| Project/Area Number |
22591213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Institute for Developmental Research, Aichi Human Service Center |
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Principal Investigator |
NAKANISHI Keiko 愛知県心身障害者コロニー発達障害研究所, 周生期学部, 主任研究員 (50280813)
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| Research Collaborator |
HIGASHI Yujiro 愛知県心身障害者コロニー発達障害研究所, 周産期学部, 部長
OHIRA Atsuhiko 名古屋大学, 小児科, 研究員
SATO Yoshiaki 名古屋大学, 総合周産期母子医療センター・新生児科, 病院助教
ITO Miharu 名古屋大学, 総合周産期母子医療センター・新生児科, 医師
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 新生児低酸素性虚血性脳症 / 臍帯血幹細胞 / 周生期脳障害 / 糖鎖 / 神経細胞死 |
|---|
| Research Abstract |
We investigated the therapeutic effect of umbilical cord blood-derived cells (UCBC) on neonatal hypoxia-ischemia encephalopathy (HIE) model in rats. Mononuclear cells isolated from rat umbilical cord blood were propagated in culture using growth factors and the cells were administered to HIE model of rats. Administration of UCBC decreased the infarct size and improved motor functions. These results indicate that administration of UCBC is a promising therapy for neonatal hypoxia-ischemia.
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