Development of novel melanoma therapy targeting SIRT1
Project/Area Number |
22591228
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Dermatology
|
Research Institution | Sapporo Medical University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HORIO Yosiyuki 札幌医科大学, 医学部, 教授 (30181530)
HIDA Tokimasa 札幌医科大学, 医学部, 助教 (90464487)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 分子腫瘍学 / 色素細胞学 / 悪性黒色腫 / メラノーマ / SIRT1 / B16F1メラノーマ細胞 / 細胞移動 / 転移 / lamellipodium / 悪性黒色腫(メラノーマ) / 悪性黒色腫 SIRT1 / B16F1メラノーマ細胞転移 |
Research Abstract |
SIRT1 was localized in the cytoplasm of melanoma cells and the SIRT1 inhibitor nicotinamide suppressed their migration. SIRT1 was detected with F -actin in the protuberance of the cell membrane and accumulated with PIP-3 and AKT. Nicotinamide inhibited the peritoneal invasion and lymph node metastasis of transplanted B16F1 cells in C57BL mice and extended their life span. These results indicate that SIRT1 inhibition may be applicable for the suppression of metastatic melanoma.
|
Report
(4 results)
Research Products
(39 results)
-
[Journal Article] Mechanism of putative neo-antigen formation from N-propionyl-4-S-cysteaminylphenol, a tyrosinase substrate, in melanoma models2012
Author(s)
Ito S, Nishigaki A, Ishii-Osai Y, Ojika M, Wakamatsu K, Yamashita T, Tamura Y, Ito A, Honda H, Nakayama E, Jimbow K
-
Journal Title
Biochemical Pharmacology
Volume: 84
Pages: 646-53
Related Report
-
[Journal Article] T-cell receptor repertoires of tumor-infiltrating lymphocytes after hyperthermia using functionalized magnetite nanoparticles2012
Author(s)
Ito A, Yamaguchi M, Okamoto N, Sanematsu Y,Kawabe Y, Wakamatsu K, Ito S, Honda H, Kobayashi T, Nakayama E, Tamura Y, Okura M, Yamashita T, Jimbow K, Kamihara M
-
Journal Title
Nanomedicine
Volume: (epub ahead of print)
Issue: 6
Pages: 891-902
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] N-propionyl-4-S-cysteaminylphenol induces apoptosis in B16F1 cells and mediates tumor-specific T-cell immune responses in a mouse melanoma model2012
Author(s)
Ishii-Osai Y, Yamashita T, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Nakayama E, Okura M, Jimbow K
-
Journal Title
J Dermatol Sci 67
Pages: 51-60
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Melanoma-targeted chemo-thermo- immuno (CTI) -therapy using N-propionyl-4-S-cysteaminylphenol-magnetite nanoparticles elicits CTL response via heat shock protein-peptide complex release2010
Author(s)
Sato A, Tamura Y, Sato N, Yamashita T, Takada T, Sato M, Osai Y, Okura M, Ono I, Ito A, Honda H, Wakamatsu K, Ito S, Jimbow K
-
Journal Title
Cancer Science 101
Pages: 1939-1946
NAID
Related Report
-
-
-
-
-
-
[Presentation] Conjugation of MagnetiteNanoparticles with Melanogenesis Substrate, NPrCAP Provides Melanoma Targeted, in Situ Peptide Vaccine Immunotherapy through HSP Production by Chemo-Thermotherapy2012
Author(s)
Jimbow K, Tamura Y, Yoneta A, Kamiya T, Ono I, Yamashita T, Ito A, Honda H,Wakamatsu K, Ito S, Nohara S, Nakayama E, Kobayashi T
Organizer
J Biomat Nanobiotech
Related Report
-
-
-
[Presentation] N-Propionyl-4-S-Cysteminylphenol generates reactive oxygen species and mediates apoptosis in pigmented melanoma cells2011
Author(s)
Ishii-Osai Y, Yamashita T, Okura M, Tamura Y, Sato N, Ito A, Honda H, Wakamatsu K, Ito S, Jimbow K
Organizer
International Pigment Cell Conference
Place of Presentation
Bordeaux, France
Related Report
-
[Presentation] Resveratrol ameliorates dystrophic muscle pathogenesis in mdx mouse, a model for Duchenne muscular dystrophy. Gordon Research Coference Muscle Myogenesis2011
Author(s)
Hori Y, Kuno A, Hosoda R, Tanno M, Miura T, Shimamoto K, Horio Y
Organizer
New Horizons for Myogenesis
Place of Presentation
Waterville Valley Resort, Waterville Valley, NH, USA
Related Report
-
-
-
-
-
-
-
-
-
-