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New approach for the elucidation of the etiology of Kawasaki disease

Research Project

Project/Area Number 22591190
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionWakayama Medical University

Principal Investigator

SUZUKI Hiroyuki  和歌山県立医科大学, 医学部, 准教授 (80196865)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Norishige  和歌山県立医科大学, 医学部, 教授 (10158412)
TAKEUCHI Takashi  和歌山県立医科大学, 医学部, 講師 (10246522)
SUENAGA Tomohiro  和歌山県立医科大学, 医学部, 助教 (70433365)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小児循環器学 / 川崎病 / スーパー抗原 / 口腔内常在菌 / 遺伝子転移
Research Abstract

We collected the samples of throat swab from 58 patients who met the diagnostic criteria for Kawasaki disease and were admitted to our hospitals. Bacteria from throat swab were cultured in liquid culture solution (Brain-Heart-Infusion). W e extracted total DNA from those bacteria using DNA Mini Kit (QIAGEN). Using total DNA extracted from bacteria as a template, polymerase chain reaction (PCR) was performed for 5 SAg genes-streptococcal pyrogenic exotoxin type A(SPE-A), SPE-C, SPE-G, SPE-J, and toxic shock syndrome toxin-1 (TSST -1). SPE-G gene and SPE-J gene were detected in 7 and 6 of 58 patients, respectively. Both SPE-G gene and SPE-J gene were detected in one of 58 patients. Thus, gene fragments of superantigens derived from group A streptococcus (GAS) were detected in the samples of throat swabs from 12 of 58 patients (20.7%). These results were reproducted and very important. However, GAS was not detected from any patients in whom SPE-G and SPE-J gene were detected. Thus, it is very important point and the theme in this study that any kind of bacteria have these superantigen genes. Unfortunately, we could not isolate the bacteria in this study.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (54 results)

All 2013 2012 2011 2010

All Journal Article (26 results) (of which Peer Reviewed: 14 results) Presentation (28 results) (of which Invited: 1 results)

  • [Journal Article] 川崎病の治療2013

    • Author(s)
      鈴木啓之
    • Journal Title

      日本臨床(増刊号)

      Pages: 132-136

    • Related Report
      2012 Final Research Report
  • [Journal Article] 免疫抑制剤シクロスポリン Aの有用性2013

    • Author(s)
      鈴木啓之
    • Journal Title

      小児科臨床

      Volume: 66(1) Pages: 25-31

    • Related Report
      2012 Final Research Report
  • [Journal Article] 免疫抑制剤シクロスポリンAの有用性2013

    • Author(s)
      鈴木啓之
    • Journal Title

      小児科臨床

      Volume: 66 Pages: 25-31

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 川崎病の治療2013

    • Author(s)
      鈴木啓之
    • Journal Title

      日本臨床

      Volume: 増刊号 Pages: 132-136

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 川崎病急性期治療ガイドライン2012

    • Author(s)
      佐地 勉、鮎澤 衛、三浦 大、小林 徹、鈴木啓之、森 雅亮、寺井 勝、小川俊一
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 28 Pages: 1-28

    • Related Report
      2012 Final Research Report
  • [Journal Article] IVIG 不応川崎病症例に対する CsA 療法時の血中カリウム濃度の検討2012

    • Author(s)
      垣本信幸、 鈴木啓之、 末永智浩、 武内 崇、吉川徳茂、渋田昌一、濱田洋通、本田隆文、寺井 勝、笹子久美子、尾内善広、鈴木洋一、羽田 明
    • Journal Title

      Prog Med

      Volume: 32 Pages: 1469-1473

    • Related Report
      2012 Final Research Report
  • [Journal Article] Japan Kawasaki disease Genome Consortium & US Kawasaki disease Genetics Consortium,: A genome-wide association study identifies three new risk loci for Kawasaki disease.2012

    • Author(s)
      Onouchi Y, Ozaki K, Burns JC, Shimizu C, Terai M, Hamada H, Honda T, Suzuki H, Suenaga T, Takeuchi T, Yoshikawa N, Suzuki Y, Yasukawa K, Ebata R, Higashi K, Saji T, Kemmotsu Y, Takatsuji S, Ouchi K, Kishi F, Yoshikawa T, Nagai T, Hamamoto K, Sato Y, Honda A, Kobayashi H, Sato J, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Iwahashi S, Miyashita R, Murata Y, Sasago K, Takahashi A, Kamatani N, Kubo M, Tsunoda T, Hata A, Nakamura Y, Tanaka T
    • Journal Title

