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The redox environment surrounding lung epithelia is collapsed in the infants exposed antenatally to placental infection with subsequent bronchopulmonary dysplasia

Research Project

Project/Area Number 22591211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionOsaka Medical College

Principal Investigator

OGIHARA Tohru  大阪医科大学, 医学部, 講師 (00211128)

Co-Investigator(Kenkyū-buntansha) OUE Shinya  大阪医科大学, 医学部, 助教 (40399085)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords新生児慢性肺疾患 / グルタチオン / アスコルビン酸 / レドックス / 酸化還元電位 / 尿酸 / 酸化還元電立
Research Abstract

Although there is little clinical evidence about whether or not lung injury practically occurs in fetuses with chorioamnionitis, this possibly means that some of the infants with BPD had already suffered parenchymal lung injury while in utero. We have previously shown that, in most of moderate/severe BPD infants, the plasma KL-6 level was already increased in the cord blood plasma, especially when the infants were exposed to chorioamnionitis. Therefore, it seems likely that prenatal lung injury associated with chorioamnionitis usually has a priming effect that predisposes fetal lungs to become more susceptible to subsequent toxic agents, rather than lung injury being directly induced by intrauterine infection. Recently, it is gradually known that the redox environment surrounding cells / tissues possibly influence the cellular viability such as growth, differentiation, or apoptosis. We hypothesized that the redox environment of pulmonary epithelial lining fluids may be collapsed when the infants were exposed to placental infections, and may lead to the development of severe BPD because of impaired growth / differentiation of their lungs. We measured the oxidized to reduced ratio of major small-molecular antioxidants in pulmonary epithelial lining fluids such as ascorbic acid, glutathione, and uric acid in the preterm infants born before 28 week gestation. As a result, both of the ratios of dehydroascorbic acid / reduced ascorbic acid and glutathione disulfide / reduced glutathione were increased in the infants with placental infections subsequently developed BPD. Especially, dehydroascorbic acid / reduced ascorbic acid ratio was in good correlation with the values of IgM and KL-6 in cord blood plasma. Therefore, it was clearly shown that the redox environment of pulmonary epithelial lining fluids was dysregulated in the infants with placental infection.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (3 results) (of which Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants.2012

    • Author(s)
      Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H.
    • Journal Title

      Pediatr Res.

      Volume: 71 Pages: 267-73

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antenatal exposure to Ureaplasma species exacerbates bronchopulmonary dysplasia synergistically with subsequent prolonged mechanical ventilation in preterm infants2012

    • Author(s)
      Inatomi T, Oue S, Ogihara T, Hira S, Hasegawa M, Yamaoka S, Yasui M, Tamai H
    • Journal Title

      Pediatric Research

      Volume: 71 Issue: 3 Pages: 267-273

    • DOI

      10.1038/pr.2011.47

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Meconium aspiration2011

    • Author(s)
      Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H.
    • Journal Title

      Neonatology.

      Volume: 99 Pages: 272-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] カルボニル化蛋白2010

    • Author(s)
      荻原享
    • Journal Title

      日本臨床68広範囲血液・尿化学検査

      Pages: 843-8

    • Related Report
      2012 Final Research Report
  • [Journal Article] Meconium Aspiration Delays Normal Decline of Pulmonary Vascular Resistance Shortly after Birth through Lung Parenchymal Injury.2010

    • Author(s)
      Ban R, Ogihara T, Mori Y, Oue S, Ogawa S, Tamai H
    • Journal Title

      Neonatology

      Volume: 99 Pages: 272-279

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neonatal streptococcal toxic shock syndrome caused by Streptococcus dysgalactiae subsp. equisimilis.2010

    • Author(s)
      Yamaoka S, Ogihara T, Yasui M, Hasegawa M, Hira S, Oue S, Ubukata K, Watanabe H, Takahashi T
    • Journal Title

      Pediatr Infect Dis J.

      Volume: 29 Pages: 979-981

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] カルボニル化タンパク2010

    • Author(s)
      荻原享
    • Journal Title

      日本臨床

      Volume: 68 Pages: 843-848

    • Related Report
      2010 Annual Research Report
  • [Presentation] Non-resolving inflammation としての CLD~ 新たな視点から、次世代の予防・治療法を考 える~2013

    • Organizer
      近畿新生児研究会 招待講演
    • Place of Presentation
      大阪
    • Year and Date
      2013-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性疾患としての CLD ー 視点 を変えれば、新たな可能性が?見?えてくる2011

    • Author(s)
      荻原 享
    • Organizer
      日本未熟児新生児学会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Non-resolving inflammationとしてのCLD~新たな視点から、次世代の予防・治療法を考える~

    • Author(s)
      荻原 享
    • Organizer
      近畿新生児研究会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 今〓日の〓小児治療指針 第15 版2012

    • Author(s)
      荻原享新生児慢性肺疾患
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.osaka-med.ac.jp/deps/nicu/shinseiji/aim/index.html

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-11-30   Modified: 2019-07-29  

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