| Project/Area Number |
22591222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Nanako 鳥取大学, 医学部附属病院, 准教授 (10304213)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | 電子顕微鏡 / 皮膚がん / 悪性黒色腫 / ダーモスコピー / 形態観察 / 免疫組織化学染色 / 癌 / 悪性黒色種 / がん |
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| Outline of Final Research Achievements |
On the morphological observation by scanning electron microscope, tumor cell nests of nevi were homogeneously distributed on the surface of basal cell layer in the epidermis. In contrast, those of melanomas were not seen on the surface, but were seen from opening spaces between epidermal cells. On immunohistochemical examination, although tumor cell nests of nevi were recognized adjacent to the basement membrane, there were few melanoma cells in the basal cell layer. Based on these findings, it is most likely that melanoma cells are located on the different place in the basal cell layer compared with nevus. In addition, it has been suggested that melanoma cells proliferate in the intermediate ridge of the epidermis at first, then migrate to transverse ridge and finally invade into the dermis.
The results of our study seem to be useful to distinguish melanoma from nevus.
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