Strategy for hypoxic-ischemic encephalopathy in newborn infants to reduce oxygen free radicals by adjusting hydrogen and oxygen
Project/Area Number |
22591201
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Embryonic/Neonatal medicine
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Research Institution | Kagawa University |
Principal Investigator |
KUSAKA Takashi 香川大学, 医学部附属病院, 講師 (50274288)
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Co-Investigator(Kenkyū-buntansha) |
UENO Masaki 香川大学, 医学部, 準教授 (30322267)
MIKI Takanori 香川大学, 医学部, 準教授 (30274294)
YASUDA Saneyuki 香川大学, 医学部附属病院, 助教 (00380155)
IWASE Takashi 香川大学, 医学部附属病院, 助教 (30284368)
NISHIDA Tomoko 香川大学, 教育学部, 教授 (00243759)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | 低酸素性虚血性脳症 / 脳波 / 脳血液量 / 動物モデル / 虚血再還流 / 新生仔豚 / 低酸素虚血負荷 / 近赤外光 / 新生児 / 新生児仮死 / 活性酸素スカベンジャー |
Research Abstract |
In these studies, we found that combining the cerebral blood volume (CBV) with amplitude-integrated EEG (aEEG) is a more effective guide to control hypoxic/ischemic (HI) insult in a newborn piglet model than aEEG alone, to produce a consistent degree of survivable neuropathological damage. Next, we found that an early CBV increase and longer low-ampitude EEG after insult indicates severe brain injury. Finally, we revealed that Edaravone (a free radical scavenger) reduced histologic neuronal damage related to HI loading in our piglet HI model.
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Report
(4 results)
Research Products
(99 results)
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[Journal Article] The effect of blood transfusion on cerebral hemodynamics in preterm infants2012
Author(s)
Koyano K, Kusaka T, Nakamura S, Nakamura M, Konishi Y, Miki T, Ueno M, Yasuda S, Okada H, Nishida T, Isobe K, Itoh S.
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Journal Title
The effect of blood transfusion on cerebral hemodynamics in preterm infants
Volume: 現在不明
Issue: 7
Pages: 1459-1467
DOI
Related Report
Peer Reviewed
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[Journal Article] Extrauterine environment influences spontaneous low-frequency oscillations in the preterm brain2012
Author(s)
Kato I, Kusaka T, Nishida T, Koyano K, Nakamura S, Nakamura M, Konishi Y, Kunikata J, Jinnai W, Yasuda S, Okada H, Itoh S, Isobe K
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Journal Title
Related Report
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[Journal Article] Hemodynamic changes in the breast and frontal cortex of mothers during breastfeeding2011
Author(s)
Tanimoto K, Kusaka T, Nishida T, Ogawa K, Kato I, Ijichi S, Mikami J, Sobue I, Isobe, K, Itoh S
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Journal Title
Pediatr Res
Volume: 70
Pages: 400-5
Related Report
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[Journal Article] The expression of CD36 in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.2011
Author(s)
Ueno M, Nakagawa T, Nagai Y, Nishi N, Kusaka T, Kanenishi K, Onodera M, Hosomi N, Huang CL, Yokomise H, Tomimoto H, Sakamoto H.
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Journal Title
Neuropathol Appl Neurobiol
Volume: 37
Pages: 727-37
Related Report
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[Journal Article] Functional lateralization of sensorimotor cortex in infants measured using multi-channel near-infrared spectroscopy2011
Author(s)
Kusaka T, Isobe K, Miki T, Ueno M, Koyano K, Nakamura S, Nakamura M, Konishi Y, Kuboi T, Kato I, Okubo K, Yasuda S, Nishida T, Itoh S
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Journal Title
Pediatr Res
Volume: 69
Pages: 430-5
Related Report
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[Journal Article] The expression of CD36 in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.2011
Author(s)
Ueno M, Nakagawa T, Nagai Y, Nishi N, Kusaka T, Kanenishi K, Onodera M, Hosomi N, Huang C, Yokimise H, Tomimoto H, Sakamoto H.
