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Cognitive neuroscience of frontal lobe function (social brain) in developmental disorders

Research Project

Project/Area Number 22591123
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionUniversity of Yamanashi

Principal Investigator

AIHARA Masao  山梨大学, 大学院・医学工学総合研究部, 教授 (30242639)

Co-Investigator(Kenkyū-buntansha) KANEMURA Hideaki  山梨大学, 大学院・医学工学総合研究部, 助教 (40359724)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords認知神経科学 / 発達障害 / 前頭葉機能 / 社会脳 / 認知 / 情動 / 認知神経学 / 行動抑制 / 遺伝薬理学 / 遺伝子多型 / モラル
Research Abstract

In current neuropsychological theory, the core symptoms in developmental disorders are considered to be caused by abnormal selection and maintenance of motor response to stimuli, due to a failure to inhibit or delay behavioral responses, which are also hypothesized to lead to secondary impairment in frontal lobe function (executive functions). We confirmed that evidences of disinhibition in developmental disorders came from neuropsychological tasks, such as memory-guided saccade task, continuous performance test, and Markov decision task using neurophysiological methods (saccade eye movement, NoGo potential, and sympathetic skin response). In addition, we confirmed that emotional autonomic response is a critical requirement for decision making of future outcomes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (47 results)

All 2013 2012 2011 2010 Other

All Journal Article (20 results) (of which Peer Reviewed: 15 results) Presentation (19 results) (of which Invited: 2 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Can EEG characteristics predict development of epilepsy in autistic children?.2013

    • Author(s)
      Kanemura H, Sano F, Tando T, Sugita K, Aihara M
    • Journal Title

      Eur J paediatr Neurol

      Volume: 17 Pages: 232-237

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Can EEG characteristics predict development of epilepsy in autistic children?2013

    • Author(s)
      Kanemura H
    • Journal Title

      Eur J Paediatr Neurol

      Volume: 17 Pages: 232-237

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Do sequential EEG changes predict atypical clinical features in rolandic epilepsy?2013

    • Author(s)
      Kanemura H
    • Journal Title

      Dev Med Child Neurol

      Volume: 54 Pages: 912-917

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated seizures induce prefrontal growth disturbance in frontal lobe epilepsy2012

    • Author(s)
      Kanemura H, Sano F, Tando T, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 34 Pages: 175-180

    • NAID

      10031049985

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Do sequential EEG changes predict atypical clinical features in rolandic epilepsy?2012

    • Author(s)
      Kanemura H, Sano F, Aoyagi K, Sugita K, Aihara M.
    • Journal Title

      Dev Med Child Neurol

      Volume: 54 Pages: 912-917

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neurobiological effects of CSWS on brain growth: A magnetic resonance imaging volumetric study2012

    • Author(s)
      Kanemura H, Aihara M
    • Journal Title

      J Pediatr Epilepsy

      Volume: 1 Pages: 187-193

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] てんかん児の前頭葉機能(社会脳)に関する神経機能解剖学的研究.2012

    • Author(s)
      相原正男
    • Journal Title

      てんかん治療研究振興財団研究年報

      Volume: 23 Pages: 67-72

    • Related Report
      2012 Final Research Report
  • [Journal Article] 認知神経科学よりみた発達障害の脱抑制2012

    • Author(s)
      相原正男
    • Journal Title

      認知神経科学

      Volume: 13 Pages: 233-240

    • NAID

      130006895738

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 認知神経科学よりみた発達障害の脱抑制.2012

    • Author(s)
      相原正男
    • Journal Title

      認知神経科学

      Volume: 13 Pages: 233-240

    • NAID

      130006895738

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated seizures induce prefrontal growth disturbances in frontal lobe epilepsy2012

    • Author(s)
      Kanemura H
    • Journal Title

      Brain Development

      Volume: 42 Pages: 175-180

    • NAID

      10031049985

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial changes of prefrontal lobe growth in the patients with benign childhood epilepsy with centrotemporal spikes presenting with cognitive impairments/behavioral problems2011

    • Author(s)
      Kanemura H, Hata S, Aoyagi K, Sugita K, Aihara M
    • Journal Title

      Brain Dev

      Volume: 33 Pages: 106-113

    • NAID

      10029560436

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ictal SPECT of thalamocortical coupling in a patient with frontal absence.2011

