| Project/Area Number |
22591117
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Toyama Institute of Health |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ITAMOCI Masae (IWAI Masae) 富山県衛生研究所, ウイルス部, 主任研究員 (70393080)
NAGOYA Mayumi (OBARA Mayumi) 富山県衛生研究所, ウイルス部, ウイルス部 (80393081)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ノロウイルス / 疫学 / 感染性胃腸炎 / 遺伝子変異 |
|---|
| Research Abstract |
There are many genotypes in norovirus (NoV), and NoV causes outbreak repeatedly with high frequency of mutation. In this research, NoV genes detected from patients and sewer influents were compared to understand the molecular basis of the outbreak in an area. While genotype GI.4 was mainly detected from sewer influents for long period with less frequency of mutation, different recombinant variants or subtypes of GII.2, 3, or 4, respectively appeared rise and fall in outbreaks for every season. It was suggested that the genotypes causing an apparent interaction with a host show higher genetic variations.
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