| Project/Area Number |
22591230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
SAITO Saburo 東京慈恵会医科大学, 医学部, 准教授 (10186934)
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| Co-Investigator(Kenkyū-buntansha) |
AKIYAMA Nobutake 恵会医科大学, 医学部, 講師 (00338865)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IL-31 / IL-31レセプター / 抗体 / インターロイキン３１ / ノックインマウス / 活性化マクロファージ / 毛根細胞 |
|---|
| Research Abstract |
To analyze the pleiotropic functions of IL-31, specific antibodies to IL-31 receptor A (IL-31R) were established. These antibodies will be useful tools for analysis of localization of the IL-31R-expressing cells and IL-31 function by administration into mice. Furthermore, to investigate the function of IL-31 or the IL-31 receptor, 2 strains of IL-31 or IL-31 receptor (IL-31R) knockout/LacZknockin mice were generated. To produce offspring with a genetic identity for the analysis of the pleiotropic functions of IL-31, the heterozygous mouse will be backcrossed 7 or more times into the C57BL/6J genetic background.
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