Impact of Congenital Cytomegalovirus and Human Herpersvirus-6Infections: A Cohort Study in Nagasaki Prefecture

• Project/Area Number: 22591185
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Nagasaki University
• Principal Investigator: MORIUCHI Masako 長崎大学, 大学院・医歯薬学総合研究科, 助教 (60322301)
• Co-Investigator(Kenkyū-buntansha): MORIUCHI Hiroyuki 長崎大学, 大学院・医歯薬学総合研究科, 教授 (90315234)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 小児感染症学 / ウイルス / 感染症 / 臨床 / 社会医学

Research Abstract

We have registered infants and toddlers who were born or lived in Nagasaki Prefecture with any of the following medical problems: bilateral profound sensorineural hearing loss, congenital hydrocephalus, refractory epilepsy (mostly, West syndrome) and pervasive developmental disorder (PDD).We collected their dried umbilical cord or dried blood spot specimens for detection of cytomegalovirus (CMV) and human herpesvirus-6 (HHV-6) DNA. We could demonstrate congenital CMV infection in some of those infants including two children with PDD; however, HHV-6 DNA was not detected from any of those specimens.

Research Products

• [Journal Article] Newborn screening of congenital cytomegalovirus infection using saliva can be influenced by breast feeding (2013)
  • Author(s): Koyano S, Moriuchi H
  • Journal Title: Arch Dis Child Fetal Ed Volume: vol.98
  • Peer Reviewed
• [Journal Article] Mother-to-child transmission of human T-cell leukemia virus type I (2013)
  • Author(s): Moriuchi H (他3名)
  • Journal Title: Pediatr Infect Dis J Volume: vol.32 Pages: 175-177
  • Peer Reviewed
• [Journal Article] Newborn screening of congenital cytomegalovirus infection using saliva can be influenced by breast feeding (2013)
  • Author(s): Shin Koyano
  • Journal Title: Archives of disease in childhood. Fetal and neonatal edition Volume: 98(2) Issue: 2 Pages: F182.1-F182
  • DOI: 10.1136/archdischild-2012-302230
  • Peer Reviewed
• [Journal Article] Mother-to-child transmission of human T-cell leukemia virus type I (2013)
  • Author(s): Hiroyuki Moriuchi
  • Journal Title: Pediatric Infectious Disease Journal Volume: 32(2) Issue: 2 Pages: 175-177
  • DOI: 10.1097/inf.0b013e31827efc39
  • Peer Reviewed
• [Journal Article] for the Japanese Congenital Cytomegalovirus Study Group. Screening for congenital cytomegalovirus infection using newborn urine samples collected on filter paper: feasibility and outcomes from a multicenter study. (2011)
  • Author(s): Koyano S, Inoue N, Oka A, Moriuchi H, (他5名)
  • Journal Title: BMJ Open Volume: 1 Pages: 000118-000118
  • Peer Reviewed
• [Journal Article] 気をつけなければならない小児感染症の管理、最近の考えは?先天性サイトメガロウイルス感染症 (2011)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: 小児科臨床 Volume: 64巻 Pages: 2575-2581
• [Journal Article] Maternal body mass index and gestational weight gain and their association with perinatal outcomes in Viet Nam (2011)
  • Author(s): Ota E, Haruna M, Suzuki M, Anh DD, Tho LH, Tam NTT, Thiem VD, Hien Anh NT, Isozaki M, Shibuya K, Ariyoshi K, Murashima S, Moriuchi H, Yanai H
  • Journal Title: Bulletin of World Heath Organization Volume: 89 Pages: 127-136
  • Peer Reviewed
• [Journal Article] 母子感染HIV感染とHTLV感染 (2011)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: 臨床と微生物 Volume: 38 Pages: 667-673
• [Journal Article] ヒトT細胞白血病ウイルスI型 (2011)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: 周産期医学 Volume: 41 Pages: 230-234
• [Journal Article] Seroepidemiological survey of cytomegalovirus infection among pregnant women in Nagasaki, Japan (2010)
  • Author(s): Tagawa M, Minematsu T, Masuzaki H, Ishimaru T, Moriuchi H
  • Journal Title: Pediatr Int Volume: vol.52 Pages: 459-462
  • NAID: 10028182884
  • Peer Reviewed
• [Journal Article] Detection of cytomegalovirus in preserved umbilical cord from a boy with autistic disorder (2010)
