| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To prevent periventricular leukomalacia (PVL), which is the major cause of the cerebral palsy in the preterm babies, we analyzed the effects of magnesium sulfate and hypothermia on the brain damage using in vivo/in vitro animal model. Magnesium sulfate significantly prevented the brain damage in vivo, and the hypothermia attenuated the apoptosis of the oligodendrocyte-precursor cells (OPC) through temporally preventing the proliferation of OPC.
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