Approaches for the development of therapeutic tools of chronic pruritic and allergic diseases via targeting against eosinophils and basophils
| Project/Area Number |
22591238
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | 防衛医科大学校 (2012)
Tokyo Medical and Dental University (2010-2011) |
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Principal Investigator |
SATOH Takahiro 防衛医科大学校, 医学教育部医学科専門課程, 教授 (30235361)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 皮膚免疫 / 炎症学 / Itch / PGD2 / Basophils / Selectins / CRTH2受容体 / DP受容体 / 好塩基球 / 痒疹 / CD203c / Dendritic cells / STAT6 / 慢性接触過敏反応 / アレルギー性鼻炎 |
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| Research Abstract |
Itch accompanies various allergic skin diseases. Pruritus greatly impairs the quality of daily life. In this project, mechanisms of chronic allergic inflammations and itch were analyzed with various mouse allergic models where eosinophil and/or basophil infiltration is prominent. Receptors for PGD2 expressed on eosinophils and basophils were found to be promising therapeutic target for chronic allergic skin inflammations. Selectin-ligand generation in basophils appeared to be a key step for basophil recruitment to the skin, and thus, selectins also could be a potential therapeutic target for basophil-dependent skin diseases.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Verbalizing extremes of the visual analogue scale for pruritus- a consensus statement2013
Author(s)
Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan N-Q, Weisshaar E, Yosipovitch G, Staonder S
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Journal Title
Acta Derm-Venereol
Volume: 93
Pages: 214-215
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