      Nature Genetics

      Volume: 44 (5) Pages: 517-521

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory cytokine profiles during Cyclosporin treatment for immunoglobulin-resistant Kawasaki disease2012

    • Author(s)
      Hamada H, Suzuki H, Abe J, Suzuki Y, Suenaga T, Takeuchi T, Yoshikawa N, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Iwahashi S, Miyashita R, Honda A, Onouchi Y, Terai M, and Hata.A
    • Journal Title

      Cytokine

      Volume: 60 Pages: 681-685

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammatory cytokine profiles during Cyclosporin treatment for immunoglobulin-resistant Kawasaki disease.2012

    • Author(s)
      Hamada H et al.
    • Journal Title

      Cytokine

      Volume: 60 Issue: 3 Pages: 681-685

    • DOI

      10.1016/j.cyto.2012.08.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IVIG不応川崎病症例に対するCsA療法時の血中カリウム濃度の検討2012

    • Author(s)
      垣本信幸 他
    • Journal Title

      Prog Med

      Volume: 32 Pages: 1469-1473

    • Related Report
      2012 Annual Research Report
  • [Journal Article] A genome-wide association study identifies three new risk loci for Kawasaki disease2012

    • Author(s)
      Onouchi Y, et al
    • Journal Title

      Nat Genet

      Volume: 44 Issue: 5 Pages: 517-521

    • DOI

      10.1038/ng.2220

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 川崎病の本態にせまる -古くて新しい研究から-肝機能障害2011

    • Author(s)
      鈴木啓之
    • Journal Title

      小児科診療

      Volume: 74 (8) Pages: 1133-1136

    • Related Report
      2012 Final Research Report
  • [Journal Article] 川崎病の病因における新たな展望 -川崎病はスーパー抗原病?-2011

    • Author(s)
      鈴木啓之
    • Journal Title

      Prog Med

      Volume: 31 Pages: 1688-1691

    • Related Report
      2012 Final Research Report
  • [Journal Article] 当院で経過観察中の川崎病巨大冠動脈瘤合併例の検討2011

    • Author(s)
      末永智浩、 鈴木啓之、 武内 崇、垣本信幸、吉川徳茂、打田俊司、岡村吉隆、渋田昌一
    • Journal Title

      Prog Med

      Volume: 31 Pages: 1700-1703

    • Related Report
      2012 Final Research Report
  • [Journal Article] Cyclosporin A treatment for Kawasaki disease refractory to initial and additional Intravenous Immunoglobulin2011

    • Author(s)
      Suzuki H, Terai M, Hamada H, Honda T, Suenaga T, Takeuchi, T, Yoshikawa N, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Iwahashi S, Miyashita R, Onouchi Y, Sasago K, Suzuki Y, Hata A
    • Journal Title

      Pediatr Infect Dis J

      Volume: 30 Pages: 871-876

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ITPKC and CASP3 polymorphism and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease2011

    • Author(s)
      Onouchi Y, et al
    • Journal Title

      The Pharmacogenomics journal

      Volume: (in press) Issue: 1 Pages: 1-8

    • DOI

      10.1038/tpj.2011.45

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 川崎病の病因における新たな展望-川崎病はスーパー抗原病?-2011

    • Author(s)
      鈴木啓之
    • Journal Title

      Prog Med

      Volume: 31 Pages: 1688-1691

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 川崎病の本態にせまる-古くて新しい研究から-肝機能障害2011

    • Author(s)
      鈴木啓之
    • Journal Title

      小児科診療

      Volume: 74 Pages: 1133-1136

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 川崎病急性期にステロイド投与を受けた症例の冠動脈障害は発生の分析2010

    • Author(s)
      鈴木啓之、荻野廣太郎、中村好一、上原里程、屋代真弓、柳川 洋
    • Journal Title

      日本小児科学会雑誌

      Volume: 114(5) Pages: 853-857

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of patients with Kawasaki disease and levels of peripheral endothelial progenitor cells and blood monocyte subpopulations2010

    • Author(s)
      Kuroi A, Imanishi T, Suzuki H, Tujioka H, Yoshikawa N, Akasaka T.
    • Journal Title

      Circ J

      Volume: 74(12) Pages: 2720-2725

    • NAID

      10027424760

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Marker of T -cell activation is elevated in refractory Kawasaki disease2010

    • Author(s)
      Suzuki H, Suenaga T, Shibuta S, Takeuchi T, Yoshikawa N
    • Journal Title

