| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
To develop a prognostic model for predicting the outcome of primary 'cutaneous-type' ATL, prognostic factors in the smoldering-type ATL patients with cutaneous lesions were analyzed. Independent prognostic factors for poor overall survival in multivariate analyses were higher age, high serum LDH, and higher soluble IL-2 receptor levels, while erythroderma and CXCR3 expression on tumor cells were associated with good survival. High serum LDH and higher soluble IL-2 receptor levels were also associated with higher risk for acute crisis or death from ATL. Patients with erythroderma or CXCR3-/T-bet-expressing tumor cells had lower risk for disease progression.
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