Novel biomarkers for childhood idiopathic nephrotic syndrome

• Project/Area Number: 22591196
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatrics
• Research Institution: National Research Institute for Child Health and Development
• Principal Investigator: ITO Shuichi 独立行政法人国立成育医療研究センター, 器官病態系内科部, 腎臓・リウマチ・膠原病科医長 (20336572)
• Co-Investigator(Kenkyū-buntansha): IMAGOME Kenichi (独)国立成育医療研究センター, 母児感染研究部感染防御研究室, 室長 (70304780) ; ABE Jun (独)国立成育医療研究センター, 免疫アレルギー研究部免疫療法研究室, 室長 (40281688) ; 今留 謙一 独立行政法人国立成育医療研究センター, その他部局等, その他 (70392488)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ネフローゼ症候群 / 小児 / リンパ球 / CD40 / CD40 ligand / バイオマーカー / CD40ligand / 小児特発性ネフローゼ症候群 / 共刺激分子 / 可溶性CD30

Research Abstract

Idiopathic nephrotic syndrome is one of the commonest kidney diseases in children. However, its etiology is not elucidated yet. We have evaluated the expression of co-stimulatory molecules on T and B lymphocytes （CD26, CD28、CD80/CD86、CTLA-4、CD69、CD26）by flow cytometry in 11 children with idiopathic nephrotic syndrome. In the result, CD40 ligand expressed on CD4 positive T lymphocyte and CD40 molecule expressed on CD19 positive B lymphocyte are significantly increased at primary onset comparing to at remission and in control children. In addition, western blot analysis revealed that phosphorylated-junk (p-junk), which is in downstream of CD40 signal, is only expressed in patients in active nephorotic phase. These findings suggest that T and B lymphocytes through CD40 and CD40 ligand could play some important role in pathogenesis of nephrotic syndrome. In addition, serum level of soluble CD30 is also significantly increased at primary onset comparing to at remission and in control children. CD30 is also expressed on activated T lymphocyte. Although further investigation is necessary, this finding also suggests mutual activation between T and B lymphocytes. CD40, CD40 ligand and soluble CD30 may be a good candidate of biomarker of nephritic syndrome.

Research Products

• [Journal Article] Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome. (2013)
  • Author(s): Ito S, Kemei K, Ogura M, Udagawa T, Fujinaga S, Saito M, Sako M, Iijima K
  • Journal Title: Pediatr Nephrol Volume: 28 Issue: 2 Pages: 257-64
  • DOI: 10.1007/s00467-012-2319-1
  • Peer Reviewed
• [Journal Article] Atyoical Pneumocystis jiroveci pneumonia with multiple nodular granulomas after rituximab for refractory nephrotic syndrome. Pediatr (2013)
  • Author(s): Sato M, Ito S, Ogura M, Kamei K, Miyairi I, Miyata I, Higuchi M, Matsuoka K
  • Journal Title: Nephrol Volume: 28 Pages: 145-1491
  • Peer Reviewed
• [Journal Article] Atyipical Pneumocystis jiroveci pneumonia with multiple nodular granulomas after rituximab for refractory nephrotic syndrome (2013)
  • Author(s): Sato M, Ito S, Ogura M, Kamei K, Miyairi I, Miyata I, Higuchi M, Matsuoka K
  • Journal Title: Pediatr Nephrol Volume: 28 Pages: 145-149
  • Peer Reviewed
• [Journal Article] Disease Course in Childhood Steroid Sensitive Nephrotic Syndrome Is it Changeable. (2012)
  • Author(s): Ito S
  • Journal Title: Ind J pediatr Volume: 49 Pages: 868-9
  • Peer Reviewed
• [Journal Article] Focal segmental glomerulosclerosis in patients with complete deletion of one WT1 allele. (2012)
  • Author(s): Iijima K, Someya T, Ito S, Nozu K, Nakanishi K, Matsuoka K, Ohashi H, Nagata M, Kamei K, Sasaki S
