Detection and functional analysis of human T lymphotropic virus type 1 infection in the skin dendritic cells.

• Project/Area Number: 22591234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hamamatsu University School of Medicine (2011-2012); University of Occupational and Environmental Health, Japan (2010)
• Principal Investigator: SHIMAUCHI Takatoshi 浜松医科大学, 医学部附属病院, 講師 (90399204)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ウイルス / 腫瘍免疫 / 癌 / ウイルスシナプス / HTLV-1 / 樹状細胞

Research Abstract

The role of the dendritic cells - T-cells virological synapse in Human T lymphotropic virus type 1 infection with implications for the pathogenesis of adult T-cell leukemia / lymphoma

Research Products

• [Journal Article] Combination of skin-directed therapy and oral etoposide for smoldering adult T-cell leukemia/lymphoma with skin involvement (2013)
  • Author(s): awada Y, Shimauchi T, Yamaguchi T, Okura R, Hama-Yamamoto K, Fueki-Yoshioka H, Ohmori S, Yamada S, Yoshizawa M, Hiromasa K, Tajiri M, Kabashima-Kubo R, Yoshioka M, Sugita K, Yoshiki R, Hino R, Kobayashi M, Izu K, Nakamura M, Tokura Y
  • Journal Title: Leuk Lymphoma Volume: 54(3) Pages: 520-7
• [Journal Article] Guidelines for the management of cutaneous lymphomas (2011): A consensus statement by the Japanese Skin Cancer Society-Lymphoma Study Group. (2013)
  • Author(s): Sugaya M, Hamada T, Kawai K, Yonekura K, Ohtsuka M, Shimauchi T, Tokura Y, Nozaki K, Izutsu K, Suzuki R, Setoyama M, Nagatani T, Koga H, Tani M, Iwatsuki K
  • Journal Title: J Dermatol Volume: 40(1) Pages: 2-14
• [Journal Article] Combination of skin-directed therapy and oral etoposide for smoldering adult T-cell leukemia/lymphoma with skin involvement (2013)
  • Author(s): Sawada Y
  • Journal Title: Leuk Lymphoma Volume: 54 Issue: 3 Pages: 520-527
  • DOI: 10.3109/10428194.2012.715351
  • Peer Reviewed
• [Journal Article] Guideline for the management of cutaneous lymphoma (2011): a consensus statement by the Japanese Skin Cancer Society - Lymphoma Study Group (2013)
  • Author(s): Sugaya M
  • Journal Title: J Dermatol Volume: 40 Issue: 1 Pages: 2-14
  • DOI: 10.1111/j.1346-8138.2012.01639.x
  • Peer Reviewed
• [Journal Article] HTLV-1 Associated Infective Dermatitis: Updates on the Pathogenesis (2012)
  • Author(s): McGill H-K, Vyas J, Shimauchi T, Tokura Y, Piguet V
  • Journal Title: Exp Dermatol Volume: 21(11) Pages: 815-21
• [Journal Article] Defective epidermal innate immunity and resultantn superficial dermatophytosis in adult T-cell leukemia/lymphoma (2012)
  • Author(s): Sawada Y, Namakura M, Kabashima-Kubo R, Shimauchi T, Kobayashi M, Tokura Y
  • Journal Title: Clin Cancer Res Volume: 18(14) Pages: 3772-9
• [Journal Article] Defective epidermal innate immunity and resultant superficial dermatophytosis in adult T-cell leukemia/lymphoma (2012)
  • Author(s): Sawada Y
  • Journal Title: Clin Cancer Res Volume: 18 Issue: 14 Pages: 3772-3779
  • DOI: 10.1158/1078-0432.ccr-12-0292
  • Peer Reviewed
• [Journal Article] HTLV-1-associated infective dermatitis: updates on the pathogenesis (2012)
  • Author(s): McGill NK
  • Journal Title: Exp Dermatol Volume: 21 Pages: 815-821
  • Peer Reviewed
• [Presentation] Adult T-cell Leukemia/Lymphoma: HTLV-1 infection and abnormal immune system (2012)
  • Author(s): Shimauchi T
  • Organizer: 37thAnnual Meeting of the Japanese Society for Investigative Dermatology, JSID-Asia-Oceania-Forum
  • Place of Presentation: Okinawa
• [Presentation] Adult T-cell Leukemia/Lymphoma: HTLV-1 infection and abnormal immune system (2012)
  • Author(s): Shimauchi T
  • Organizer: 37th Annual Meeting of the Japanese Society for Investigative Dermatology, JSID-Asia-Oceania-Forum
  • Place of Presentation: Okinawa, Japan
  • Invited
• [Book] 第2章 女性に特有の皮膚疾患 13 母乳でうつる皮膚疾患にはどんなものがあるか?女性の皮膚トラブル (2012)
  • Author(s): 島内隆寿/戸倉新樹
  • Publisher: 女性の皮膚トラブル FAQ 診断と治療社
• [Book] 女性の皮膚トラブルFAQ 第２章 女性に特有の皮膚疾患 １３ 母乳でうつる皮膚疾患にはどんなものがあるか？ (2012)
  • Author(s): 島内隆寿/戸倉新樹
  • Publisher: 診断と治療社