| Project/Area Number |
22591223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
MUTO Masahiko 山口大学, 大学院・医学系研究科, 教授 (40175625)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIMIYA Makoto 山口大学, 大学院・医学系研究科, 准教授 (20314809)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乾癬 / 発症原因遺伝子 / 高次構造 / 原因遺伝子 / 遺伝子ネットワーク / IL-36RN遺伝子 / CCHCR1遺伝子 / HLA遺伝子 / 発症候補遺伝子 / アディポネクチン / HLA-C / CD152 / 脂肪酸結合蛋白 |
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| Research Abstract |
The present study was to investigate the pathophysiological aspects concerning the development of psoriasis (psoriasis vulgaris (N=200), generalized pustular psoriasis(N=10), psoriatic arthritis(N=30) in Japan. We can summarize the results of the present study as follows: first, immunological markers (IL-12B, IL-36RN, TNF-α, and CTLA4) as well as HLA might be involved in the development of psoriasis. Second, genetic defects of the IL-36RN are essential to develop the generalized pustular psoriasis but not psoriasis vulgaris. Moreover these genetic defects of IL-36RN are due to the founder effect of the gene. Third, FABP5 combining linoleic acid is found to be very important in regulating cytokeratin gene K1 of the epidermis , by experiments using FABP5 knockout mice.
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