  • Journal Title: Pediatrics Volume: 129 Issue: 6 Pages: e1621-e1625
  • DOI: 10.1542/peds.2011-1323
  • Peer Reviewed
• [Journal Article] for the Japanese Study Group of Renal Disease in Children. Two-Year Follow-Up of a Prospective Clinical Trial of Cyclosporine for Frequently Relapsing Nephrotic Syndrome in Children. (2012)
  • Author(s): Ishikura K, Yoshikawa N, Nakazato H, Sasaki S, Iijima K, Nakanishi K, Matsuyama T, Ito S, Yata N, Ando T, Honda M
  • Journal Title: Clin J Am Soc Nephrol Volume: 7 Issue: 10 Pages: 1576-1583
  • DOI: 10.2215/cjn.00110112
  • Peer Reviewed
• [Journal Article] Pediaiatric liver-kidney transplantation for hepatorenal fibrocystic disease from a living donor (2012)
  • Author(s): Sakamoto S, Kasahara M, Fukuda A, Tanaka H, Kakiuchi T, Karaki C, Kanazawa H, Kamei K, Ito S, Nakazawa A
  • Journal Title: Pediatr Transplantation Volume: 16 Pages: 99-102
  • Peer Reviewed
• [Journal Article] Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and 2. (*contributed equally to this work) (2012)
  • Author(s): Imadome K*, Yang X*, Wada T*, Nishida N, Mukai T, Fujiwara M, Kawashima H, Kato F, Fujiwara S, Yachie A, Zhao X, Miyawaki T, Kanegane H
  • Journal Title: Herpesviridae Volume: 10 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Sequential monitoring of plasma EBV-DNA level in a patient with EBV-positive Hodgkin lymphoma (2012)
  • Author(s): Uchida E, Honma R, Igarashi A, Kurata M, Imadome K, Omoto E, Miura O, Arai A
  • Journal Title: Rinsho Ketsueki Volume: 53 Pages: 87-91
  • NAID: 10030830029
  • Peer Reviewed
• [Journal Article] Recurrence of chronic active epstein-barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation (2012)
  • Author(s): Arai A, Imadome K, Wang L, Wu N, Kurosu T, Wake A, Yamamoto H, Ota Y, Harigai M, Fujiwara S, Miura O
  • Journal Title: Intern Med Volume: 51 Pages: 777-782
  • NAID: 130002061847
  • Peer Reviewed
• [Journal Article] Maintenance therapy with MMF after rituximab in pediatric patients with steroid-dependent nephrotic syndrome. (2011)
  • Author(s): Ito S, Kamei K, Ogura M, SatoM, Fujimaru T, Ishikawa T, Udagawa T, Iijima K
  • Journal Title: Pediatr Nephrol Volume: 26 Pages: 1823-1828
  • Peer Reviewed
• [Journal Article] Cyclophosphamide followed by Mizoribine as maintenance therapy against refractory steroid dependent nephrotic syndrome. (2011)
  • Author(s): Ito S, Ikeda H, harada T, Kamei K, Takahashi E
  • Journal Title: Pediatr Nephrol Volume: 26 Pages: 1921-2
  • Peer Reviewed
• [Journal Article] Long-TermResults of a Randomized Controlled Trial in Childhood IgA Nephropathy (2011)
  • Author(s): Kamei K, Nakanishi K, Ito S, Saito M, Sako M, Ishikura K, Hataya H, Honda M, Iijima K, Yoshikawa N; for the Japanese Pediatric IgA Nephropathy Treatment Study Group
  • Journal Title: Clin J Am Soc Nephrol Volume: 6 Pages: 130-137
  • Peer Reviewed
• [Journal Article] Maintenance therapy with MMF after rituximab in pediatric patients with steroid-dependent nephrotic syndrome (2011)
  • Author(s): Ito S, Kamei K, Ogura M, Sato M, Fujimaru T, Ishikawa T, Udagawa T, Iijima K
  • Journal Title: Pediatr Nephrol Volume: 26 Pages: 1823-1828
  • Peer Reviewed
• [Journal Article] Preoperative dialysis for liver transplantation of methylmalonic acidemia (2011)
