Carcinogenesis of human neuroblastoma from human neural stem cell
| Project/Area Number |
22591165
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya City University |
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Principal Investigator |
AOYAMA Mineyoshi 名古屋市立大学, 大学院・医学研究科, 講師 (70363918)
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| Co-Investigator(Kenkyū-buntansha) |
ASAI Kiyofumi 名古屋市立大学, 大学院・医学研究科, 教授 (70212462)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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|---|
| Keywords | 神経芽細胞腫 / ヒト神経幹細胞 / ヒト iPS 細胞 / N-myc 遺伝子 / 腫瘍発生 / ヒトiPS細胞 / N-myc遺伝子 |
|---|
| Research Abstract |
We have made human neural stem cell from human iPS cell and investigated whether the induction of exogenous oncogene N-myc could transform the cell or not. We would prepare human or mouse neural stem cells at various step of the development. And N-myc genes were induced in the cells. The effect on cell proliferation was observed. These studies may reflect the cellular transformation from the normal cells to the cancer cells to clarify the mechanism of the carcinogenesis.
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Report
(4 results)
Research Products
(56 results)
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[Journal Article] Eras enhances resistance to CPT-11 in gastric cancer.2011
Author(s)
Kubota E, Kataoka H, Tanaka M, Okamoto Y, Ebi M, Hirata Y, Murakami K, Mizoshita T, Shimura T, Mori Y, Tanida S, Kamiya T, Aoyama M, Asai K, Joh T.
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Journal Title
Anticancer Res
Volume: 31
Pages: 3353-60
URL
Related Report
Peer Reviewed
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[Journal Article] Role of ES Cell-Expressed Ras (ERas) in Tumorigenicity of Gastric Cancer.2010
Author(s)
Kubota E, Kataoka H, Aoyama M, Mizoshita T, Mori Y, Shimura T, Tanaka M, Sasaki M, Takahashi S, Asai K, Joh T
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Journal Title
Am J Pathol
Volume: 177
Issue: 2
Pages: 955-963
DOI
Related Report
Peer Reviewed
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