| Project/Area Number |
22591136
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
ARISAKA Osamu 獨協医科大学, 医学部, 教授 (60151172)
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| Co-Investigator(Renkei-kenkyūsha) |
SAIRENCHI Toshimi 獨協医科大学, 医学部, 准教授 (70453404)
SHIMURA Naoto 獨協医科大学, 医学部, 講師 (70211290)
KOYAMA Satomi 獨協医科大学, 医学部, 講師 (70364643)
YAMAZAKI Yuzuru 獨協医科大学, 医学部, 助教 (90566647)
ICHIKAWA Go 獨協医科大学, 医学部, 助教 (80438712)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児肥満 / 乳児肥満 / メタボリックシンドローム / body mass index / adiposity rebound / インスリン抵抗性 / 動脈硬化 / LDL粒子径 / small dense LDL / 母乳栄養 / 2型糖尿病 |
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| Research Abstract |
We examined the relationship between body mass index (BMI) during the period of adiposity rebound (AR), in which BMI increases in babyhood and begins to increase again after temporal decrease in childhood and at the age of 12 years, and the risk factors of arterial sclerosis, i.e., serum lipid level and blood pressure, in a birth cohort. As a result, it was demonstrated that: 1) abnormal findings, i.e., high BMI at 12 years of age, dyslipidemia, and high blood pressure tended to be observed in children with early AR, especially those aged 4 years or younger, 2) since no correlation was confirmed between the increase in body weight in babyhood and the period of AR, baby obesity doesnot cause future obesity, 3) the incidence of obesity at 12 years of age was lower in children with maternal feeding than in those with artificial feeding, 4) the living environment and habit, which may affect early AR are characteristic. It was revealed that future obesity and metabolic syndrome could be prevented by early intervention of the living habit inchildhood with a focus on the period of AR.
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