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Approaches for the development of therapeutic tools of chronic pruritic and allergic diseases via targeting against eosinophils and basophils

Research Project

Project/Area Number 22591238
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research Institution防衛医科大学校 (2012)
Tokyo Medical and Dental University (2010-2011)

Principal Investigator

SATOH Takahiro  防衛医科大学校, 医学教育部医学科専門課程, 教授 (30235361)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords皮膚免疫 / 炎症学 / Itch / PGD2 / Basophils / Selectins / CRTH2受容体 / DP受容体 / 好塩基球 / 痒疹 / CD203c / Dendritic cells / STAT6 / 慢性接触過敏反応 / アレルギー性鼻炎
Research Abstract

Itch accompanies various allergic skin diseases. Pruritus greatly impairs the quality of daily life. In this project, mechanisms of chronic allergic inflammations and itch were analyzed with various mouse allergic models where eosinophil and/or basophil infiltration is prominent. Receptors for PGD2 expressed on eosinophils and basophils were found to be promising therapeutic target for chronic allergic skin inflammations. Selectin-ligand generation in basophils appeared to be a key step for basophil recruitment to the skin, and thus, selectins also could be a potential therapeutic target for basophil-dependent skin diseases.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (55 results)

All 2013 2012 2011 2010 Other

All Journal Article (25 results) (of which Peer Reviewed: 10 results) Presentation (16 results) (of which Invited: 3 results) Book (14 results)

  • [Journal Article] Hyperkeratotic variant of inflammatory disseminated superficial porokeratosis with lichenoid reaction and extensive amyloid deposition.2013

    • Author(s)
      Inazawa M, Satoh T, Yokozeki H.
    • Journal Title

      Int J Dermatol

      Volume: 53 Issue: 2

    • DOI

      10.1111/j.1365-4632.2012.05506.x

    • Year and Date
      2013-03-03
    • Related Report
      2012 Final Research Report
  • [Journal Article] Indomethacin inhibits eosinophil migration to prostaglandin D2: therapeutic potential of CRTH2 desensitization for eosinophilic pustular folliculitis2013

    • Author(s)
      Kataoka N, Satoh T, Hirai A, Saeki K, Yokozeki H.
    • Journal Title

      Immunology

      Volume: 140(1): Issue: 1 Pages: 78-86

    • DOI

      10.1111/imm.12112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] α(1,3) fucosyltransferases-IV and VII are essential for initial recruitment of basophils in chronic allergic inflammation2013

    • Author(s)
      Saeki K, Satoh T, Yokozeki H.
    • Journal Title

      J Invest Dermatol

      Volume: 133(9): Issue: 9 Pages: 2161-9

    • DOI

      10.1038/jid.2013.160

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IgG4-positive cells in skin lesions of cutaneous and systemic plasmacytosis2013

    • Author(s)
      Kato K, Satoh T, Tanaka-Fujimoto T, Ueda N, Yokozeki H.
    • Journal Title

      Eur J Dermatol

      Volume: 23 Issue: 2 Pages: 255-256

    • DOI

      10.1684/ejd.2013.1962

    • Related Report
      2012 Final Research Report
  • [Journal Article] Acrosyringeal involvement of palmoplantar lesions of eosnophilic pustular folliculitis2013

    • Author(s)
      Satoh T, Ikeda H, Yokozeki H.
    • Journal Title

      Acta Derm Venereol

      Volume: 93 Issue: 1 Pages: 99-99

    • DOI

      10.2340/00015555-1372

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Close association between metal allergy and nail lichen planus: detection of causative metals in nail lesions2013

    • Author(s)
      Nishizawa A, Satoh T, Yokozeki H.
    • Journal Title

      J Eur Acad Derm Venereol

      Volume: 27 Issue: 2 Pages: 231-234

    • DOI

      10.1111/j.1468-3083.2012.04561.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Verbalizing extremes of the visual analogue scale for pruritus- a consensus statement2013

    • Author(s)
      Furue M, Ebata T, Ikoma A, Takeuchi S, Kataoka Y, Takamori K, Satoh T, Saeki H, Augustin M, Reich A, Szepietowski J, Fleischer A, Blome C, Phan N-Q, Weisshaar E, Yosipovitch G, Staonder S
    • Journal Title

      Acta Derm-Venereol

      Volume: 93 Pages: 214-215

    • Related Report
      2012 Final Research Report
  • [Journal Article] Congenotal insensivitity to pain with anhidrosis: a case with preserved itch sensation to histamine and partial pain sensation2012

