| Project/Area Number |
22591194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 起立性調節障害 / 起立直後性低血圧 / 脳血流 / 周波数解析 / 自律神経機能 / 脳血流低下型 / Hyper response型 / 体位性頻脈症候群 / 遷延性起立性低血圧 / Finometer / 近赤外分光計 / 酸素化ヘモグロピン / 日本小児心身医学会小児起立性調節障ガイドライン |
|---|
| Research Abstract |
Orthostatic dysregulation has been reported to show four different subtypes of cardiovascular response to standing. We found two additional subsets, ie, the hyper-response type and the hypo-perfusion type, using a non-invasive beat-to-beat blood pressure measurement and a near-infrared spectroscopy. Among 478 children the percentage of the six subtypes is as follows; instantaneous orthostatic hypotension (22.8%), postural tachycardia syndrome (20.7%), delayed orthostatic hypotension (5.0%), neurally-mediated syncope (1.0%), hyper-response type (9.4%), hypo-perfusion type (5.6%), thus fifteen percent of children with OD showed new subtypes. POTS showed marked orthostatic decrease in vagal modulation of the heart determined by power spectral analysis. Head-up tilt training indicated improvement of orthostatic tachycardia and orthostatic tolerance, suggesting a new useful treatment of POTS.
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