      Pediatr Int

      Volume: 52(5) Pages: 785-789

    • NAID

      10028184424

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common variants in CASP3 confer susceptibility to Kawasaki disease2010

    • Author(s)
      Onouchi Y, Ozaki K, Burns JC, Shimizu C, Hamada H, Honda T, Terai M, Honda A, Takeuchi T, Schibuta S, Suenaga T, Suzuki H, Higashi K, Yasukawa K, Suzuki Y, Sasago K, Kemmotsu Y, Takatsuki S, Saji T, Yoshikawa T, Nagai T, Hamamoto K, Kishi F, Ouchi K, Sato Y, Newburger JW, Baker AL, Shulman ST, Rowley AH, Yashiro M, Nakamura Y, Wakui K, Fukushima Y, Fujino A, Tsunoda T, Kawasaki T, Hata A, Nakamura Y, Tanaka T
    • Journal Title

      Hum Mol Genet

      Volume: 19(14) Pages: 2898-2906

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Common variants in CASP3 confer susceptibility to Kawasaki disease.2010

    • Author(s)
      Onouchi Y, et al.
    • Journal Title

      Hum Mol Genet

      Volume: 19 Pages: 2898-2906

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Marker of T-cell activation is elevated in refractory Kawasaki disease.2010

    • Author(s)
      Suzuki H, et al.
    • Journal Title

      Pediatr Int

      Volume: 52 Pages: 785-789

    • NAID

      10028184424

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of patients with Kawasaki disease and levels of peripheral endothelial progenitor cells and blood monocyte subpopulations.2010

    • Author(s)
      Kuroi A, et al.
    • Journal Title

      Circ J

      Volume: 74 Pages: 2720-2725

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 川崎病急性期にステロイド投与を受けた症例の冠動脈障害は発生の分析2010

    • Author(s)
      鈴木啓之, 他
    • Journal Title

      日本小児科学会雑誌

      Volume: 114 Pages: 853-857

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Do multiple superantigens trigger the onset of Kawasaki disease?2012

    • Author(s)
      Suzuki H
    • Organizer
      The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
    • Place of Presentation
      Tokyo
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cyclosporin A treatment for patients with Kawasaki Disease Resistant to IVIG2012

    • Author(s)
      Suzuki H
    • Organizer
      The 10^<th> International Kawasaki Disease Symposium
    • Place of Presentation
      Kyoto(招待講演)
    • Year and Date
      2012-02-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] IVIG 不応例に対するシクロスポリン A の有用性と今後の展望2012

    • Author(s)
      鈴木啓之
    • Organizer
      第32回日本川崎病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Do multiple superantigens trigger the onset of Kawasaki disease?2012

    • Author(s)
      Suzuki H
    • Organizer
      The Asia Pacific Meeting of Vasculitis and ANCA Workshop 2012
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Epidemiological profile of Kawasaki disease in a complete enumeration study from 1999 to 2010 in Wakayama prefecture2012

    • Author(s)
      Kitano N, Suzuki H, Takeuchi T, Suenaga T, Kakimoto N, Shibuta S, Uemura S, Yohikawa N, Takeshita T
    • Organizer
      Japan The 10th International Kawasaki Disease Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of time-clustering in resistance to intravenous immunoglobulin therapy for Kawasaki disease2012

    • Author(s)
      Suenaga T, Suzuki H, Kakimoto N, Takeuchi T, Yohikawa N, Shibuta S
    • Organizer
      The 10th International Kawasaki Disease Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] Cyclosporin A treatment for patients with Kawasaki Disease Resistant to IVIG2012

    • Author(s)
      Suzuki H
    • Organizer
      The 10th International Kawasaki Disease Symposium
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] IVIG不応例に対するシクロスポリンAの有用性と今後の展望2012

    • Author(s)
      鈴木啓之
    • Organizer
      第32回日本川崎病学会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 光干渉断層法(OCT)を用いた川崎病冠動脈病変の評価の試み2012

    • Author(s)
      垣本信幸
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 光干渉断層法(OCT)を用いた川崎病冠動脈病変の評価2012

    • Author(s)
      垣本信幸
    • Organizer
      第32回日本川崎病研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 第17回~第21回川崎病全国調査への和歌山県からの症例報告割合に関する検討2012

    • Author(s)
      北野尚美
    • Organizer
      第32回日本川崎病研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] シクロスポリン A の難治性川崎病治療における現状と今後の展望2011

    • Author(s)
      鈴木啓之
    • Organizer
      第28回関東川崎病研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] シクロスポリンAの難治性川崎病治療における現状と今後の展望2011

