• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of Ubiquitin specific protease 40 in Glomerulus

Research Project

Project/Area Number 22591191
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionKyorin University

Principal Investigator

NISHIBORI Yukino  杏林大学, 医学部, 助教 (70407021)

Co-Investigator(Kenkyū-buntansha) YAN Kunimasa  杏林大学, 医学部, 教授 (70255389)
AKIMOTO Yosihiro  杏林大学, 医学部, 准教授 (60184115)
Co-Investigator(Renkei-kenkyūsha) ISHIGAKI Yasuhito  金沢医科大学, 医学部, 准教授 (20232275)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小児腎 / 泌尿器学 / ユビキチン / ネフローゼ
Research Abstract

Unbiased transcriptome profiling and functional genomics approaches identified USP40, a family of deubiquitinating enzyme, as being a transcript highly specific for the glomerulus. But its protein characterization and biologic function is not known at all. USP40 may stabilize HINT1 which is known to up-regurate cellular level of cycln-dependent kinase inhibitor p27kip1, by its ubiquitinating activity, thereby influencing the glomerular deveropmental process via modulating cell cycle system of glomerular endotherial cells and podocytes.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011

All Presentation (6 results)

  • [Presentation] (Department o Pediatrics,Anatomy, Pharmacology,Lab Membrane Biochemistry and Biophysics Graduate School of Biostudies, Kyoto University)Role of ubiquitin specific protease 40(USP40) in glomerular development.2012

    • Author(s)
      Takagi H, Nishibori Y, Kiuchi Z, Ito Y, Kudo A, Akimoto Y, Kimura T, Takematsu H, Yan K
    • Organizer
      The 4thEMBO meeting 2012
    • Place of Presentation
      Nice
    • Related Report
      2012 Final Research Report
  • [Presentation] (杏林大・医・小児科・ 薬理学・ 解剖):糸球体の発生に置けるユビキチン特異的プロテアーゼ40(USP40)の役割2012

    • Author(s)
      高木永, 西堀由紀野, 木村徹,宮東昭彦, 楊國昌
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] 糸球体の発生に置けるユビキチン特異的プロテアーゼ40(USP40)の役割2012

    • Author(s)
      高木永
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of ubiquitin specific protease 40(USP40) in glomerular development.2012

    • Author(s)
      Hisashi Takagi
    • Organizer
      The 4th EMBO meeting 2012
    • Place of Presentation
      Nice, France
    • Related Report
      2012 Annual Research Report
  • [Presentation] The role of Ubiquitin Specific Protease 40 in the Glomerular Endotherial Cells2011

    • Author(s)
      高木永
    • Organizer
      アメリカ腎臓病学会
    • Place of Presentation
      アメリカ・フィラデルフィア
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Ubiquitin Specific Protease40.2011

    • Author(s)
      Takagi H
    • Organizer
      American Society of Nephrology Kidney Week 2011
    • Place of Presentation
      Philadelphia
    • Year and Date
      2011-11-09
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi