The mechanism of liver cancer onset in Wilson disease and its prevention
| Project/Area Number |
22591137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUZISAWA Chie 帝京大学, 医学部, リサーチフェロー (10393000)
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| Research Collaborator |
HIROKI Tomoko 帝京大学, 医学部, 研究員
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Wilson 病 / 銅 / LEC ラット / 酸化的ストレス / 肝癌 / 予防 / Wilson病 / 肝障害 / 酸化ストレスプロファイル / 肝臓 / LECラット |
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| Research Abstract |
Wilson disease (WD) causes various disorders by copper accumulationin the liver. The purpose of this study is to elucidate the onset mechanism of the liver damage including carcinogenesis in WD, and get the knowledge about its prevention. Using the model rat, it was revealed that copper accumulated and a mitochondrial disorder was induced in the liver from an early stage after birth, in addition, oxidative stress could not been controlled normally. Furthermore, the results of oxidative stress profile (OSP) analysis of the WD patient bodies suggested that a serum level of the certain fat-solubleantioxidants were decreasing, and about half of the patients are in the low active zone which means to have low antioxidant ability. These results suggested that the treatment with these antioxidants might prevent the progress of hepatic disorders including carcinogenesis in WD.
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Report
(4 results)
Research Products
(12 results)
