| Project/Area Number |
22591191
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
|
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| Research Institution | Kyorin University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
YAN Kunimasa 杏林大学, 医学部, 教授 (70255389)
AKIMOTO Yosihiro 杏林大学, 医学部, 准教授 (60184115)
|
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIGAKI Yasuhito 金沢医科大学, 医学部, 准教授 (20232275)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 小児腎 / 泌尿器学 / ユビキチン / ネフローゼ |
|---|
| Research Abstract |
Unbiased transcriptome profiling and functional genomics approaches identified USP40, a family of deubiquitinating enzyme, as being a transcript highly specific for the glomerulus. But its protein characterization and biologic function is not known at all. USP40 may stabilize HINT1 which is known to up-regurate cellular level of cycln-dependent kinase inhibitor p27kip1, by its ubiquitinating activity, thereby influencing the glomerular deveropmental process via modulating cell cycle system of glomerular endotherial cells and podocytes.
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