  • Author(s): Kamei K, Ito S, Shigeta T, Sakamoto S, Fukuda A, Horikawa R, Saito O, Muguruma T, Nakagawa S, Iijima K, Kasahara M
  • Journal Title: Ther Apher Dial Volume: 15 Pages: 488-492
  • Peer Reviewed
• [Journal Article] Superior mesenteric artery syndrome : risk factor for duodenal involvement in Henoch-Schonlein purpura (2011)
  • Author(s): Harada T, Kaneko T, Ito S, Hataya H, Nariai A, Mori M, Yokota S
  • Journal Title: Pediatr Int Volume: 53 Pages: 630-633
  • Peer Reviewed
• [Journal Article] GI involvement of sigmoid mucosal erosion in a 13-year-old girl with microscopic polyangiitis (2011)
  • Author(s): Harada T, Ito S, Sasaki T, Kunisaki R, Shiojima H, Ogawa M, Yokota S
  • Journal Title: Gastrointest Endosc Volume: 74 Pages: 937-939
  • Peer Reviewed
• [Journal Article] gender, and body length effects on reference serum creatinine levels determined by an enzymatic method in Japanese children : a multicenter study (2011)
  • Author(s): Uemura O, Honda M, Matsuyama T, Ishikura K, Hataya H, Yata N, Nagai T, Ikezumi Y, Fujita N, Ito S, Iijima K, Kitagawa T
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 694-699
  • Peer Reviewed
• [Journal Article] Autoantibodies to villin occur frequently in IPEX, a severe immune dysregulation, syndrome caused by mutation of FOXP3 (2011)
  • Author(s): Kobayashi I, Kubota M, Yamaada M, Tanaka H, Ito S, Sasahara Y, Whitesell L, Ariga T
  • Journal Title: Clinical Immunology Volume: 141 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Identification of FOXP3-negative regulatory T-like CD(4)+CD25(+)CD127 (low)) cells in patients with immune dysregulation. polyendocrinopathy, enteropathy (2011)
  • Author(s): Otsubo K, Kanegane H, Kamachi Y, Kobayashi I, Tsuge I, Imaizumi M, Sasahara Y, Hayakawa A, Nozu K, Iijima K, Ito S, Horikawa R, Nagai Y, Takatsu K, Mori H, Ochs H, Miyawaki T
  • Journal Title: X-linked syndrome Volume: 141 Pages: 111-120
  • Peer Reviewed
• [Journal Article] Cyclophosphamide followed by Mizoribine as maintenance therapy against refractory steroid dependent nephrotic syndrome (2011)
  • Author(s): Ito S, Ikeda H, harada T, Kamei K, Takahashi E
  • Journal Title: Pediatr Nephrol Volume: 26 Pages: 1921-2
  • Peer Reviewed
• [Journal Article] Living-donor liver transplantation using hyper-reduced graft for a neonatal fulminant hepatic failure (2011)
  • Author(s): Sasaki K, Kasahara M, Fukuda A, Kimura T, Shigeta T, Tanaka H, Nakagawa S, Ito S, Nakagawa A
  • Journal Title: Pediatr Int Volume: 53 Pages: 247-248
  • Peer Reviewed
• [Journal Article] Successful treatment with rituximab and donor lymphocyte infusions for fulminant EBV-associated lymphoproliferative disease that developed 14 years after unrelated BMT (2011)
  • Author(s): Kawaguchi T, Tsukamoto S, Ohwada C, Takeuchi M, Muto T, Tanaka S, Sakai S, Takeda Y, Abe D, Sakaida E, Shimizu N, Yokote K, Iseki T, Imadome K, Nakaseko C
  • Journal Title: Bone Marrow Transplantation Volume: 31 Pages: 1-3
  • Peer Reviewed
• [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood (2011)
  • Author(s): Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome K, Abe Y, Akashi K, Hara T
  • Journal Title: J Clin.Virol. Volume: 51 Pages: 31-37
  • Peer Reviewed
• [Journal Article] Clinical features of adult-onset chronic active Epstein-Barr virus infection : a retrospective analysis (2011)
