| Project/Area Number |
22591155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Shinshu University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Norimoto 信州大学, 医学部, 助教 (00362129)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 周期性発熱 / 自己炎症疾患 / CD64 / autoinflammatory disease / 炎症 / 発熱 / 治療 |
|---|
| Research Abstract |
The syndrome of periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) is the most common periodic fever disease in children. We examined clinical findings and the utility of CD64, namely Fcγ-RI expression on polymorphonuclear neutrophils and monocytes in diagnosing patients with PFAPA, Although CD64 was expressed at a similar level in the attack-free period of PFAPA and controls, CD64 expressions on both neutrophils and monocytes was dramatically increased during attacks. In addition, serum IFN-γ also increased in some PFAPA patients during flares, suggesting the involvement of T-cell activation. Our findings demonstrate that remarkable CD64 expression during PFAPA flares serves as a potential biomarker for the diagnosis.
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