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Activation of ER stress as the major molecular pathology in autism spectrum disorder and the animal model for intervention study

Research Project

Project/Area Number 22591135
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionJichi Medical University

Principal Investigator

MOMOI Mariko  自治医科大学, 医学部, 教授 (90166348)

Co-Investigator(Kenkyū-buntansha) MORI Masato  自治医科大学, 医学部, 講師 (10337347)
SAITO Mari  自治医科大学, 医学部, 研究員 (10424011)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords内科系臨床医学 / 小児科学 / 自閉性障害 / CADM1 / 自閉性障害関連遺伝子 / ERストレス
Research Abstract

We reported that the loss of Cadm1, one of the autism-related gene, caused decreased social ability, anxiety and aggression. The cells expressed mutated CADM1 protein showed the aberrant and aborted extension of neuronal spikes and the decreased synaptogenesis. We also detected that the mutated CADM1 expressing cells showed the activation of CHOP and beclin, that suggest the activation of ER stress in the cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (1 results)

  • [Journal Article] Cadm1-expressing synapses on Purkinje cell dendrites are involved in mouse ultrasonic vocalization activity.2012

    • Author(s)
      Fujita E et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 1 Pages: e30151-e30151

    • DOI

      10.1371/journal.pone.0030151

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autism spectrum disorder ; shared molecular pathology2011

    • Author(s)
      Momoi MY
    • Journal Title

      Medical Science Digest

      Volume: 37 Pages: 410-413

    • Related Report
      2011 Final Research Report
  • [Journal Article] Impairment of social and emotional behaviors in Cadm1-knockout mice2010

    • Author(s)
      Takayanagi Y, et al.
    • Journal Title

      Biochem. Biophys Res commun

      Volume: 396 Issue: 3 Pages: 703-708

    • DOI

      10.1016/j.bbrc.2010.04.165

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM12010

    • Author(s)
      Fujita E, et al.
    • Journal Title

      Cell Death and Disease

    • Related Report
      2011 Final Research Report
  • [Journal Article] Impairment of social and emotional behaviors in Cadm1-knockout mice2010

    • Author(s)
      Takayanagi Y, Fujita E, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 396 Pages: 703-708

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autism spectrum disorder is related to endoplasmic reticulum stress induced by mutations in the synaptic cell adhesion molecule, CADM12010

    • Author(s)
      Fujita E, Tanabe Y, et al
    • Journal Title

      Cell Death and Disease

      Volume: 1

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小児期の広汎性発達障害:遺伝子と環境

    • Author(s)
      桃井真里子
    • Organizer
      第28回日本医学会総会
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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