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Investigation of inflammatory mechanism inKawasaki disease using co-culture in vitro vascular model

Research Project

Project/Area Number 22591184
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionSaga University

Principal Investigator

TASHIRO Katsuya  佐賀大学, 医学部, 講師 (70295046)

Co-Investigator(Kenkyū-buntansha) HAMASAKI Yuhei  佐賀大学, 医学部, 教授 (10172967)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords小児循環器 / 川崎病 / 血管病変 / 単球活性化 / 脂肪細胞 / U937 単球様細胞 / 臍帯血管内皮細胞 / 共培養 / SAA / 単球 / 炎症
Research Abstract

Kawasaki disease (KD) is a systemic vasculitis in children. In this project, we tried to established one of in vitro culture models which clarified inflammatory processes of KD. Furthermore, we intended to find adequate therapeutic plan for vasculitis in KD. We examined co-culture experiments using cells which are basic components in coronary arteries. Our co-culture experiments used lipoblastid 3T3 cells, U937 monocytic cells and umbilical vein endothelial cells. Any type of combination co-cultures showed that cell-to-cell contact strongly activated various cell functions closely related with inflammatory process. Our results indicate progression of inflammatory reaction in our body would be accelerated by cell-to-cell cross talk.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (4 results)

  • [Journal Article] Yersinia pseudotuberculosis5a抗体価上昇が認められた腸間膜リンパ節膿瘍の1例2012

    • Author(s)
      熊本崇
    • Journal Title

      日本小児科学会雑誌

      Volume: 116 Pages: 1549-1553

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 佐賀における学校心臓検診について。その現状と今後の課題2011

    • Author(s)
      田代克弥、漢伸彦、西村真二、橋野かの子、福田省史、田崎考
    • Journal Title

      佐賀県小児科医報

      Volume: 25 Pages: 28-30

    • Related Report
      2011 Annual Research Report
  • [Presentation] 川崎病急性期における血清アミロイドAの有用性2012

    • Author(s)
      田代克弥
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] Metabolic Acidosis Caused by Rotavirus Gastroenteritis would Give Fatal Damage on Young Children2011

    • Author(s)
      Katsuya Tashiro
    • Organizer
      2011 Pediatric Academic Societies & Asian Society for Pediatric Research Joint Meeting
    • Place of Presentation
      Denver, CO, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] ロタウイルス感染症における体重減少率とBase Excessについての検討2011

    • Author(s)
      田代克弥
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 川崎病急性期治療における抗TNF-α阻害剤の作用機序の解明2010

    • Author(s)
      田代克弥
    • Organizer
      2010年 川崎病治療懇話会
    • Place of Presentation
      千葉県浦安市
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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