DNA mismatch repair deficiency in paediatric haematological malignancies: research and application for chemotherapeutic strategies
| Project/Area Number |
22591173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | National Hospital Organization, Kyushu Cancer Center |
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Principal Investigator |
OKAMURA Jun 独立行政法人国立病院機構(九州がんセンター臨床研究センター), その他の部局等 (40360854)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 小児腫瘍学 / 血液腫瘍 / 化学療法 / 薬剤反応性 / DNA 修復 / 癌 / DNA修復 |
|---|
| Research Abstract |
This study aimed to elucidate the reality of DNA mismatch repair (MMR) deficiency in the paediatric haematological malignancies, particularly acute lymphocytic leukaemia (ALL) and non-Hodgkin lymphoma, and, consequently, the relationship between the MMR status and the chemosensitivity of tumours against methotrexate (MTX) and 6-mercatutopurine (6-MP) in this category of human malignancies. In a panel of 30 ALL patients, we analysed microsatellite instability (MSI) in the tumour DNA and found a few MSI-positive tumours. However, the detailed examination of the clinical backgrounds of the patients revealed that the observed microsatellite alterations reflected the haematopoietic stem cell transplantation that they underwent, which suggests that MSI analysis is not applicable to some cases of haematological malignancies. Multi-angle analysis is needed in this subject.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Social outcomes and quality of life of childhood cancer survivors in Japan: a cross-sectional study on marriage, education, employment and health-related QOL (SF-36)2011
Author(s)
Ishida Y, Honda M, Kamibeppu K, Ozono S, Okamura J, Asami K, Maeda N, Sakamoto N, Inada H, Iwai T, Kakee N, Horibe K.
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Journal Title
Int J Hematol
Volume: 93
Issue: 5
Pages: 635-644
DOI
NAID
Related Report
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[Journal Article] Transplantation of allogeneic hematopoietic stem cells for adult T-cell leukemia: a nationwide retrospective study2010
Author(s)
Hishizawa M, Kanda J, Utsunomiya A, Taniguchi S, Eto T, Moriuchi Y, Tanosaki R, Kawano F, Miyazaki Y, Masuda M, Nagafuji K, Hara M, Takanashi M, Kai S, Atsuta Y, Suzuki R, Kawase T, Matsuo K, Nagamura-Inoue T, Kato S, Sakamaki H, Morishima Y, Okamura J, Ichinohe T, Uchiyama T
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Journal Title
Blood
Volume: 116
Issue: 8
Pages: 1369-1376
DOI
Related Report
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[Journal Article] Late effects and quality of life of childhood cancer survivors: Part 2. Impact of radiotherapy2010
Author(s)
Ishida Y, Sakamoto N, Kamibeppu K, Kakee N, Iwai T, Ozono S, Maeda N, Okamura J, Asami K, Inada H, Honda M, Horibe K
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Journal Title
Int J Hematol
Volume: 92
Issue: 1
Pages: 95-104
DOI
NAID
Related Report
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[Presentation] Identification of a novel HLA-DR1-retricted dominant epitope recognized by HTLV-1 Tax-specific CD4+ T-cells augmenting HTLV-1-specific CTL expansion in ATL patients after allogeneic HSCT2013
Author(s)
Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Eto T, Koh K, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M
Organizer
The 9th Joint Conference of the American Association forCancer Research and the Japanese Cancer Association
Place of Presentation
Maui
Year and Date
2013-02-21
Related Report
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[Presentation] Identification of a novel HLA-DR1-restricted epitope that is recognized by Tax-specific CD4+ T cells with the potential to enhance Tax-specific CD8+ responses in ATL patients after allo-HSCT2012
Author(s)
Tamai Y, Hasegawa A, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Etoh T, Koh H, Suehiro Y, Okamura J, Uike N, Kannagi M
Organizer
第71回日 本癌学会総会
Place of Presentation
札幌
Year and Date
2012-09-19
Related Report
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[Presentation] A prospective Feasibility trial of unrelated bone marrow transplantation with reduced intensity conditioning regimen for elderly patients with adult T-cell leukemia/lymphoma (ATL)2011
Author(s)
Eto T, Choi I, Tanosaki R, Takatsuka Y, Utsunomiya A, Takemoto S, Taguchi J, Fukushima T, Kato K, Teshima T, Suehiro Y, Yamanaka T, Okamura J, Uike N
Organizer
53th American Society of Hematology Annual meeting and Exposition
Place of Presentation
San Diego
Year and Date
2011-12-10
Related Report
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[Presentation] Functional impairment of Tax-specific but not CMV-specific CTLs in a minor population of asymptomatic HTLV-I-carriers2011
Author(s)
Hasegawa A, Takamori A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi
Organizer
15th International Conference on Human Retrovirology
Place of Presentation
Leuven
Year and Date
2011-06-05
Related Report
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[Presentation] Can allo-SCT with RIC cure ATLL?2011
Author(s)
Uike N, Tanosaki R, Utsunomiya A, Choi I, Okamura J
Organizer
Long-term survivors with excellent PS and with heterogenous HTLV-1 proviral load level
Place of Presentation
Leuven
Year and Date
2011-06-05
Related Report
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