Proteomic analysis of phosphorylation in leukemic cells

• Project/Area Number: 22591168
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Keio University
• Principal Investigator: SHIMADA Hiroyuki 慶應義塾大学, 医学部, 講師 (80265868)
• Co-Investigator(Kenkyū-buntansha): YOSHIHARA Hiroki 慶應義塾大学, 医学部, 共同研究員 (90348706) ; SHIMA Haruko 慶應義塾大学, 医学部, 助教 (80424167)
• Co-Investigator(Renkei-kenkyūsha): ISHIHAMA Yasushi 京都大学, 薬学研究科(研究院), 教授 (30439244) ; KITABAYASHI Kazuo 国立がんセンター, 分子腫瘍学部, 部長 (20261175)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児腫瘍学 / 癌 / 生体分子 / プロテオーム / リン酸化 / 白血病

Research Abstract

Protein phosphorylation is a crucial regulatory posttranslational modification in eukaryotes. Mass spectrometric methods have been improved to obtain a snapshot of the phosphoproteomes to pave the way for in-depth mapping of phosphorylation sites. By inno

Research Products

• [Presentation] Phosphoproteomic profiling of leukemia cells (2010)
  • Author(s): Yoshihara H, Shimada H, Shima H, Tomita M, Ishihama Y
  • Organizer: 15th European Hematology Association congress
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-06-11
• [Presentation] PHOSPHOPROTEOMIC PROFILING OF LEUKEMIA CELLS (2010)
  • Author(s): 吉原宏樹
  • Organizer: 15th European Hematology Association congress
  • Place of Presentation: バルセロナ
  • Year and Date: 2010-06-11