The study for the potential therapeutic option of targeting apelin-APJ system for renal fibrosis
| Project/Area Number |
22591189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
NISHIDA Masashi 京都府立医科大学, 医学研究科, 講師 (50275202)
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| Co-Investigator(Kenkyū-buntansha) |
HAMAOKA Kenji 京都府立医科大学, 医学研究科, 教授 (60189602)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 腎線維化 / Apelin / APJ receptor / UUO / Nitric Oxide / アンギオテンシン II / アンギオテンシン受容体拮抗薬 / アンギオテンシンII / eNOS |
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| Research Abstract |
In a mouse model of unilateral ureteral obstruction-induced renal fibrosis, the experiments with subcutaneous administration of apelin suggested that the apelin-APJ system exerts renoprotective effect through increased NO production viaAkt-eNOS pathway. Furthermore, treatments with losartan and an APJ receptor antagonistin this model suggested that the renoprotective effect with losartan treatment is, at least in part, through the apelin-APJ system
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Report
(4 results)
Research Products
(18 results)
