The study for the potential therapeutic option of targeting apelin-APJ system for renal fibrosis

• Project/Area Number: 22591189
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: NISHIDA Masashi 京都府立医科大学, 医学研究科, 講師 (50275202)
• Co-Investigator(Kenkyū-buntansha): HAMAOKA Kenji 京都府立医科大学, 医学研究科, 教授 (60189602)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腎線維化 / Apelin / APJ receptor / UUO / Nitric Oxide / アンギオテンシン II / アンギオテンシン受容体拮抗薬 / アンギオテンシンII / eNOS

Research Abstract

In a mouse model of unilateral ureteral obstruction-induced renal fibrosis, the experiments with subcutaneous administration of apelin suggested that the apelin-APJ system exerts renoprotective effect through increased NO production viaAkt-eNOS pathway. Furthermore, treatments with losartan and an APJ receptor antagonistin this model suggested that the renoprotective effect with losartan treatment is, at least in part, through the apelin-APJ system

Research Products

• [Journal Article] The Apelin-APJ system: its role in renal physiology and potential therapeutic applications for renal disease (2013)
  • Author(s): Nishida M, Hamaoka K
  • Journal Title: OA Nephrology Volume: 01 Pages: 1-7
  • URL: http://www.oapublishinglondon.com/oa-nephrology
  • Peer Reviewed
• [Journal Article] The role of apelin on the alleviative effect of angiotensin receptor blocker in unilateral ureteralobstruction-induced renal fibrosis (2012)
  • Author(s): Nishida M, Okumura Y, Oka T, Toiyama K, Ozawa S, Itoi T, Hamaoka K
  • Journal Title: Nephron Extra Volume: 2 Issue: 1 Pages: 39-47
  • DOI: 10.1159/000337091
  • Peer Reviewed
• [Journal Article] Exogenous apelin ameliorates renal fibrosis in obstructive nephropathy (2012)
  • Author(s): Nishida M, Okumura Y, Oka T, Toiyama K, Ozawa S, Itoi T
  • Journal Title: Current Topics in Biochemical Research Volume: 14 Pages: 17-24
  • URL: http://www.researchtrends.net/tia/volumes.asp?id=40
  • Peer Reviewed
• [Journal Article] Exogenous apelin ameliorates renal fibrosis in obstructive nephropathy. (2012)
  • Author(s): Nishida M, Okumura Y, Oka T, Toiyama K, Ozawa S, Itoi T, Hamaoka K
  • Journal Title: Current Topics in Biochemical Research Volume: 14 Pages: 17-24
  • Peer Reviewed
• [Journal Article] The apelin-APJ and renin-angiotensin systems (2011)
  • Author(s): Nishida M, Hamaoka K
  • Journal Title: Current Topics in Biochemical Research Volume: 13 Pages: 21-25
  • URL: http://www.researchtrends.net/tia/volumes.asp?id=40
  • Peer Reviewed
• [Journal Article] Serum and urinary neutrophil gelatinase-associated lipocalin levels in children with chronic renal diseases. (2010)
  • Author(s): Nishida M, Kawakatsu H, Okumura Y, Hamaoka K
  • Journal Title: Pediatr Int Volume: 52 Pages: 563-568
  • NAID: 10028183346
  • Peer Reviewed
• [Presentation] The role of apelin for the alleviative effect of angiotensin receptor blocker in UUO-induced renal fibrosis. The 11th Asian Congress of Pediatric (2011)
  • Author(s): Nishida M, Okumura Y, Hamaoka K
  • Organizer: Nephrology
  • Place of Presentation: Fukuoka
• [Presentation] UUO腎線維化モデルにおける ARB 投与時のApelin の役割 (2011)
  • Author(s): 西田眞佐志、奥村保子、〓岡建城
  • Organizer: 第54回日本腎臓学会総会
  • Place of Presentation: 横浜
• [Presentation] The role of apelin for the alleviative effect of angiotensin receptor blocker in UUO-induced renal fibrosis (2011)
  • Author(s): Nishida M, Okumura Y, Hamaoka K
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: Fukuoka
• [Presentation] UUO腎線維化モデルにおけるARB投与時のApelinの役割 (2011)
  • Author(s): 西田眞佐志、奥村保子、濱岡建城
  • Organizer: 第54回日本腎臓学会
  • Place of Presentation: 横浜
• [Presentation] The effects of apelin on obstructive nephropathy (2010)
  • Author(s): Nishida M, Okumura Y, Hamaoka K
  • Organizer: The 43rd Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Denver, CO, USA
• [Presentation] UUOモデルの腎線維化における内因性Apelin の役割 (2010)
  • Author(s): 西田眞佐志、奥村保子、〓岡建城
  • Organizer: 第53回日本腎臓学会総会
  • Place of Presentation: 神戸
• [Presentation] UUOモデルの腎線維化における内因性Apelin の役割 (2010)
  • Author(s): 西田眞佐志、奥村保子、〓岡建城
  • Organizer: 第45回日本小児腎臓病学会
  • Place of Presentation: 大阪
• [Presentation] The effects of apelin on obstructive nephropathy. (2010)
  • Author(s): Nishida M, Okumura Y, Hamaoka K
  • Organizer: The 43rd Annual Meeting of the American Society of Nephrology
  • Place of Presentation: Denver, CO, USA
• [Presentation] UUOモデルの腎線維化における内因性Apelinの役割 (2010)
  • Author(s): 西田眞佐志、奥村保子、濱岡建城
  • Organizer: 第53回日本腎臓学会
  • Place of Presentation: 神戸
• [Presentation] UUOモデルの腎線維化における内因性Apelinの役割 (2010)
  • Author(s): 西田眞佐志、奥村保子、濱岡建城
  • Organizer: 第45回日本小児腎臓病学会
  • Place of Presentation: 大阪
• [Presentation] 腎線維化の進展に対する Apelin の影響 (2009)
  • Author(s): 西田眞佐志、奥村保子、〓岡建城
  • Organizer: 第52回日本腎臓学会総会
  • Place of Presentation: 横浜
• [Presentation] 腎線維化の進展に対する Apelin の影響 (2009)
  • Author(s): 西田眞佐志、奥村保子、〓岡建城
  • Organizer: 第44回日本小児腎臓病学会
  • Place of Presentation: 東京