Identification of signals involved melanomagenesis and melanoma growth, expecially, UV-induced melanoma formation

• Project/Area Number: 22591221
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Nippon Medical School
• Principal Investigator: FUNASAKA Yoko 日本医科大学, 医学部, 准教授 (30209150)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 悪性黒色腫 / 発癌 / メラニン / 紫外線 / DNA 損傷 / DNA損傷 / シグナル

Research Abstract

Fair skin caucasians with red hair are more susceptible to UV-induced melanoma. We generated melanoma model mouse harboring epidermal melanocytes with different melanin species, then irradiated with UVB or UVA. UVA irradiation did not accelerate melanoma formation, however, UVB did so. Especially, pheomlanin, which is produced more in caucasians. Pheomelanin containing epidermis showed prolonged CPDs after UVB irradiation. DNA repair-deficient mouse also showed early melanoma formation. These results indicate that DNA damages caused by UVB and pheomelanin could be a trigger of melanoma formation.

Research Products

• [Journal Article] Nishigori C: Pharmacogenomics ofmetabotropic glutamate receptor subtype-1 andin vivo malignant melanoma formation. (2010)
  • Author(s): Abdel-Daim, M, Funasaka Y (double first),Komoto M, Nakagawa Y, Yanagita E
  • Journal Title: J Dermatol Volume: 37 Pages: 635-646
  • Peer Reviewed
• [Journal Article] Pharmacogenomics of metabotropic glutamate receptor subtype-1 and in vivo malignant melanoma formation. (2010)
  • Author(s): Abdel-Daim M
  • Journal Title: J Dermatol Volume: 37 Pages: 635-646
  • Peer Reviewed
• [Presentation] 紫外線発癌としての黒色腫-DNA損傷と免疫反応 (2013)
  • Author(s): 船坂陽子
  • Organizer: 第76回日本皮膚科学会東京支部学術大会
  • Place of Presentation: シンポジウム、東京
  • Year and Date: 2013-02-16
• [Presentation] 代謝型グルタミン酸受容体1型(mGluR1)に注目した悪性黒色腫形成および増殖に関わるシグナル伝達の同定第8回加齢皮膚医学研究会 (2012)
  • Author(s): 船坂陽子
  • Organizer: 第5回ロート賞受賞記念講演
  • Place of Presentation: 高知
  • Year and Date: 2012-07-08
• [Presentation] Ultraviolet B, but not ultraviolet A initiates and promotes melanoma formation in metabotropic glutamate receptor 1 transgenic mouse (2011)
  • Author(s): Funasaka Y
  • Organizer: The 36^<th> Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都
  • Year and Date: 2011-12-10
• [Presentation] Ultraviolet B, but not ultraviolet A initiates and promotes melanoma formation in metabotropic glutamate receptor 1 transgenic mouse (2011)
  • Author(s): Funasaka Y
  • Organizer: 21^<st> International Pigment Cell Conference
  • Place of Presentation: Bordeaux France
  • Year and Date: 2011-09-21
• [Presentation] UVAおよびUVBによる発癌,太陽紫外線防御研究委員会 (2011)
  • Author(s): 船坂陽子
  • Organizer: 第21回シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2011-03-11
• [Presentation] Kawana S,Nishigori C.:Ultraviolet B, but not ultraviolet A initiates and promotes melanoma formationin metabotropic glutamate receptor 1transgenic mouse. (2011)
  • Author(s): Funasaka Y, Oyama S, Okazaki S
  • Organizer: The 36th Annual Meeting ofthe Japanese Society for InvestigativeDermatology, Kyoto
  • Place of Presentation: ConcurrentSession
• [Presentation] Nishigori C.:Ultraviolet B, but not ultraviolet A initiates and promotes melanoma formation in metabotropic glutamate receptor 1transgenic mouse (2011)
  • Author(s): Funasaka Y, Oyama S, Okazaki S, Kawana S
  • Organizer: 21^<st> International PigmentCell Conference
  • Place of Presentation: Bordeaux France
• [Presentation] Signals involved in oncogenic activities of metabotropic glutamate receptor 1. (2010)
  • Author(s): Funasaka Y
  • Organizer: 16^<th> Annual Meeting-of European Society for Pigment Cell Research
  • Place of Presentation: Cambridge
  • Year and Date: 2010-09-06
• [Presentation] Nishigori C.:Signals involved in oncogenic activities of metabotropic glutamate receptor 1. (2010)
  • Author(s): Funasaka Y, Abdel-Daim M, Harada T, AibaA, Kawana S
  • Organizer: 16^<th> Annual Meeting of European Society for Pigment Cell Research
  • Place of Presentation: Cambridge
• [Presentation] 代謝型グルタミン酸受容体1型（mGluR1）に注目した悪性黒色腫形成および増殖に関わるシグナル伝達の同定
  • Author(s): 船坂陽子
  • Organizer: 第8回加齢皮膚医学研究会
  • Place of Presentation: 高知
  • Invited
• [Presentation] 遺伝子改変mGluRマウスを用いた紫外線による黒色腫形成機序の解析
  • Author(s): 船坂陽子
  • Organizer: 第13回光老化研究会
  • Place of Presentation: 東京
• [Presentation] 紫外線発癌としての黒色腫―DNA損傷と免疫反応―
  • Author(s): 船坂陽子
  • Organizer: 第76回日本皮膚科学会東京支部学術大会
  • Place of Presentation: 東京