Application of anti-crytpococcal cell surface protein antibody against latent infection diagnosis and control of severe diseases of cryptococcosis
| Project/Area Number |
22591115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
OHNO Hideaki 国立感染症研究所, 生物活性物質部, 室長 (20325640)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGOE Satoshi 国立感染症研究所, 生物活性物質部, 主任研究官 (00212283)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 日和見感染症 / 感染症 / クリプトコックス症 / Cryptococcus neoformans / 潜伏感染 |
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| Research Abstract |
Cell surface and secretory proteins of Cryptococcus neoformans were detected using signal sequence trap (SST) method, and monoclonal antibodies against one of those proteins were obtained. In addition, the possibility of detection of latent infection diagnosis and controlling severe cryptococcal diseases applying with antibodies were also evaluated. Consequently, the protein was confirmed on cell wall and to be secreted outside cell under both aerobic and anaerobic conditions, and it speculated that it was a candidate protein on diagnosis of Cryptococcus latent infection, however, that protein seemed to have no relevance with cell growth.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] Determination of epidemiology of clinically isolated Cryptococcus neoformans strains in Japan by multilocus sequence typing.2013
Author(s)
Umeyama T, Ohno H, Minamoto F, Takagi T, Tanamachi C, Tanabe K, Kaneko Y, Yamagoe S, Kishi K, Fujii T, Takemura H, Watanabe H, Miyazaki Y
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Journal Title
Jpn J Infect Dis
Volume: 66
Pages: 51-55
NAID
Related Report
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[Journal Article] Multilocus sequence typing of Cryptococcus neoformans in non-HIV associated cryptococcosis in Nagasaki, Japan.2013
Author(s)
Mihara T, Izumikawa K, Kakeya H, Ngamskulrungroj P, Umeyama T, Takazono T, Tashiro M, Nakamura S, Imamura Y, Miyazaki T, Ohno H, Yamamoto Y, Yanagihara K, Miyazaki Y, Kohno S
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Journal Title
Med Mycol
Volume: 51 (3)
Pages: 252-260
Related Report
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[Journal Article] Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosynthetic genes in Candida glabrata2011
Author(s)
Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, Higashi S, Ueno K, Chibana H, Niimi M, Yamagoe S, Umeyama T, Kajiwara S, Ohno H, Miyazaki Y
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Journal Title
Genes Cells
Volume: 16
Pages: 80-89
Related Report
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[Journal Article] 髄膜炎、脳炎2011
Author(s)
大野秀明
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Journal Title
新版 感染症診療実践ガイド 有効な抗菌薬の使い方のすべて
Volume: Medical Practice臨時増刊号
Pages: 352-358
Related Report
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[Journal Article] Transcription factors CgUPC2A and CgUPC2B regulate ergosterol biosyntheticgenes in Candida glabrata.2011
Author(s)
Nagi M, Nakayama H, Tanabe K, Bard M, Aoyama T, Okano M, Higashi S, Ueno K, Chibana H, Niimi M, Yamagoe S, Umeyama T, Kajiwara S, Ohno H, Miyazaki Y
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Journal Title
Genes Cells
Volume: 16
Pages: 80-89
Related Report
Peer Reviewed
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