Impact of epileptic seizures on developing brain: a study using forebrain-specific Cdk5 conditional knockout mice
Project/Area Number |
22591118
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Project Period (FY) |
2010-04-01 – 2013-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | てんかん / けいれん / 神経変性 / 炎症 / 皮質形成異常 / Cdk5 / 脳・神経 / モデル動物 / cyclin-dependent kinase 5 / 脳形成異常 / 神経細胞移動 / ノックアウトマウス / tissue-type plasminogen activator |
Research Abstract |
Neuronal migration disorders are often identified in patients with epilepsy refractory to medical treatment. The prolonged or repeated seizures are known to cause neuronal death; however, the mechanism remains to be elucidated. The objective of this study is to elucidate the impact of epileptic seizures on the developing brain using forebrain-specific Cdk5 knockout (Cdk5cKO) mice which show neuronal migration defects and seizures. The forebrain of the mice showed neurodegenerative changes accompanied by neuronal loss and microglial activation. Treatment with PPAR-gamma agonist pioglitazone ameliorated gliosis and neuronal loss in Cdk5cKO mice, suggesting that inflammation contributes to the pathogenesis of the seizure-induced neuronal death. This study may provide impetus for considering the development of anti-inflammatory therapies that can be used to avoid the progressive decline of neuronal function in patients with neuronal migration disorders and epilepsy.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Phosphorylation of P27Kipl at Thr187 by Cyclin-dependent Kinase 5 Modulates Neural Stem Cell Differentiation.2010
Author(s)
Zheng YL, Li BS, Rudrabhatla P, Shuk la V, Amin ND, Maric D, Kesavapany S, Kanungo 」, Pareek TK, Takahashi S, Grant P, Kulkarni AB, Pant HC
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Journal Title
Molecular Biology of the Cell
Volume: Vol.21
Pages: 3601-3614
Related Report
Peer Reviewed
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