| Project/Area Number |
22591157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ERA Seiichi 岐阜大学, 大学院・医学系研究科, 教授 (30152002)
MURAYAMA Koichi 岐阜大学, 大学院・医学系研究科, 助教 (30334931)
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| Co-Investigator(Renkei-kenkyūsha) |
TOMIDA Mihoko 松本歯科大学, 歯学部, 准教授 (00366329)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 高親和性 IgE 受容体β鎖 / 生物物理 / シグナル伝達 / アレルギー・ぜんそく / 蛋白質 |
|---|
| Research Abstract |
FcεRI β chain plays an important role in signal transduction of mast cells. We revealed that the secondary structure, conformation, and thermal stability of FcεRI βwild type, polymorphism, and mutants. In addition, we revealed that aspartic acid (D234) to alanine (β-D234A) significantly impaired IL-6 production but not degranulation. These data suggest a novel signaling pathway mediated by the cytoplasmic tail downstream of the FcεRI β ITAM.
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