| Project/Area Number |
22591207
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|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
|---|
| Research Field |
Embryonic/Neonatal medicine
|
|---|
| Research Institution | Showa University |
|---|
Principal Investigator |
OGAWA Tetsuo 昭和大学, 医学部, 講師 (60384210)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIODA Seiji 昭和大学, 医学部, 教授 (80102375)
KAGEYAMA Hruaki 桐生大学, 医療保健学部, 准教授 (00433839)
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|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | DOHaD / 子宮内環境 / 低栄養 / 生活習慣病 / 胎児期低栄養 / DNAマイクロアレイ1 / DNAマイクロアレイ / DNAマイクロアレイ解析 / 胎児肝臓 / 胎児期給餌制限 / 胎児期のアンチエイジング / 絶食 / 胎生期ストレス / DOHAD |
|---|
| Research Abstract |
Prenatal undernutrition has been associated with increased risks of adult diseases. We treated pregnant mice with 50% food restriction, and performed global gene expression and promoter DNA methylation profiling on the fetal livers. We successfully found genes such as trib1 which has been associated with heart diseases, and many genes related to the immune system, and glucocorticoid signaling. These searched genes may be useful to predict nutritional environment during fetal period, and risks of adult diseases due to fetal environments.
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