| Project/Area Number |
22591123
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
AIHARA Masao 山梨大学, 大学院・医学工学総合研究部, 教授 (30242639)
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| Co-Investigator(Kenkyū-buntansha) |
KANEMURA Hideaki 山梨大学, 大学院・医学工学総合研究部, 助教 (40359724)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 認知神経科学 / 発達障害 / 前頭葉機能 / 社会脳 / 認知 / 情動 / 認知神経学 / 行動抑制 / 遺伝薬理学 / 遺伝子多型 / モラル |
|---|
| Research Abstract |
In current neuropsychological theory, the core symptoms in developmental disorders are considered to be caused by abnormal selection and maintenance of motor response to stimuli, due to a failure to inhibit or delay behavioral responses, which are also hypothesized to lead to secondary impairment in frontal lobe function (executive functions). We confirmed that evidences of disinhibition in developmental disorders came from neuropsychological tasks, such as memory-guided saccade task, continuous performance test, and Markov decision task using neurophysiological methods (saccade eye movement, NoGo potential, and sympathetic skin response). In addition, we confirmed that emotional autonomic response is a critical requirement for decision making of future outcomes.
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