    • Author(s)
      Kanemura H, Sano F, Sugita K, Aihara M
    • Journal Title

      Neuropediatrics

      Volume: 42 Pages: 200-203

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 神経生理学的検査による早期発見・支援は可能か?特集 1・再考:発達障害児の早期発見・早期支援.2011

    • Author(s)
      後藤裕介、相原正男
    • Journal Title

      教育と医学

      Volume: 59 Pages: 14-22

    • Related Report
      2012 Final Research Report
  • [Journal Article] Ictal SPECT of thalamocortical coupling in a patient with frontal absence2011

    • Author(s)
      Kanemura H
    • Journal Title

      Neuropediatrics

      Volume: 42 Pages: 200-203

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 前頭前野の成長・発達と左右差.特集神経系の左右差-Broca 150年-2011

    • Author(s)
      相原正男
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 671-674

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Serial changes of prefrontal lobe growth in the children with centro-temporal spikes presenting with cognitive/behavioral problems2011

    • Author(s)
      Kanemura Hideaki
    • Journal Title

      Bxain Development

      Volume: 33 Pages: 106-113

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Saccade eye movements as a quantitative measure of frontostriatal network in children with ADHD2010

    • Author(s)
      Goto Y, Hatakeyama K, Kitama T, Sato Y, Kanemura H, Aoyagi K, Sugita K, Aihara M.
    • Journal Title

      Brain Dev

      Volume: 33 Pages: 347-355

    • NAID

      10027491228

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児科領域における ADHD 臨床の新展開. 特集 ADHD 臨床の新展開 II.2010

    • Author(s)
      相原正男
    • Journal Title

      精神科治療

      Volume: 25 Pages: 895-902

    • Related Report
      2012 Final Research Report
  • [Journal Article] Saccade eye movements as a quantitative measure of frontostriatal network inchildren with ADHD2010

    • Author(s)
      Goto Yusuke
    • Journal Title

      Brain Development

      Volume: 32 Pages: 347-355

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 小児科領域におけるADHDの新展開.特集ADHDの新展開II2010

    • Author(s)
      相原正男
    • Journal Title

      精神科治療学

      Volume: 25 Pages: 895-902

    • Related Report
      2010 Annual Research Report
  • [Presentation] 認知神経科学よりみた小児てんかん.2012

    • Author(s)
      相原正男
    • Organizer
      第1回北部九州てんかんミーティング
    • Place of Presentation
      福岡
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知神経科学よりみた発達障害2012

    • Author(s)
      相原正男
    • Organizer
      第4回東北発達障害研究会
    • Place of Presentation
      仙台
    • Year and Date
      2012-02-04
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会脳を育む2012

    • Author(s)
      相原正男. 基調講演
    • Organizer
      第39回日本てんかん協会全国大会
    • Place of Presentation
      山梨
    • Related Report
      2012 Final Research Report
  • [Presentation] Atypical BECT 患児における認知機能の経時的推移2012

    • Author(s)
      金村英秋、佐野史和、保坂裕美、溝呂木園子、反頭智子、青柳閣郎、杉田完爾、相原正男.
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] 社会脳を育む.2012

    • Author(s)
      相原正男
    • Organizer
      第39回日本てんかん協会全国大会.
    • Place of Presentation
      春日井ホテル(山梨県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 事象関連電位を利用した前頭葉機能検査2011

    • Author(s)
      相原正男
    • Organizer
      第41回日本臨床神経生理学会学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2011-11-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 治療抵抗性を示した BECT 患児における認知機能の経時的推移.2011

    • Author(s)
      金村英秋、溝呂木園子、青柳閣郎、保坂裕美、杉田完爾、相原正男.
    • Organizer
      第41回日本臨床神経生理学会 サテライトシンポジウム1
    • Place of Presentation
      静岡
    • Year and Date
      2011-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知神経科学よりみた発達障害の脱抑制-サッケード、Go/NoGo、強化学習課題を用いて-.2011

    • Author(s)
      相原正男
    • Organizer
      第16回認知神経科学会学術集会.
    • Place of Presentation
      北九州
    • Year and Date
      2011-10-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知神経科学よりみた発達障害の脱抑制-サッケード、Go/NoGo、強化学習課題を用いて-2011