    • Author(s)
      鈴木啓之
    • Organizer
      第28回関東川崎病研究会
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] IVIG 不応の川崎病症例に対するシクロスポリン A 療法2011

    • Author(s)
      鈴木啓之
    • Organizer
      第114回日本小児科学会学術集会 国際シンポジウム1 川崎病 IVIG 不応例への治療戦略
    • Place of Presentation
      東京
    • Year and Date
      2011-08-12
    • Related Report
      2012 Final Research Report
  • [Presentation] IVIG不応の川崎病症例に対するシクロスポリンA療法2011

    • Author(s)
      鈴木啓之
    • Organizer
      第114回日本小児科学会学術集会国際シンポジウム1川崎病IVIG不応例への治療戦略
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-08-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2回の IVIG に不応の川崎病症例に対するシクロスポリン A 療法2011

    • Author(s)
      鈴木啓之
    • Organizer
      第47回日本小児循環器学会学術集会特別シンポジウム 「IVIG 不応重症川崎病症例への挑戦 -炎症制御からみた治療 option-」
    • Place of Presentation
      福岡市
    • Year and Date
      2011-07-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 2回のIVIGに不応の川崎病症例に対するシクロスポリンA療法2011

    • Author(s)
      鈴木啓之
    • Organizer
      第47回日本小児循環器学会学術集会特別シンポジウム「IVIG不応重症川崎病症例への挑戦-炎症制御からみた治療option-」
    • Place of Presentation
      福岡市(招待講演)
    • Year and Date
      2011-07-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 特別講演:川崎病の病因における新たな展望 -川崎病はスーパー抗原病 ?2011

    • Author(s)
      鈴木啓之
    • Organizer
      第35回近畿川崎 病研究会
    • Place of Presentation
      大阪市
    • Related Report
      2012 Final Research Report
  • [Presentation] ランチョンセミナー:「川崎病の病因解明の最前線」川崎病は溶連菌毒素を中心とするスーパー抗原病?2010

    • Author(s)
      鈴木啓之
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム「難治性川崎病の治療戦略」~病態、作用機序から見た戦略~IVIGに不応例に対する治療プロトコール ~シクロスポリンA療法~2010

    • Author(s)
      鈴木啓之、寺井勝、浜田洋通、本田隆文、末永智浩、武内崇、渋田昌一、吉川徳茂, 他
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] イブニングセミナー「この症例をどうする?」巨大冠動脈瘤・狭窄性病変を合併し、治療に難渋している1女児例2010

    • Author(s)
      垣本信幸, 渋田昌一、末永智浩、武内崇、鈴木啓之、吉川徳茂
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 川崎病重症度とITPKC遺伝子多型との関連性の分析2010

    • Author(s)
      鐘木啓之、寺井勝、尾内善広, 他
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2000年以降に和歌山県で発症した川崎病の臨床疫学像と悉皆的調査に基づく罹患率2010

    • Author(s)
      北野尚美、鈴木啓之、武内崇、末永智弘、渋田昌一、南孝臣、上村茂、竹下達也
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都市
    • Year and Date
      2010-10-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 川崎病の病因・治療における新たな展望2010

    • Author(s)
      鈴木啓之
    • Organizer
      川崎病フォーラムin千葉
    • Place of Presentation
      千葉市
    • Year and Date
      2010-07-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 難治性川崎病に対するシクロスポリン治療 シンポジウム:2010

    • Author(s)
      鈴木啓之
    • Organizer
      第34回近畿川崎病研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2010-03-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 川崎病重症度と ITPKC 遺伝子多型との関連性の分析2010

    • Author(s)
      鈴木啓之、寺井 勝、尾内善広、浜田洋通、本田隆文、末永智浩、武内 崇、渋田昌一、 吉川徳茂、鈴木洋一、羽田 明
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] IVIG に不応例に対する治療プロトコール~シクロスポリン A 療法~ シンポジウム「難治性川崎病の治療戦略」~病態、作用機序から見た戦略~2010

    • Author(s)
      鈴木啓之、寺井 勝、浜田洋通、本田隆文、末永智浩、武内 崇、渋田昌一、吉川徳茂、尾内善広、鈴木洋一、羽田 明
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report
  • [Presentation] 川崎病は溶連菌毒素を中心とするスーパー抗原病? ランチョンセミナー:「川崎病の病因解明の最前線」2010

    • Author(s)
      鈴木啓之
    • Organizer
      第30回日本川崎病研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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