The establishment of gadolinium-induced skin fibrosis and calcification mice model.

Research Project

Project/Area Number	22591237
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dermatology
Research Institution	Gunma University
Principal Investigator	ISHIKAWA Osamu 群馬大学, 大学院・医学系研究科, 教授 (90168188)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000) Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	腎性全身性線維症 / ガドリニウム / 線維化 / 石灰化 / 間葉系幹細胞 / 皮膚線維化 / 皮膚石灰化 / モデルマウス
Research Abstract	Nephrogenic systemic fibrosis (NSF) is an acquired disorder characterized by systemic fibrosis and abnormal calcification in patients with severe renal dysfunction. Growing evidence supports the hypothesis that gadolinium (Gd)-containing contrast agents used for magnetic resonance imaging trigger the development of NSF. The aim of this study was to establish the Gd-induced skin fibrosis and calcification mice model. Subcutaneous injection of bone marrow-derived mesenchymal stem cells and Gd-loaded hydorogel induced skin fibrosis in mice, but not skin calcification. Next we will examine the mechanism of Gd-induced skin fibrosis.