    • Author(s)
      Tanaka T, Satoh T, Tanaka A, Yokozeki H.
    • Journal Title

      Br J Dermatol

      Volume: 166 Issue: 4 Pages: 888-891

    • DOI

      10.1111/j.1365-2133.2011.10706.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-pruritic effects of topical crotamiton, capsaicin, and a corticosteroid on pruritogen-induced scratching behavior2012

    • Author(s)
      Sekine R, Satoh T, Takaoka A, Saeki K, Yokozeki H.
    • Journal Title

      Exp Dermatol

      Volume: 21 Issue: 3 Pages: 201-204

    • DOI

      10.1111/j.1600-0625.2011.01433.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired expression of Tim-3 on Th17 and Th1 cells in psoriasis2012

    • Author(s)
      Kanai Y, Satoh T, Yokozeki H.
    • Journal Title

      Acta Derm-Venereol

      Volume: 92 Issue: 4 Pages: 367-371

    • DOI

      10.2340/00015555-1285

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Erythrodermic psoriasis improved by panitumumab2012

    • Author(s)
      Nishizawa A, Satoh T, Yokozeki H.
    • Journal Title

      Acta Derm Venereol

      Volume: 92 Issue: 4 Pages: 360-361

    • DOI

      10.2340/00015555-1348

    • Related Report
      2012 Final Research Report
  • [Journal Article] Possible association of Henoch-Schoenlein purpura in adults with odontogenic focal infection2011

    • Author(s)
      Igawa K, Satoh T, Yokozeki H
    • Journal Title

      Int J Dermatol

      Volume: 50 Issue: 3 Pages: 277-279

    • DOI

      10.1111/j.1365-4632.2010.04657.x

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene silencing of STAT6 with siRNA ameliorates contact hypersensitivity and allergic rhinitis2011

    • Author(s)
      Hosoya K, Satoh T, Yamamoto Y, Saeki K, Igawa K, Okano M, Moriya T, Imamura O, Nemoto Y, Yokozeki H
    • Journal Title

      Allergy

      Volume: 66 Issue: 1 Pages: 124-131

    • DOI

      10.1111/j.1398-9995.2010.02440.x

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] Psoriasiform drug eruption due to abatacept2011

    • Author(s)
      Kato K, Satoh T, Nishizawa A, Yokozeki H.
    • Journal Title

      Acta Derm Venereol

      Volume: 91 Issue: 3 Pages: 362-363

    • DOI

      10.2340/00015555-1042

    • Related Report
      2012 Final Research Report
  • [Journal Article] Basophils infiltrate skin lesions of eosinophilic pustular folliculitis (Ofuji's disease)2011

    • Author(s)
      Satoh T, Ito Y, Miyagishi C, Yokozeki H
    • Journal Title

      Acta Derm Venereol

      Volume: 91 Issue: 3 Pages: 371-372

    • DOI

      10.2340/00015555-1052

    • Related Report
      2012 Final Research Report
  • [Journal Article] Basophil recruitment and activation in inflammatory skin diseases2011

    • Author(s)
      Ito Y, Satoh T, Takayama K, Miyagishi C, Walls AF, Yokozeki H
    • Journal Title

      Allergy

      Volume: 66 Issue: 8 Pages: 1107-1113

    • DOI

      10.1111/j.1398-9995.2011.02570.x

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH22011

    • Author(s)
      Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, Narumiya S, Yokozeki H, Nakamura M, Satoh T
    • Journal Title

      Am J Pathol

      Volume: 179 Issue: 1 Pages: 302-314

    • DOI

      10.1016/j.ajpath.2011.03.047

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] FcεRI, but not FcγR, signals induce prostaglandin D2 and E2 production from basophils2011

    • Author(s)
      Ugajin T, Satoh T, Kanamori T, Aritake K, Urade Y, Yokozeki H
    • Journal Title

      Am J Pathol

      Volume: 179 Issue: 2 Pages: 775-782

    • DOI

      10.1016/j.ajpath.2011.04.023

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] Distinct roles of prostaglandin D2 receptors in chronic skin inflammation2011

    • Author(s)
      Matsushima Y, Satoh T, Yamamoto Y, Nakamura M, Yokozeki H
    • Journal Title

      Mol Immunol

      Volume: 49 Issue: 1-2 Pages: 304-310

    • DOI

      10.1016/j.molimm.2011.08.023

    • Related Report
      2012 Final Research Report
  • [Journal Article] Indomethacin-induced reduction of CRTH2 in eosinophilic pustular folliculitis(Ofuji's disease): A proposed mechanism of action2010

