, 石井良和, 山口恵三
  • Organizer: 第84回日本感染症学会総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2010-04-06
• [Presentation] 薬物耐性の分子メカニズム －細菌のセファロスポリン耐性機構－
  • Author(s): 石井良和
  • Organizer: 第155回日本獣医学会比較薬理学毒性学分科会
  • Place of Presentation: 東京大学駒場キャンパス（東京都）
  • Invited
• [Presentation] 始まった市中型感染症原因菌の逆襲 ESBL産生大腸菌の逆襲
  • Author(s): 石井良和
  • Organizer: 第86回日本細菌学会総会
  • Place of Presentation: 幕張メッセ（千葉県）
  • Invited
• [Presentation] カルバペネム薬耐性グラム陰性菌の疫学と基礎的見地からの感染対策への考察
  • Author(s): 石井良和
  • Organizer: 第28回日本環境感染学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Invited
• [Presentation] 多剤耐性菌の検出法（判定基準を含めて） OXA-型カルバペネマーゼ産生アシネトバクター属菌の検出法
  • Author(s): 石井良和
  • Organizer: 第24回日本臨床微生物学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県）
  • Invited
• [Presentation] βラクタマーゼ学：構造・活性からその特徴を科学する βラクタマーゼ：何が分かって何が分からないのか
  • Author(s): 石井良和
  • Organizer: 第61回日本感染症学会東日本地方会学術集会 第59回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: ホテル日航東京（東京都）
  • Invited
• [Presentation] 多剤耐性菌に対する併用療法を再考する 基礎的立場からの併用薬の再考
  • Author(s): 石井良和
  • Organizer: 第61回日本感染症学会東日本地方会学術集会 第59回日本化学療法学会東日本支部総会 合同学会
  • Place of Presentation: ホテル日航東京（東京都）
  • Invited
• [Presentation] 故井上松久理事長メモリアルセッション βラクタマーゼ：その疫学から機能・発現制御まで
  • Author(s): 石井良和
  • Organizer: 第60回日本化学療法学会学術集会
  • Place of Presentation: 長崎ブリックホール（長崎県）
  • Invited
• [Presentation] カルバペネム耐性菌の今後
  • Author(s): 石井良和
  • Organizer: 第60回日本化学療法学会学術集会
  • Place of Presentation: 長崎ブリックホール（長崎県）
  • Invited
• [Presentation] Jointシンポジウム3 耐性菌への挑戦 ESBL産生菌の変遷と最新知見
  • Author(s): 石井良和
  • Organizer: 第86回日本感染症学会総会・学術講演会、第60回日本化学療法学会学術集会
  • Place of Presentation: 長崎ブリックホール（長崎県）
  • Invited
• [Presentation] Trends in Antimicrobial Susceptibility among Bacterial Isolates from Urinary Tract Infections in Japanese Hospitals Participating in the Levofloxacin Surveillance Group during the Period 1994-2010
  • Author(s): Ishii Y
  • Organizer: 15th International Congress on Infectious Diseases
  • Place of Presentation: Bangkok, Thailand
• [Presentation] DS-8587, A New Generation of Broad Spectrum Quinolone: In vitro Antibacterial Activity Against Japanese Clinical Isolates of ESBL producing Escherichia coli
  • Author(s): Ishii Y
  • Organizer: 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy
  • Place of Presentation: San Francisco, U.S.A.
• [Book] 感染症事典(感染症事典編集委員会編) (2012)
  • Author(s): 石井良和
  • Publisher: オーム社
• [Book] ガイドラインサポートハンドブック 呼吸器感染症(河野茂編) (2011)
  • Author(s): 石井良和
  • Publisher: 医薬ジャーナル社
• [Book] 小児耐性菌感染症の治療戦略(砂川慶介編) (2011)
  • Author(s): 石井良和
  • Publisher: 医薬ジャーナル社
• [Book] 感染症専門医テキスト第一部解説編(社団法人日本感染症学会編) (2011)
  • Author(s): 石井良和
  • Publisher: 南江堂
• [Book] 感染症診療の基礎と臨床～耐性菌の制御に向けて～(一山智、山口惠三監修) (2010)
  • Author(s): 石井良和
  • Publisher: 医薬ジャーナル社
• [Book] 薬剤師国家試験対策参考書7. 病態・薬物治療(薬学ゼミナール編) (2010)
  • Author(s): 石井良和
  • Publisher: 薬学ゼミナール
• [Book] 薬剤師国家試験対策参考書5. 薬理(薬学ゼミナール編) (2010)
  • Author(s): 石井良和
  • Publisher: 薬学ゼミナール
• [Remarks]
  • URL: http://www.lab.toho-u.ac.jp/med/micro/
• [Patent(Industrial Property Rights)] オキサ型β-ラクタマーゼ産生菌の検出方法、同定方法およびキット (2012)
  • Inventor(s): 山口惠三、石井良和、舘田一博、神山裕一、上原良彦、柴原裕亮
  • Industrial Property Rights Holder: 山口惠三、石井良和、舘田一博
  • Acquisition Date: 2012-11-02