| Project/Area Number |
22591143
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIBASHI Masatoshi 久留米大学, 医学部, 教授 (20168256)
OKAMURA Hisayoshi 久留米大学, 高次脳疾患研究所, 助教 (00454918)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 思春期やせ症 / 近赤外線光トポグラフィー / 脳科学 / 摂食障害 / 神経性無食欲症 / SPECT / iomazenil SPECT |
|---|
| Research Abstract |
Anorexia nervosa (AN), which commonly occurs during adolescence in girls, is a disturbance of eating habits that is characterized by excessive preoccupation with body weight, shape, and food intake. The advanced neuroimaging studies showed that children with AN have remarkable concern with “attachment” which infants have experienced during their early childhood. It showed also significant decreased inhibitory neurogenic function in the cingulate cortex which control emotion, according to higher anxious and depressive symptoms. The abnormal neurogenic function returned to normal after bodyweight gained. Furthermore, eye-tracking examination revealed the evidence of preoccupation to food selectivity and shyness, which were difficult to be evaluated by patients. This study might contribute to patients and their parents for understanding well regarding AN
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