Development of molecular targeted therapy of bone marrow fibrosis with BACH1 transgenic mice

• Project/Area Number: 22591149
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Hirosaki University
• Principal Investigator: SASAKI Shinya 弘前大学, 医学部附属病院, 助教 (10344590)
• Co-Investigator(Kenkyū-buntansha): TERUI Kiminori 弘前大学, 医学部附属病院, 講師 (00333740) ; ITO Etsuro 弘前大学, 医学(系)研究科(研究院), 教授 (20168339)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 児血液学 / 骨髄線維症 / BACH1 / 転写因子 / トランスジェニックマウス / 血小板減少 / DNAマイクロアレイ / 分子標的療法 / HGF

Research Abstract

We performed this study using BACH1 transgenic mice (model mice for myelofibrosis) to understand the mechanism of myelofibrosis and develop the molecular target therapy, and found the following results
We identified the thromboxane A synthase gene as a BACH1 target in megakaryocytes.
We investigated the anti-myelofibrosis effects of hepatocyte growth factor, which has a function of suppressing fibrosis of various tissues, on BACH1 transgenic mice. However, no significant effects were observed.

Research Products

• [Journal Article] Hypercalcemia following umbilical cord blood transplantation to correct osteopetrosis associated with the NEMO mutation (2013)
  • Author(s): Sasaki S, Kamio T, Kudo K, Sato T, Tono C, Takahashi T , Terui K, Ito E
  • Journal Title: Hirosaki Med. J Volume: 64
  • NAID: 110009623619
  • URL: http://hdl.handle.net/10129/4872
• [Journal Article] Frequent somatic mosaicism of NEMO in T cells of patients with X-linked anhidrotic ectodermal dysplasia with immune- deficiency (2012)
  • Author(s): Kawai T, Imai C et al
  • Journal Title: Blood Volume: 119 Issue: 23 Pages: 5458-66
  • DOI: 10.1182/blood-2011-05-354167
  • Peer Reviewed
• [Journal Article] CD7-positive acute myelomonocytic leukemia with trisomy 21 as a sole acquired chromosomal abnormality in two adolescents (2011)
  • Author(s): Kudo K, Terui K, Sasaki S, MD, Kamio T, Sato T, Ito E
  • Journal Title: Leuk Res Volume: 35(9) Issue: 9 Pages: e167-e168
  • DOI: 10.1016/j.leukres.2011.04.016
  • Peer Reviewed
• [Journal Article] Voriconazole for both successful treatment of disseminated Trichosporon asahii infection and subsequent cord blood transplantation in an infant with acute myelogenous leukemia (2011)
  • Author(s): Kudo K, Terui K, MD, Sasaki S, Kamio T, Sato T, and Ito E
  • Journal Title: Bone Marrow Transplant Volume: 46(2) Issue: 2 Pages: 310-1
  • DOI: 10.1038/bmt.2010.96
  • Peer Reviewed
• [Journal Article] Guillain-Barre Syndrome minicking acute methotrexate-associated encephalopathy in an adolescent patient with lymphoblastic lymphoma (2010)
  • Author(s): Terui K, Takahashi Y, Sasaki S, Kudo K, Kamio T, Ito E
  • Journal Title: J Pediatr Hematol Oncol Volume: 32(8) Issue: 8 Pages: 615-6
  • DOI: 10.1097/mph.0b013e3181d204b1
  • Peer Reviewed
• [Journal Article] Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia. (2009)
  • Author(s): Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa DKawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K
  • Journal Title: Br J Haematol Volume: 141 Issue: 4 Pages: 567-575
  • DOI: 10.1111/j.1365-2141.2009.07968.x
  • Peer Reviewed
• [Presentation] 腎明細胞肉腫治療後、早期に治療関連骨髄性腫瘍を発症した一例 (2012)
  • Author(s): 佐藤知彦、中村多一郎、佐々木伸也、照井君典、伊藤悦朗
  • Organizer: 第54回日本小児血液・がん学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-11-30
• [Presentation] 自己免疫性溶血性貧血発症後に診断された慢性肉芽腫症の1例 (2012)
  • Author(s): 佐々木伸也、廣瀬千穂、中村多一郎、佐藤知彦、神尾卓哉、照井君典、伊藤悦朗
  • Organizer: 第64回北日本小児科学会
  • Place of Presentation: 新潟
  • Year and Date: 2012-09-08
• [Presentation] 慢性 GVHD の治療中に発症したクリプトコッカス髄膜炎の1例 (2012)
  • Author(s): 神尾卓哉、千葉奈歩、佐藤知彦、佐々木伸也、照井君典、伊藤悦朗
  • Organizer: 第115回日本小児科学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-04-20
• [Presentation] EMO異常症患児に認められた臍帯血移植後の変化(消化管病変を主に) (2012)
  • Author(s): 佐々木伸也、佐藤知彦、神尾卓哉、照井君典、伊藤悦朗、遠野千佳子、高橋良博
  • Organizer: 第34回日本造血細胞移植学会
  • Place of Presentation: 大阪
  • Year and Date: 2012-02-25
• [Presentation] ダウン症候群関連 ALL の発症における JAK2, および CRLF2 遺伝子異常の解析 (2011)
  • Author(s): 花田勇、照井君典、土岐力、工藤耕、佐藤知彦、神尾卓哉、佐々木伸也、高橋良博、林泰秀、杉田完爾、小島勢二、小池健一、小阪嘉之、小林正夫、伊藤悦朗
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] MLL遺伝子再構成陽性の小児急性リンパ性白血病のエクソーム解析 (2011)
  • Author(s): 堤修一、王凌〓、朴明子、照井君典、佐々木伸也、伊藤悦朗、林泰秀、油谷浩幸
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] Diamond-Blackfan anemia(DBA)乳児への Deferasirox の使用 (2011)
  • Author(s): 佐藤知彦、神尾卓哉、佐々木伸也、照井君典、土岐力、伊藤悦朗
  • Organizer: 第53回日本小児血液・がん学会学術集会
  • Place of Presentation: 前橋
  • Year and Date: 2011-11-25
• [Presentation] 当科で経験した小児成熟B細胞性腫瘍の9例 (2010)
  • Author(s): 佐々木伸也、佐藤知彦、神尾卓哉、照井君典、伊藤悦朗
  • Organizer: 第52回日本小児血液学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-17
• [Presentation] 遠隔転移を伴った Xp11 転座小児腎細胞癌の1例 (2010)
  • Author(s): 佐々木伸也、佐藤知彦、神尾卓哉、照井君典、伊藤悦朗、大山力、袴田健一、須貝道博、棟方博文
  • Organizer: 第62回北日本小児科学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-11
• [Book] 小児科学レクチャー2 (2013)
  • Author(s): 佐々木伸也、伊藤悦朗
  • Publisher: 血液系疾患の検査白血病. 総合医学社
• [Remarks]
  • URL: http://www.a-onclick.com/hirodai_syonika/