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The role of skin innate immune system in the pathogenesis of palmoplantar pustulosis

Research Project

Project/Area Number 22591235
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionEhime University (2012)
Asahikawa Medical College (2010-2011)

Principal Investigator

MURAKAMI Masamoto  愛媛大学, 医学部附属病院, 講師 (20278302)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords皮膚炎症・再生学 / 掌蹠膿疱症 / 皮膚自然免疫 / エクリン汗 / セリンプロテアーゼ / 皮膚自然免疫学 / 抗菌ペプチド / 病理学 / 免疫学
Research Abstract

There is no gold standard treatment for palmoplantar pustulosis yet because the pathogenesis of the disease is still unknown. Based on the recent finding that the acrosyringium is the main site of the vesicle formation in palmoplantar pustulosis, the role of skin innate immune systems in this disease such as TLRs, IL-17 relating cytokines, the antimicrobial peptide in pustule, and KLKs was observed. This investigation shows that the pathogenesis in palmoplantar pustulosis includes the different manner in the skin innate immune reactions.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (10 results)

  • [Journal Article] Over--Expression of Kallikrein Related Peptidases in Palmop antar Pustulosis2012

    • Author(s)
      Kaneko T, Muurakami M, KKishibe M,Braattsand M, Morhenn VB, Ishhida-Yamamooto A,Iizuuka H.
    • Journal Title

      J Dermatol Sci

      Volume: 67(1) Pages: 73-79

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 掌蹠膿疱症研究における最近の知見2012

    • Author(s)
      村上正基
    • Journal Title

      皮膚病診療

      Volume: 34(5) Pages: 426-431

    • Related Report
      2012 Final Research Report
  • [Journal Article] 汗管と掌蹠膿疱症の関係(汗管内水疱の発達)2012

    • Author(s)
      村上正基
    • Journal Title

      J Visual Dermatol

      Volume: 11 Pages: 1056-1058

    • Related Report
      2012 Final Research Report
  • [Journal Article] 掌蹠膿疱症とニコチン性アセチルコリン受容体、kallikrein related peptidase(KLK) と鱗屑について2012

    • Author(s)
      村上正基
    • Journal Title

      J Visual Dermatology

      Volume: 11 Pages: 1059-1063

    • Related Report
      2012 Final Research Report
  • [Journal Article] Over-Expression of Kallikrein Related Peptidases in Palmoplantar Pustulosis2012

    • Author(s)
      Kaneko T et al.
    • Journal Title

      J Dermatol Sci

      Volume: 67 Issue: 1 Pages: 73-76

    • DOI

      10.1016/j.jdermsci.2012.03.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 掌蹠膿疱症~最近の話題2012

    • Author(s)
      村上正基
    • Journal Title

      WHAT'S NEW in皮膚科学 2012-2013

      Pages: 60-61

    • Related Report
      2011 Annual Research Report
  • [Journal Article] The patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum2011

    • Author(s)
      Murakami M, et al
    • Journal Title

      Exp Dermatol

      Volume: 20(10) Pages: 845-847

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cathelicidin Antimicrobial Peptide LL-37 in Psoriasis Enables Keratinocyte Reactivity against TLR9 Ligands2011

    • Author(s)
      Morizane S, Yamasaki K, Muhleisen B, Kotol PF, Murakami M, Aoyama Y, Iwatsuki K, Hata T,Gallo RL
    • Journal Title

      J Invest Dermatol

      Volume: 132(1) Pages: 135-143

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 膿疱症の診療に役立つ知識掌蹠膿疱症研究における最近の話題2011

    • Author(s)
      村上正基
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 121(13) Pages: 2674-2675

    • Related Report
      2012 Final Research Report
  • [Journal Article] The patients with palmoplantar pustulosis have increased IL-17 and IL-22 levels both in the lesion and serum2011

    • Author(s)
      Murakami M, et al
    • Journal Title

      Experimental Dermatology

      Volume: 20 Pages: 845-847

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 掌蹠膿疱症発症メカニズムの解明2010

    • Author(s)
      村上正基
    • Journal Title

      旭川医科大学研究フォーラム

      Volume: 11(1) Pages: 67-68

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 1.蹠膿疱症患者におけるIL-17関連サイトカインの発現様式2012

    • Author(s)
      村上正基
    • Organizer
      第53回愛媛地方会
    • Place of Presentation
      愛媛、松山
    • Year and Date
      2012-03-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] The cathelicidin (hCAP-18/LL-37) expression in the granules of leukocytes in the pustules and perhipheral blood with palmoplantar pustulosis2012

    • Author(s)
      Murakami M, et al
    • Organizer
      37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Okinawa, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 掌蹠膿疱症と汗(エクリン汗関連物質)(シンポジウム5・汗と皮膚アレルギー)2012

    • Author(s)
      村上正基
    • Organizer
      第42回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
    • Place of Presentation
      軽井沢
    • Related Report
      2012 Final Research Report
  • [Presentation] Multiple over-expression of kallikrein related peptidases contributes to the inflammatory hyperkeratotic change with abnormal desquamation in lesions of palmoplantar pustulosis2012

    • Author(s)
      Murakami M, et al
    • Organizer
      75th Annual Meeting of The Society for Investigative Dermatology
    • Place of Presentation
      Scottsdale,USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Multiple over-expression of kallikrein related peptidases contributes to the inflammatory hyperkeratotic change with abnormal desquamation in lesions of palmoplantar pustulosis2012

    • Author(s)
      Murakami M et al.
    • Organizer
      75th Annual Meeting of The Society for Investigative Dermatology
    • Place of Presentation
      Raleigh, NC, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Different expression pattern of IL-17 related cytokines between lesional skin tissue and serum in the patients with palmoplantar pustulosis2011

    • Author(s)
      Murakami M
    • Organizer
      The Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] 掌蹠膿疱症研究に関するup date2011

    • Author(s)
      村上正基
    • Organizer
      第74回日本皮膚科学会東京支部学術大会
    • Place of Presentation
      東京 招待講演
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Different expression pattern of IL-17 related cytokines between lesional skin tissue and serum in the patients with palmoplantar pustulosis2011

    • Author(s)
      Murakami M, et al
    • Organizer
      36th Annual Meeting of The Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2012 Final Research Report
  • [Presentation] 掌蹠膿疱症研究に関するupdate(ランチョンセミナー4)2011

    • Author(s)
      村上正基
    • Organizer
      第74回日本皮膚科学会東京支部学術大会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Acrosyringium is a target of vesicle/pustule formation in pal moplantar pustulosis(pustulosis Palmaris et plantaris)2010

    • Author(s)
      Murakami M, et al
    • Organizer
      40^<th> Annual ESDR Meeting
    • Place of Presentation
      Helsinki, Finland
    • Year and Date
      2010-09-08
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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