Development of molecular targeted therapy of bone marrow fibrosis with BACH1 transgenic mice
| Project/Area Number |
22591149
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Hirosaki University |
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Principal Investigator |
SASAKI Shinya 弘前大学, 医学部附属病院, 助教 (10344590)
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| Co-Investigator(Kenkyū-buntansha) |
TERUI Kiminori 弘前大学, 医学部附属病院, 講師 (00333740)
ITO Etsuro 弘前大学, 医学(系)研究科(研究院), 教授 (20168339)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 児血液学 / 骨髄線維症 / BACH1 / 転写因子 / トランスジェニックマウス / 血小板減少 / DNAマイクロアレイ / 分子標的療法 / HGF |
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| Research Abstract |
We performed this study using BACH1 transgenic mice (model mice for myelofibrosis) to understand the mechanism of myelofibrosis and develop the molecular target therapy, and found the following results
We identified the thromboxane A synthase gene as a BACH1 target in megakaryocytes.
We investigated the anti-myelofibrosis effects of hepatocyte growth factor, which has a function of suppressing fibrosis of various tissues, on BACH1 transgenic mice. However, no significant effects were observed.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Quantitative assessment of PTPN11 or RAS mutations at the neonatal period and during the clinical course in patients with juvenile myelomonocytic leukaemia.2009
Author(s)
Matsuda K, Sakashita K, Taira C, Tanaka-Yanagisawa M, Yanagisawa R, Shiohara M, Kanegane H, Hasegawa DKawasaki K, Endo M, Yajima S, Sasaki S, Kato K, Koike K, Kikuchi A, Ogawa A, Watanabe A, Sotomatsu M, Nonoyama S, Koike K
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Journal Title
Br J Haematol
Volume: 141
Issue: 4
Pages: 567-575
DOI
Related Report
Peer Reviewed
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