    • Author(s)
      相原正男
    • Organizer
      第16回認知神経科学会学術集会
    • Place of Presentation
      ラマニテイーホール(北九州)(招待講演)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Can EEG characteristics predict later development of epilepsy in children with autism spectrum disorders?2011

    • Author(s)
      Kanemura H, Sano F, Tando T, Aihara M
    • Organizer
      Joint Academic Conference on Autism Spectrum Disorders
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Final Research Report
  • [Presentation] 治療抵抗性を示したBECT 患児におけるK-ABCの経時的推移.2011

    • Author(s)
      金村英秋、溝呂木園子、青柳閣郎、保坂裕美、反頭智子、杉田完爾、相原正男
    • Organizer
      第16回認知神経科学会.
    • Place of Presentation
      北九州
    • Related Report
      2012 Final Research Report
  • [Presentation] 自閉性障害患児におけるてんかん発症と脳波所見との関連2011

    • Author(s)
      金村英秋、佐野史和、反頭智子、畠山和男、相原正男.
    • Organizer
      第45回日本てんかん学会
    • Place of Presentation
      新潟
    • Related Report
      2012 Final Research Report
  • [Presentation] EEG characteristics predict subsequent epilepsy in children with febrile seizure.2011

    • Author(s)
      Kanemura H, Sano F, Yamashiro D, Sugita K, Aihara M.
    • Organizer
      29th International Epilepsy Congress
    • Place of Presentation
      Rome,Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] ランチョンセミナー:社会脳の発達とその障害-小児てんかんとの関わりを通して-.2010

    • Author(s)
      相原正男
    • Organizer
      第44回日本てんかん学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] てんかんと社会脳2010

    • Author(s)
      相原正男
    • Organizer
      日本てんかん学会
    • Place of Presentation
      岡山
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 臨床神経学的見地(前頭葉機能)からの示唆-病態を検討した上での地域療育への提言-、市民公開講座発達障害は、今、増えているのか-現状の把握と未来への提言-2010

    • Author(s)
      相原正男
    • Organizer
      第52回日本小児神経学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-05-22
    • Related Report
      2012 Final Research Report
  • [Presentation] Saccade eye movements as a quantitative measure of frontostriatal network in children with ADHD2010

    • Author(s)
      Goto Y, Yamashiro D , Aihara M .
    • Organizer
      第87回日本生理学会大会 シンポジウム:Physiological approach to visualization of development of the mind and brain
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 前頭葉てんかん児における発作持続期間と前頭前野体積との関連-3-D MRI による前方視的検討-.2010

    • Author(s)
      金村英秋、畑 園子、畠山和男、杉田完爾、相原正男.
    • Organizer
      第52回日本小児神経学会総会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 子どもの神経発達

    • Author(s)
      相原正男
    • Organizer
      厚生労働省 平成24年度こころの健康づくり対策事業
    • Place of Presentation
      野村カンファランスプラザ日本橋(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Epilepsy in Childen - Clinical and Social Aspects2011

    • Author(s)
      Kanemura H, Aihara M.
    • Publisher
      Sequential prefrontal lobe volume changes in epileptic patients with continuous spikes and waves during slow sleep. In: Gadze ZP (Ed)
    • Related Report
      2012 Final Research Report
  • [Book] Epilepsy in Childen-Clinical and Social Aspects-, Croatia : INTECH(In : Gadze ZP (Ed))2011

    • Author(s)
      Kanemura H
    • Publisher
      Sequential prefrontal lobe volume changes in epileptic patients with continuous spikes and waves during slow sleep
    • Related Report
      2011 Annual Research Report
  • [Book] 認知機能の発達.2010

    • Author(s)
      相原正男
    • Publisher
      神経生理学からみた小児の情動/認知機能の発達.
    • Related Report
      2012 Final Research Report
  • [Book] 神経生理学からみた小児の情動ノ認知発達(小児科臨床ピクルス19巻)2010

    • Author(s)
      相原正男
    • Publisher
      中山書店
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.yamanashi.ac.jp/clinical/pediatr/top.htm

    • Related Report
      2012 Final Research Report
  • [Remarks] 山梨大学医学部小児科学講座

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/0/08E9C077A5EBA0FC.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.yamanashi.ac.jp

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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