  • Author(s): Arai A, Imadome K, Watanabe Y, Yoshimori M, Koyama T, Kawaguchi T, Nakaseko C, Fujiwara S, Miura O
  • Journal Title: Int J Hematol Volume: 93 Pages: 602-609
  • NAID: 10029535036
  • Peer Reviewed
• [Journal Article] Epstein-Barr Virus Induces 1 Erosive Arthritis in Humanized Mice (2011)
  • Author(s): Kuwana Y, Takei M, Yajima M, Imadome K, Inomata K, Shiozaki M, Ikumi N, Nozaki N, Shiraiwa H, Kitamura N, Takeuchi J, Sawada S, Yamamoto N, Shimizu N, Ito M, Fujiwara S
  • Journal Title: PLoS One Volume: 6 Pages: 26630-26634
  • Peer Reviewed
• [Journal Article] Novel Mouse Xenograft Models Reveal a Critical Role of CD4+ T Cells in the Proliferation of EBV-Infected T and NK Cells (¶Corresponding author) (2011)
  • Author(s): Imadome K¶, Yajima M, Arai A, Nakazawa A, Kawano F, Ichikawa S, Shimizu N, Yamamoto N, Morio T, Ohga S, Nakamura H, Ito M, Miura O, Komano J, Fujiwara S
  • Journal Title: PLoS Pathogens Volume: 7 Pages: 1002326-1002340
  • Peer Reviewed
• [Journal Article] Increased production of vascular endothelial growth factor-D and lymphangiogenesis in acute Kawasaki disease (2011)
  • Author(s): Ebata R, Abe J, Yasukawa K, Hamada H, Higashi K, Suwazono Y, Saito H, Terai M, Kohno Y
  • Journal Title: Circulation J Volume: 75 Pages: 1455-1462
  • NAID: 10028149134
  • Peer Reviewed
• [Journal Article] 小児期発症難治性ネフローゼに対するリツキシマブ治療の可能性 (2011)
  • Author(s): 伊藤秀一
  • Journal Title: 日本小児腎臓病学会雑誌 Volume: 24 Pages: 156-157
• [Journal Article] 難治性ネフローゼ症候群におけるリツキシマブの恩恵骨合併症の見地から (2011)
  • Author(s): 小椋雅夫, 亀井宏一, 堤晶子, 野田俊輔, 佐藤舞, 藤丸拓也, 石川智朗, 宇田川智宏, 伊藤秀一
  • Journal Title: 日本小児腎臓病学会雑誌 Volume: 24 Pages: 34-35
  • Peer Reviewed
• [Journal Article] ガイドラインでみる小児CKDの診療 (2011)
  • Author(s): 伊藤秀一
  • Journal Title: 日本医事新報 Volume: 4574(解説) Pages: 80-86
• [Journal Article] Clonal origin of Epstein-Barr virus(EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood (2011)
  • Author(s): Ohga S, Ishimura M, Yoshimoto G, Miyamoto T, Takada H, Tanaka T, Ohshima K, Ogawa Y, Imadome K, Abe Y, Akashi K, Hara T
  • Journal Title: J Clin.Virol Volume: 51 Pages: 31-7
  • Peer Reviewed
• [Journal Article] critical care nephrology.小児集中治療病態とAKI. (2011)
  • Author(s): 伊藤秀一
  • Journal Title: 腎と透析 Volume: 70 Pages: 373-377
  • Peer Reviewed
• [Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. (2010)
  • Author(s): Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N. Yokota S
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 2530-2537
  • Peer Reviewed
• [Journal Article] Long-term remission of nephritic syndrome with etanercept for concomitant juvenile idiopathic arthritis. (2010)
  • Author(s): Ito S, Tsutsumi A, Harada T, Inaba A, Fujinaga S, Kamei K
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 2175-2177
  • Peer Reviewed
• [Journal Article] Single infusion of rituxibmab for persistent steroid-dependent minimal-charge nephritic syndrome after long-term cyclosporine. (2010)
  • Author(s): Fujinaga S, Hirano D, Nishizaki N, Kamei K, Ito S, Ohtomo Y, Shimizu T, Kaneko K
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 539-544
  • Peer Reviewed
• [Journal Article] Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis (2010)
  • Author(s): Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, Mori M, Inayama Y, Yan K, Kobayashi N, Yokota S.