  • Author(s): Kawatani M, Nakai A, Okuno T, Kobata R, Moriuchi M, Moriuchi H, et al.
  • Journal Title: Pediatr Int Volume: vol.52 Pages: 304-307
  • NAID: 10028182222
  • Peer Reviewed
• [Journal Article] 話題の感染症:母子感染するウイルス～共生か矯正か (2010)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: モダンメディア Volume: 56巻 Pages: 153-158
• [Journal Article] 新時代のワクチン戦略について考える～ (2010)
  • Author(s): 森内昌子
  • Journal Title: ヘルペス・サイトメガロウイルス.日本臨床 Volume: 54巻増刊号別冊 Pages: 1400-1406
• [Journal Article] ウイルス性母子感染症 (2010)
  • Author(s): 森内昌子、森内浩幸
  • Journal Title: 化学療法の領域 Volume: 26巻 Pages: 2353-2362
• [Journal Article] Seroepidemiological Survey of Cytomegalovirus Infection among Pregnant Women in Nagasaki, Japan. (2010)
  • Author(s): Tagawa M, Minematsu T, Masuzaki H, Ishimaru T, Moriuchi H.
  • Journal Title: Pediatr Int. Volume: 52 Pages: 459-462
  • NAID: 10028182884
  • Peer Reviewed
• [Journal Article] Detection of cytomegalovirus in preserved umbilical cord from aboy with autistic disorder. (2010)
  • Author(s): Kawatani M, Nakai A, Okuno T, Kobata R, Moriuchi M, Moriuchi H, et al.
  • Journal Title: Pediatr Int. Volume: 52 Pages: 304-307
  • Peer Reviewed
• [Journal Article] 新時代のワクチン戦略について考える～ヘルペス・サイトメガロウイルス (2010)
  • Author(s): 森内昌子
  • Journal Title: 日本臨床 Volume: 54増刊号別冊 Pages: 1400-1406
• [Presentation] Clinicoepidemiological states of congenital cytomegalovirus infection: a nationwide survey in Japan (2012)
  • Author(s): Moriuchi H, (他3名)
  • Organizer: 4thCongenital CMV Conference
  • Place of Presentation: サンフランシスコ(USA).
• [Presentation] A birth cohort study on congenital cytomegalovirus infection in Khanh Hoa Province, Vietnam (2011)
  • Author(s): Motomura H, Miyakawa M, Moriuchi M, Yoshino H, Yoshida LM, Minematsu T, Tho LH, Ariyoshi K, Anh DD, Moriuchi H
  • Organizer: Pediatric Academic Societies/ Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] Mother-to-child transmission of cytomegalovirus and human T-cell leukemia virus (2011)
  • Author(s): Moriuchi M, Moriuchi H
  • Organizer: Pediatric Academic Societies/ Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] A Birth Cohort Study on Congenital Cytomegalovirus Infection in Khanh Hoa Province, Vietnam (2011)
  • Author(s): Motomura H, Miyakawa M, Moriuchi M, Yoshino H, Yoshida LM, Minematsu T, Tho LH, Ariyoshi K, Anh DD, Moriuchi H
  • Organizer: Pediatric Academic Societies/Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] Mother-to-child transmission of cytomegalovirus and human T-cell leukemia virus (2011)
  • Author(s): Moriuchi H, Moriuchi M
  • Organizer: Pediatric Academic Societies/Asian Society for Pediatric Research Joint Meeting
  • Place of Presentation: デンバー(USA)
• [Presentation] A retrospective diagnosis of congenital CMV infection in Japanese children with pervasive developmental disorders using dried umbilical cord (2010)
  • Author(s): Moriuchi M, Sakamoto A, Motoyama K, Matsuzaki J, Moriuchi H
  • Organizer: 3rdCongenital CMVConference 2010
  • Place of Presentation: パリ(フランス)
• [Presentation] A multi-center study on the treatment of congenital CMV in Japan (2010)
  • Author(s): Moriuchi H, (他10名)
  • Organizer: 3rdCongenital CMV Conference 2010
  • Place of Presentation: パリ(フランス)
• [Presentation] A retrospective diagnosis of congenital CMV infection in Japanese children with pervasive developmental disorders using dried umbilical cord. (2010)
  • Author(s): Moriuchi M, Samamoto A, Motoyama K, Matsuzaki J, Moriuchi H
  • Organizer: 3^<rd> Congenital CMV Conference 2010
  • Place of Presentation: パリ(フランス)
• [Presentation] 先天性サイトメガロウイルス感染の実態調査 (2010)
  • Author(s): 森内昌子、宮川雅美、森内浩幸, 他
  • Organizer: 3^<rd> Congenital CMV Conference 2010
  • Place of Presentation: パリ(フランス)