| Project/Area Number |
22591140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
AMEMIYA Shin 埼玉医科大学, 医学部, 教授 (10118903)
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| Co-Investigator(Renkei-kenkyūsha) |
OGATA Tsutomu 国立成育医療センター研究所, 小児思春期発育研究部, 部長 (40169173)
TOKUNAGA Katsiushi 東京大学, 大学院・医学系研究科・国際保健学専攻人類遺伝学分野, 教授 (40163977)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 小児 1 型糖尿病 / 遺伝素因 / HLA 遺伝子 / 自己免疫 / SNP / 疾患感受性遺伝子 / 疾患抵抗性遺伝子 / 遺伝子-遺伝子相互作用 / 小児1型糖尿病 / HLA / 遺伝子ー遺伝子相互作用 / HLAクラスII遺伝子 / HLAクラスI遺伝子 / ジェノミックインプリンティング / 連鎖不平衡 / 発症年齢 / HLA以外の遺伝子SNP / HLA遺伝子 / 疾患感受性アリル / DRB1-DQB1ハプロタイプ / DPB1 / 疾患抵抗性アリル |
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| Research Abstract |
Most cases of type 1 diabetes mellitus are type 1A (T1A), caused by an autoimmune reaction, involving genetic and environmental factors, which ultimately disrupt insulin-producing pancreatic β cells.This study analyzed the HLA-DRB1, DQB1, DPB1, A, C, and B genes in Japanese patients with T1A to identify candidate genes specific for Japanese individuals. Some of the genes were also involved in diabetes in Caucasian. The results of TDT demonstrated no genomic imprinting of HLA genes in Japanese patients. We also identified SNPs in genes other than HLA.
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