  • Journal Title: Nephrol Dial Transplant Volume: 25 Pages: 2530-2537
  • Peer Reviewed
• [Journal Article] Extended-specdtrum beta-lactamase-producing bacteria and vesicoureteral reflux in children (2010)
  • Author(s): Ito S, Machida H, Harada T, Teranishi J, Aihara Y, Yokota S.
  • Journal Title: Pediatr Int. Volume: 52 Pages: 134-137
  • Peer Reviewed
• [Journal Article] Severe Alport syndrome in a young woman caused by a t(X1)(q22.3;p36.32)balaneed translocation. (2010)
  • Author(s): Iijima K, Nozu K, Nakayama M, Ito_S, Matsuoka K, Ogata T, Kaito H, Nakanishi K, Matsuo M
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 2165-2170
  • Peer Reviewed
• [Journal Article] HNF1B alterations associated with congenital anomalies of the kidney and urinary tract. (2010)
  • Author(s): Nakayama M, Nozu K, Goto Y, Kamei K, Ito S, Sato H, Emi M, Nakanishi K, Tsuchiya S, Iijima K.
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 1073-1079
  • Peer Reviewed
• [Journal Article] Long-term remission of nephritic syndrome with etanercept for concomitant juvenile idiopathic arthritis (2010)
  • Author(s): Ito S, Tsutsumi A, Harada T, Inaba A, Fujinaga S, Kamei K
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 2175-2177
  • Peer Reviewed
• [Journal Article] Primary Sjogren syndrome that developed after lgA nepjropathy. (2010)
  • Author(s): Ito S, Kamei K, Ikoma M
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 1579-1580
  • Peer Reviewed
• [Journal Article] Critical illness polyneuropathy after septic peritonitis in a boy with nephritic syndrome. (2010)
  • Author(s): Kikuchi E, Kubota M, Kamei K, Ito S.
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 1771-1772
  • Peer Reviewed
• [Journal Article] Single infusion of rituxibmab for persistent steroid-dependent minimal-charge nephritic syndrome after long-term cyclosporine (2010)
  • Author(s): Fujinaga S, Hirano D, Nishizaki N, Kamei K, Ito S, Ohtomo Y, Shimizu T, Kaneko K
  • Journal Title: Pediatr Nephrol Volume: 25 Pages: 539-544
  • Peer Reviewed
• [Journal Article] ABO-incompatible renal transplantation in Epstein syndrome. (2010)
  • Author(s): Ogura M, Kikuchi E, Kaito H, Kamei K, Matsuoka K, Tanaka H, Kuroda T, Sekine T, Ito S.
  • Journal Title: Clin Transplant. Volume: Suppl 22 Pages: 31-34
  • Peer Reviewed
• [Journal Article] Autoimmune hemolytic anemia accompanied by reactivation of an Epstein-Barr virus infection with suppressed CTL response to EBV-infected cells (2010)
  • Author(s): Arai A, Imadome K, Yamazaki E, Fujiwara S, Miura O
  • Journal Title: Internal Medicine Volume: 49 Pages: 325-329
  • Peer Reviewed
• [Journal Article] Epstein-Barr virus infection after pediatric living-related liver Transplantation-management and risk factors (2010)
  • Author(s): Shigeta T, Imadome K, Sakamoto S, Fukuda A, Kakiuchi T, Matsuno N, Tanaka H, Nakazawa A, Kasahara M.
