Role of Ubiquitin specific protease 40 in Glomerulus

• Project/Area Number: 22591191
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Kyorin University
• Principal Investigator: NISHIBORI Yukino 杏林大学, 医学部, 助教 (70407021)
• Co-Investigator(Kenkyū-buntansha): YAN Kunimasa 杏林大学, 医学部, 教授 (70255389) ; AKIMOTO Yosihiro 杏林大学, 医学部, 准教授 (60184115)
• Co-Investigator(Renkei-kenkyūsha): ISHIGAKI Yasuhito 金沢医科大学, 医学部, 准教授 (20232275)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 小児腎 / 泌尿器学 / ユビキチン / ネフローゼ

Research Abstract

Unbiased transcriptome profiling and functional genomics approaches identified USP40, a family of deubiquitinating enzyme, as being a transcript highly specific for the glomerulus. But its protein characterization and biologic function is not known at all. USP40 may stabilize HINT1 which is known to up-regurate cellular level of cycln-dependent kinase inhibitor p27kip1, by its ubiquitinating activity, thereby influencing the glomerular deveropmental process via modulating cell cycle system of glomerular endotherial cells and podocytes.

Research Products

• [Presentation] (Department o Pediatrics,Anatomy, Pharmacology,Lab Membrane Biochemistry and Biophysics Graduate School of Biostudies, Kyoto University)Role of ubiquitin specific protease 40(USP40) in glomerular development. (2012)
  • Author(s): Takagi H, Nishibori Y, Kiuchi Z, Ito Y, Kudo A, Akimoto Y, Kimura T, Takematsu H, Yan K
  • Organizer: The 4thEMBO meeting 2012
  • Place of Presentation: Nice
• [Presentation] (杏林大・医・小児科・ 薬理学・ 解剖):糸球体の発生に置けるユビキチン特異的プロテアーゼ40(USP40)の役割 (2012)
  • Author(s): 高木永, 西堀由紀野, 木村徹,宮東昭彦, 楊國昌
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 東京
• [Presentation] 糸球体の発生に置けるユビキチン特異的プロテアーゼ40（USP40）の役割 (2012)
  • Author(s): 高木永
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 東京
• [Presentation] Role of ubiquitin specific protease 40(USP40) in glomerular development. (2012)
  • Author(s): Hisashi Takagi
  • Organizer: The 4th EMBO meeting 2012
  • Place of Presentation: Nice, France
• [Presentation] The role of Ubiquitin Specific Protease 40 in the Glomerular Endotherial Cells (2011)
  • Author(s): 高木永
  • Organizer: アメリカ腎臓病学会
  • Place of Presentation: アメリカ・フィラデルフィア
  • Year and Date: 2011-11-10
• [Presentation] Role of Ubiquitin Specific Protease40. (2011)
  • Author(s): Takagi H
  • Organizer: American Society of Nephrology Kidney Week 2011
  • Place of Presentation: Philadelphia
  • Year and Date: 2011-11-09