The role of skin innate immune system in the pathogenesis of palmoplantar pustulosis
| Project/Area Number |
22591235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Ehime University (2012)
Asahikawa Medical College (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 皮膚炎症・再生学 / 掌蹠膿疱症 / 皮膚自然免疫 / エクリン汗 / セリンプロテアーゼ / 皮膚自然免疫学 / 抗菌ペプチド / 病理学 / 免疫学 |
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| Research Abstract |
There is no gold standard treatment for palmoplantar pustulosis yet because the pathogenesis of the disease is still unknown. Based on the recent finding that the acrosyringium is the main site of the vesicle formation in palmoplantar pustulosis, the role of skin innate immune systems in this disease such as TLRs, IL-17 relating cytokines, the antimicrobial peptide in pustule, and KLKs was observed. This investigation shows that the pathogenesis in palmoplantar pustulosis includes the different manner in the skin innate immune reactions.
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Report
(4 results)
Research Products
(21 results)