  • Journal Title: Transplant Proc Volume: 42 Pages: 4178-4180
  • Peer Reviewed
• [Journal Article] 当センターにおける急性血液浄化療法の特色と問題点 (2010)
  • Author(s): 小椋雅夫、亀井宏一、宇田川智宏、堤晶子、野田俊輔、伊藤秀一
  • Journal Title: 日本小児腎不全学会雑誌 Volume: 30 Pages: 309-310
  • NAID: 10027698132
• [Journal Article] 当院における小児劇症肝不全24症例に対する人工肝補助の経験 (2010)
  • Author(s): 堤晶子、小椋雅夫、宇田川智宏、野田俊輔、亀井宏一、唐木千晶、中川聡、福田晃也、笠原群生、中川温子、伊藤秀一
  • Journal Title: 日本小児腎不全学会雑誌 Volume: 30 Pages: 304-306
  • NAID: 10027698122
• [Journal Article] 血液透析を受ける子供と家族への支援乳幼児期の成長発達に合わせた環境墳への配慮 (2010)
  • Author(s): 緒方志穂、林和美、宮本圭奈美、村山由里子、玉城久美子、西海真理、伊藤秀一、伊藤龍子
  • Journal Title: 日本小児腎不全学会雑誌 Volume: 30 Pages: 237-238
• [Journal Article] 高血圧で発症した高安動脈炎の3小児例 (2010)
  • Author(s): 貝藤裕史、亀井宏一、小椋雅夫、菊池絵梨子、星野英紀、中川聡、松岡健太郎、阿部淳、伊藤秀一
  • Journal Title: 小児高血圧研究会誌 Volume: 7 Pages: 49-55
• [Journal Article] マイコプラズマ肺炎およびフェノバルビタール投与後に発症した小児Stevens-Johnson症候群の1例 (2010)
  • Author(s): 松倉節子、國見裕子、井上雄介、松木美和、蒲原毅、稲葉彩、伊藤秀一、佐々木毅、相原雄幸、相原道子、池澤善郎
  • Journal Title: 皮膚科の臨床 Volume: 52 Pages: 963-967
• [Journal Article] 先天性代謝異常症による高アンモニア血症に対する急性血液浄化療法 (2010)
  • Author(s): 篠原真史、六車崇、中川聡、亀井宏一、伊藤秀一
  • Journal Title: ICUとCCU Volume: 34 Pages: 547-554
• [Journal Article] ケースから診るCKD診療法(vol.14)(完)小児CKD 学校検尿では発見できなかった先天性腎疾患の症例 (2010)
  • Author(s): 伊藤秀一
  • Journal Title: 日本医事新報 Volume: 4500 Pages: 54-57
• [Journal Article] 必携 小児の薬の使い方IgA腎症 (2010)
  • Author(s): 伊藤秀一
  • Journal Title: 小児内科 Volume: 42 増刊号 Pages: 605-609
• [Journal Article] 腎・泌尿器疾患へのインフォームド・コンセントと治療戦略 ステロイド依存性頻回再発型ネフローゼ症候群(小児) (2010)
  • Author(s): 伊藤秀一
  • Journal Title: 腎と透析 Volume: 69 Pages: 785-589
• [Presentation] 分子標的療法がもたらす腎臓疾患治療の未来 (2012)
  • Author(s): 伊藤秀一
  • Organizer: 第47回日本小児腎臓病学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-30
• [Presentation] 我が国の小児急性血液浄化療法の実態調査 (2011)
  • Author(s): 伊藤秀一, 佐古まゆみ, 斎藤真梨, 佐藤舞, 藤丸拓也, 小椋雅夫, 亀井宏一
  • Organizer: 第33回日本小児腎不全学会学術集会
  • Place of Presentation: 焼津
  • Year and Date: 2011-10-21
• [Presentation] 小児期発症難治性ネフローゼに対するリツキシマブ治療の可能性 (2011)
  • Author(s): 伊藤秀一
  • Organizer: 第25回九州ネフロロジー研究会
  • Place of Presentation: 柳川
  • Year and Date: 2011-07-30
• [Presentation] Treatment for Refractory Nephrotic Syndrome;Other Immunosuppressive Drugs. (2011)
  • Author(s): Ito S
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-02
• [Presentation] National survey of rituximab treatment for childhood idiopathic nephritic syndrome. (2011)
  • Author(s): Ito S, Kamei K, Udagawa T, Ogura M, Fujimaru T, Ishikawa T, Sato M, Fujinaga S, Iijima K
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: 福岡
  • Year and Date: 2011-06-02
• [Presentation] Treatment for Refractory Nephrotic Syndrome ; Other Immunosuppressive Drugs (2011)
  • Author(s): Ito S
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-06-02
• [Presentation] National survey of rituximab treatment for childhood idiopathic nephritic syndrome (2011)
