Treatment strategy for perinatal brain damage by using umbilical cord stem cells.
| Project/Area Number |
22591209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MUGISHIMA Hideo 日本大学, 医学部, 教授 (80183648)
YAMAMOTO Tatuo 日本大学, 医学部, 教授 (40167721)
FUCHIGAMI Tatuo 日本大学, 医学部, 准教授 (60201753)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 臍帯血幹細胞輸血 / 胎盤血輸血 / 新生児仮死 / 超早産児 / 先天性水頭症 / 神経学的後障害 / 低酸素性虚血性脳症 / 臍帯ミルキング / 経学的後障害 / 幹細胞移植 / 再生医療 / 周産期脳障害 |
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| Research Abstract |
Average volume of placental transfusion in premature infants was 17.7ml/kg. Stem cells in this value accounted for about half volume from stored placental whole blood in public umbilical cord blood bank. However, regards placental transfusion in premature infants, there was no statistic difference in the death and/or the neurodevelopmental outcome at the corrected age of 3 years between the control groups and the intervention group. Meanwhile, the clinical research investigation committee approved the trial of treatment of autologous cord blood stem cell for infants with neurodevelopmental abnormalities caused by birth asphyxia or congenital hydrocephalus in 2011. But, we had no asphyxiated infants with 5-min Apgar score less than three and congenital hydrocephalus born in our hospital after the approval. So I could not harvest the umbilical cord blood. It is important to build a framework to collect the placental blood in the clinics.
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Report
(4 results)
Research Products
(28 results)