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Journal Title
Neuropathology and Applied Neurobiology
Volume: 37
Issue: 7
Pages: 727-737
DOI
Related Report
Peer Reviewed
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[Journal Article] Axonal damage in acute cerebral infarction showing ADC reduction2010
Author(s)
Ueno M, Onodera M, Naya T, Toyama Y, Hosomi N, Huang CL, Nishiyama Y, Kusaka T, Miki Y, Kohno M, Tomimoto H, Sakamoto H
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Journal Title
J Neurol
Volume: 257
Pages: 1559-61
Related Report
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[Journal Article] Short-term exposure to ethanol causes a differential response between nerve growth factor and brain-derived neurotrophic factor ligand/receptor systems in the mouse cerebellum2010
Author(s)
Wang ZY, Miki T, Lee KY, Yokoyama T, Kusaka T, Sumitani K, Warita K, Matsumoto Y, Yakura T, Hosomi N, Ameno K, Bedi KS, Takeuchi Y
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Journal Title
Neuroscience
Volume: 165
Pages: 485-9
Related Report
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[Presentation] Cerebral Blood Volume (CBV) Using Near-infrared Time-resolved Spectroscopy (TRS) and AEEG Evaluation after Hypoxic-ischemic Insult in Newborn piglets.2012
Author(s)
Nakamura M, Nakamura S, Koyano K, Jinnai W, Yasuda S, Miki T, Ueno M, KusakaT, Isobe K, Itoh S
Organizer
The 8th Congress of Asian Society for Pediatric Research
Place of Presentation
Seoul, Korea
Year and Date
2012-05-18
Related Report
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[Presentation] Early Changes in Cerebral Blood Volume after Asphyxia Impacts for Neuropathological Prognosis in Newborn Piglets2012
Author(s)
Nakamura S, Jinnai W, Koyano K, UenoM, Miki T, Nakamura M, Yasuda S, Kusaka T, Isobe K, Itoh S.
Organizer
The 8th Congress of Asian Society for Pediatric Research
Place of Presentation
Seoul, Korea
Year and Date
2012-05-18
Related Report
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[Presentation] Cerebral Perfusion Impairments during Asphyxia Impacts for Neuropathological Prognosis in Newborn Piglets.2012
Author(s)
Jinnai W, Nakamura S, Koyano K,Ueno M, Miki T, Nakamura M, Yasuda S, Kusaka T, Isobe K, Itoh S.
Organizer
The 8th Congress of Asian Society for Pediatric Research
Place of Presentation
Seoul, Korea
Year and Date
2012-05-18
Related Report
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[Presentation] Cerebral blood volume is the most effective guide to control for the Hypoxic/Ischemic insult in a newborn piglet model2011
Author(s)
Kusaka T, Nakamura S, Koyano K, Nakamura M, Yasuda S, Okubo K, Isobe K, Itoh S, Ueno M, Miki T
Organizer
BRAIN'11 & BRAINPET'11
Place of Presentation
Barcelona, Spain
Year and Date
2011-05-25
Related Report
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[Presentation] Which Is the Most Effective Guide To Control Hypoxic/Ischemic Insult in a Newborn Piglet Model? Cerebral Electrocortical Activity Versus Cerebral Blood Volume2011
Author(s)
Nakamura S, Koyano K, Ueno M, Miki T, Nakamura M, Ijichi S, Yasuda S, Okubo K, Kusaka T, Isobe K, Itoh S
Organizer
The 7th Congress of Asian Society for Pediatric Research
Place of Presentation
Denver, USA
Year and Date
2011-04-30
Related Report
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[Presentation] Cerebral Blood Volume Evaluation Using Near-Infrared Time Resolved Spectroscopy after Hypoxic Ischemic Insult in Newborn Piglets.2011
Author(s)
Nakamura M, Nakamura S, Koyano K, Matsuoka T, Yasuda S, Okubo K, Kusaka T, Isobe K, Itoh S, Miki T, Ueno M
Organizer
The 7th Congress of Asian Society for Pediatric Research
Place of Presentation
Denver, USA
Year and Date
2011-04-30
Related Report
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[Presentation] Influence of a Free Radical Scavenger on Cerebral Circulation Early after Resuscitation in a Newborn Piglet Hypoxic-Ischemic Model2011
Author(s)
Kusaka T, Nakamura S, Koyano K, UenoM, Miki T, Nakamura M, Yasuda S, Okubo K, Isobe K, Itoh S
Organizer
The 7th Congress of Asian Society for Pediatric Research
Place of Presentation
Denver, USA
Year and Date
2011-04-30
Related Report
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