Macrophage as a therapeutic target for chronic kidney diseases
Project/Area Number |
22591177
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Niigata University |
Principal Investigator |
IKEZUMI Yohei 新潟大学, 医歯学総合病院, 講師 (70361897)
|
Co-Investigator(Kenkyū-buntansha) |
KAWACHI Hiroshi 新潟大学, 医歯学系, 教授 (60242400)
SUZUKI Toshiaki 新潟大学, 医歯学総合病院, 助教 (50419305)
KARASAWA Tamaki 新潟大学, 医歯学総合病院, 特任助教 (30447601)
|
Co-Investigator(Renkei-kenkyūsha) |
NARITA Ichiei 新潟大学, 医歯学系, 教授 (20272817)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 小児腎・泌尿器学 / 慢性腎疾患 / 活性化マクロファージ / M1 / M2 / 高脂血症 / 線維化 / 難治性ネフローゼ症候群 / 難治性腎炎 / ステロイド抵抗性ネフローゼ症群 |
Research Abstract |
Macrophage accumulation typically observed during progression of all kidney diseases and is potentially involved in the development of clinico-histopathological abnormalities observed as the disease progresses. These findings suggest that macrophages could be an important therapeutic target for chronic kidney diseases although their roles at the site of kidney lesion remain to be elucidated. We studied the mechanism of activated macrophage-mediated kidney injury using renal biopsy tissue, experimental model and culture system. Our studies on activated macrophages revealed that different macrophage phenotypes (M1 and M2) are involved in chronic glomerulonephritis with specific roles in different phases and lesions. The M1-activated macrophage, a pro-inflammatory phenotype, appeared to play a role in acute glomerular injury and was detected in active glomerular lesions such as cellular glomerular crescents and glomerular cell proliferations, and was suppressed by glucocorticoids. In contrast, the M2-activated phenotype, an anti-inflammatory phenotype, was more predominant in sites with chronic lesions such as glomerular sclerotic lesions and interstitial fibrosis, and was rather activated by glucocorticoids. Thus, macrophage phenotype-specific targeting, timing of treatment, and choice of therapeutic agents are vital in the prevention of macrophage-mediated renal injury.
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Report
(4 results)
Research Products
(53 results)
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[Journal Article] Nonadherenceを原因とする拒絶反応から、移植腎機能低下をきたした13歳男子例思春期における腎移植後患児のNonadherenceについて2012
Author(s)
鈴木俊明,池住洋平,唐澤環,長谷川博也,中川由紀,斉藤和英,高橋公太,石原俊二,原正則,柳原俊雄,内山聖
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Journal Title
日本小児腎臓病学会雑誌
Volume: 25
Pages: 58-62
NAID
Related Report
Peer Reviewed
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[Journal Article] Identification of alternativelyactivated macrophages in new-onset paediatric and adult immunoglobulinA nephropathy: potential role in mesangial matrix expansion2011
Author(s)
Ikezumi Y,Suzuki T,Karasawa T, Hasegawa H,Yamada T,Imai N, Narita I,Kawachi H,Polkinghorne KR, Nikolic-Paterson DJ,Uchiyama M
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Journal Title
Histopathology
Volume: 58
Pages: 198-210
Related Report
Peer Reviewed
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[Journal Article] Neurexin-1, a presynaptic adhesion molecule, localizes at the slit diaphragm of the glomerular podocytes in kidneys2011
Author(s)
Saito A,Miyauchi N,Hashimoto T,Karasawa T,Han GD,Kayaba M,Sumi T,Tomita M,Ikezumi Y,Suzuki K,Koitabashi Y,Shimizu F,Kawachi H
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Journal Title
Am J Physiol Regul Integr Comp Physiol
Volume: 300
Related Report
Peer Reviewed
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