| Project/Area Number |
22591187
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Pediatrics
|
|---|
| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
SATO Masatoki 福島県立医科大学, 医学部, 講師 (60423795)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
光亮 Mitsuaki 福島県立医科大学, 医学部, 教授 (80192318)
HASHIMOTO Kouichi 福島県立医科大学, 医学部, 准教授 (50322342)
OHARA Shinichiro 福島県立医科大学, 医学部, 助教 (00566846)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | インフルエンザ / アポトーシス / プロテアーゼ / セリンプロテアーゼ |
|---|
| Research Abstract |
Influenza viruses induce the cell death to the host cell after infection and the viruses replicated acquire their infectivity using the protease derived from the host cells. In this study, the relation between the cell death induced by influenza virus infection and its replication was studied. As one of results, the novel virus replication mechanism, influenza viruses exploit one of the proteases to acquire infectivity which is induced after infection and contribute to the cell death, is suggested.
|
