Pathogenetic basis of seizure susceptibility in a hamster model of cortical malformation
| Project/Area Number |
22591125
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Shiga University of Medical Science |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 皮質形成異常 / 多小脳回症 / てんかん / けいれん準備性 / 介在神経細胞 / てんかん原性 / 介在ニューロン / parvalbumin / Ca結合蛋白 / 傍多小脳回領域 / 大脳皮質奇形 / 抑制性神経細胞 |
|---|
| Research Abstract |
Sustained elevation of the intracellular level of Ca2+ in response to glutamate receptor activation can result in depolymerization of microfilaments and microtubules, thus leading to dendritic outgrowth cessation and regression. These processes are suggested to be the primary mechanisms underlying the neuronal migration disorders and the resultant polymicrogyria observed in this experiment. A neuronal tracing study of progenitor cells in the ganglionic eminence using biotinylated dextran amine (BDA) demonstrated the interneurons to be mobilized to the microgyric area out of the ganglionic eminence, thus suggesting the development of new inhibitory neuronal connections after the onset of excitotoxic brain lesions. The lateral paramicrogyral area had the greatest number of parvalbumin-immunoreactive neurons, which was increased significantly in comparison to that in the control cortex (P < 0.01). We suggest that the callosal, thalamic and intracortical afferents to the microgyrus and paramicrogyral area may induce a remarkable imbalance between the excitatory and inhibitory activities of the cortical structures, associated with the epileptogenic mechanism in polymicrogyria.
|
Report
(4 results)
Research Products
(36 results)
-
-
-
-
-
[Journal Article] Compound heterozygote of a novel missense mutation (p.K402T) and a double missense mutation (p.[G71R;Y486D]) in type II Crigler-Najjar syndrome2011
Author(s)
Maruo Y, Ozgenc F, Mimura Y, Ota Y, Matsui K, Takahashi H, Mori A, Taga T, Takano T, Sato H, Takeuchi Y
-
Journal Title
J Pediatr Gastroenterol Nutr
Volume: 52
Issue: 3
Pages: 362-365
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Epstain-Barr virus-related lymphoproliferative disorder, cytomegalovirus reactivation, and varicella zoster virus encephalitis during treatment of medulloblastoma2011
Author(s)
Ohta M, Taga T, Nomura A, Kato H, Takano T, Maruo Y, Takeuchi Y, Ishida M, Ohta S
-
Journal Title
J Med Virol
Volume: 83
Issue: 9
Pages: 1582-1584
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