  • Author(s): Ito S, Kamei K, Udagawa T, Ogura M, Fujimaru T, Ishikawa T, Sato M, Fujinaga S, Iijima K
  • Organizer: The 11th Asian Congress of Pediatric Nephrology
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 2011-06-02
• [Presentation] Efficacy of Maintenance Therapy with Mycophenolate Mofetil after Rituximab for Steroid-Dependent Nephrotic Syndrome. (2011)
  • Author(s): Ito S, Udagawa T, Ogura M, Mayumi S, Kamei K, Iijima K
  • Organizer: Pediatric Academic Societies and Asian Sodiety for Pediatric Reserch Joint Meeting,
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-02
• [Presentation] Efficacy of Maintenance Therapy with Mycophenolate Mofetil after Rituximab for Steroid-Dependent Nephrotic Syndrome (2011)
  • Author(s): Ito S, Udagawa T, Ogura M, Mayumi S, Kamei K, Iijima K
  • Organizer: Pediatric Academic Societies and Asian Sodiety for Pediatric Research Joint Meeting
  • Place of Presentation: Denver, USA
  • Year and Date: 2011-05-02
• [Presentation] ネフローゼ症候群におけるT細胞、B細胞間の共刺激分子の発現と病態との関連性について (2010)
  • Author(s): 伊藤秀一、堤 晶子、野田俊輔、宇田川智宏 小椋雅夫、亀井宏一
  • Organizer: 第45回小児腎臓病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-02
• [Presentation] ステロイド依存性ネフローゼ症候群に対するリツキシマブ単回投与後のミコフェノール酸モフェチルによる維持療法の有効性 (2010)
  • Author(s): 伊藤秀一、堤晶子、野田俊輔、宇田川智宏、小椋雅夫、佐古まゆみ、亀井宏一、飯島一誠
  • Organizer: 第45回小児腎臓病学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-02
• [Presentation] Rapid deterioration of renal function due to thrombotic microangiopathy in a boy with system lupus erythematosus and antiphosphospholipid syndrome (2010)
  • Author(s): Noda S, Kamei K, Tsutsumi A, Udagawa T, Ogura M, Nakagawa S, Matsuoka K, Ito S
  • Organizer: Korea-Japan : The 8th Pediatric Nephrology Seminar
  • Place of Presentation: Busan, Korea
  • Year and Date: 2010-05-29
• [Presentation] National survey of rituximab treatment for childhood idiopathic nehprotic syndrome. (2010)
  • Author(s): Ito S, Kamei K, Ogura M, Udagawa T, Tsutsumi T, Noda S, Fujinaga S, Iijima K.
  • Organizer: International Pediatric Nephrology Association(IPNA): 15th Congress of IPNA 2010
  • Place of Presentation: New York, US
• [Presentation] HUS up to date
  • Author(s): 伊藤秀一
  • Organizer: 第34回日本小児腎不全学会学術集会
  • Place of Presentation: 兵庫
  • Invited
• [Presentation] Nationwide Japanese Survey of Continuous Renal Replacement Therapy for Acute Kidney Injury in Children
  • Author(s): Ito S, Sato M, Ogura M, Kamei K, Sako M
  • Organizer: ASN meeting
  • Place of Presentation: San Diego
• [Book] こどもの腎炎・ネフローゼ (2012)
  • Author(s): 伊藤秀一
  • Total Pages: 202
  • Publisher: メディカルトリビューン
• [Book] こどもの腎炎・ネフローゼ (2012)
  • Author(s): 伊藤秀一、五十嵐 隆
  • Total Pages: 202
  • Publisher: メディカルトリビューン
• [Book] 新 腎不全・透析患者指導ガイド (2012)
  • Author(s): 伊藤秀一、湯村和子，高橋公太，濱田千江子
  • Total Pages: 161
  • Publisher: 日本医事新報社
• [Book] 小児科臨床ピクシス22 小児のネフローゼと腎炎 (2010)
  • Author(s): 伊藤秀一
  • Total Pages: 222
  • Publisher: 中山書店