Basic studies on therapeutic utilities ofIL-27 for malignant melanoma, psoriasis and alopecia areata.

• Project/Area Number: 22591220
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Kobe University
• Principal Investigator: NAGAI Hiroshi 神戸大学, 医学部附属病院, 講師 (80335447)
• Co-Investigator(Kenkyū-buntansha): YOSHIMOTO Takayuki 東京医科大学, 医学部, 教授 (80202406)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 悪性黒色腫 / 乾癬 / サイトカイン / IL-27

Research Abstract

We conducted studies on therapeutic effects of interleukin (IL)-27 on malignant melanoma and psoriasis in murine models. We also examined the effects ofIL-27 on chemokine production from human epidermal keratinocytes and demonstrated that IL-27 and IL-17 exerted opposite effects on tumor necrosis factor-alpha-mediated psoriasis relatedchemokine production.

Research Products

• [Journal Article] Interleukin(IL)-17 versus IL-27: Opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes (2012)
  • Author(s): S. Fujiwara, H. Nagai, S. Oniki, T. Yoshimoto, and C. Nishigori
  • Journal Title: Exp. Dermatol Volume: 21 Issue: 1 Pages: 70-72
  • DOI: 10.1111/j.1600-0625.2011.01384.x
  • Peer Reviewed
• [Journal Article] IL-17 versus IL-27 : Opposite effects on TNF-α-induced chemokine production in human keratinocytes (2012)
  • Author(s): Fujiwara S, Nagai H, Oniki S, Yoshimoto T, Nishigori C
  • Journal Title: Experimental Dermatology Volume: 21 Pages: 70-72
  • Peer Reviewed
• [Journal Article] IL-23 gene therapy for mouse bladder tumor cell lines (2011)
  • Author(s): T. Kuramoto, R Fujii, H. Nagai, M.L.Belladonna, T. Yoshimoto, Y. Kohjimoto, T. Inagaki, and I. Hara.
  • Journal Title: BJU int Volume: 108 Issue: 6 Pages: 914-921
  • DOI: 10.1111/j.1464-410x.2010.10025.x
  • Peer Reviewed
• [Journal Article] Antimelanoma immunotherapy: clinical and preclinical applications of IL-12 family members (2010)
  • Author(s): H. Nagai, S. Oniki, S. Fujiwara, T. Yoshimoto, and C. Nishigori
  • Journal Title: Immunotherapy. Volume: 2 Issue: 5 Pages: 697-709
  • DOI: 10.2217/imt.10.46
  • Peer Reviewed
• [Presentation] Interleukin-17 and interleukin-27 exert opposite effects on tumor necrosis factor-alpha -mediated psoriasis related chemokine production in human keratinocytes (2012)
  • Author(s): Susumu Fujiwara, Hiroshi Nagai, Shuntaro Oniki, Takayuki Yoshimoto, and Chikako Nishigori
  • Organizer: 2ndEasetern Asia Dermatology Congress
  • Place of Presentation: Beijing, China
• [Presentation] IL-17 versus IL-27 : opposite effects on TNF-α-induced chemokine production in human keratinocytes (2011)
  • Author(s): Fujiwara S, Nagai H, Oniki S, Yoshimoto T, Nishigori C
  • Organizer: 日本研究皮膚科学会第36回年次学術大会・総会
  • Place of Presentation: 国立京都国際会館(京都府)
  • Year and Date: 2011-12-09
• [Presentation] IL-17 versus IL-27: Opposite effects on tumor necrosis factor-alpha-mediated chemokine production in human keratinocytes (2011)
  • Author(s): Susumu Fujiwara, Hiroshi Nagai, Shuntaro Oniki, Takayuki Yoshimoto, and Chikako Nishigori
  • Organizer: 日本研究皮膚科学会第36回年次学術大会・総会
  • Place of Presentation: 京都
• [Book] 皮膚科臨床アセット 11 (2012)
  • Author(s): 永井 宏
  • Publisher: メラノーマに伴う白斑の病態・診断・鑑別診断
• [Book] 皮膚科臨床アセット (2012)
  • Author(s): 永井 宏
  • Publisher: Sutton 白斑の病態・診断・鑑別診断