    • Author(s)
      Satoh T, Shimura C, Miyagishi C, Yokozeki H
    • Journal Title

      Acta Derm Venereol

      Volume: 90 Issue: 1 Pages: 18-22

    • DOI

      10.2340/00015555-0759

    • Related Report
      2012 Final Research Report
  • [Journal Article] Dendritic cells express hematopoietic prostaglandin D synthase and function as a source of prostaglandin D2 in the skin2010

    • Author(s)
      Shimura C, Satoh T, Igawa K, Aritake K, Urade Y, Nakamura M, Yokozeki H
    • Journal Title

      Am J Pathol

      Volume: 176 Issue: 1 Pages: 227-237

    • DOI

      10.2353/ajpath.2010.090111

    • Related Report
      2012 Final Research Report
  • [Journal Article] Hydroa vacciniforme with mucosal involvement and recalcitrant periodontitis and multiple virus re-activation after sun exposure2010

    • Author(s)
      Nishizawa A, Satoh T, Takayama K, Yokozeki H
    • Journal Title

      Acta Derm Venereol

      Volume: 90 Issue: 5 Pages: 498-501

    • DOI

      10.2340/00015555-0913

    • Related Report
      2012 Final Research Report
  • [Journal Article] Systemic nickel allergy presenting as papuloerythroderma-loke eruptions2010

    • Author(s)
      Kato K, Satoh T, Tanaka T, Ueda N, Yokozeki H
    • Journal Title

      Acta Derm Venereol

      Volume: 90 Issue: 6 Pages: 655-656

    • DOI

      10.2340/00015555-0965

    • Related Report
      2012 Final Research Report
  • [Journal Article] Indomethacin-induced reduction of CRTH2 in eosinophilic pustular follic ulitis : A proposed mechanism of action2010

    • Author(s)
      Satoh T, et al.
    • Journal Title

      Acta Derm-Venereol

      Volume: 90 Pages: 18-22

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cells express hematopoietic prostaglandin synthase and function as a source of prostaglandin D2 in the skin2010

    • Author(s)
      Shimura C, et al.
    • Journal Title

      Am J Pathol

      Volume: 176 Pages: 227-237

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Protective roles of STAT6 in basophil-dependent prurigo-like reactions2012

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H
    • Organizer
      The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Naha, Okinawa
    • Year and Date
      2012-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Indomethacin-induced inhibition of eosinophil chemotaxis via CRTH2: proposal of a mechanism of action for eosinophilic pustular folliculitis2011

    • Author(s)
      Kataoka N, Satoh T, Yokozeki H
    • Organizer
      The 36^<th> Annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Inactivated Sendai Virus particles with and IL-2 gene exert anti-tumor effects on murine angiosarcoma.2011

    • Author(s)
      Takehara Y, Satoh T, Nishizawa A, Masuzaya M, Yokozeki H
    • Organizer
      The 36^<th> Annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Hyperkeratotic type of palmoplantar eczematous reaction: a variant of dyshidrotic eczema?2011

    • Author(s)
      Nishizawa A, Satoh T, Yokozeki H
    • Organizer
      The 36th Annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Repeated induction of IgE-mediated chronic allergic skin inflammation induces prurigo-like reaction2011

    • Author(s)
      Hashimoto T, Satoh T, Yokozeki H
    • Organizer
      The 36^<th> Annual meeting of the Japanese Society for Investigative Dermatology
    • Place of Presentation
      Kyoto
    • Year and Date
      2011-12-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Inactivated Sendai virus particles with an IL-2 gene exert anti-tumor effects on murine angiosarcoma2011

    • Author(s)
      Takehara Y, Satoh T, Nakamura M, Yokozeki H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] L-selectin ligand synthesis by α(1,3) fucosyltransferases is essential for initial recruitment of basophils and development of chronic allergic inflammation2011

    • Author(s)
      Saeki K, Satoh T, Yokozeki H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Distinct roles of PGD2 receptors in chronic skin inflammation2011

    • Author(s)
      Yamamoto Y, Satoh T, Nakamura M, Yokozeki H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2012 Final Research Report
  • [Presentation] Prostaglandin D2 and eosinophilic skin diseases2011

    • Author(s)
      Satoh T
    • Organizer
      22^<nd> World congress of Dermatology
    • Place of Presentation
      Seoul
    • Year and Date
      2011-05-28
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Collaborative control of α(1,3) fucosyltransferases-IV and VII for the selectin-dependent initial recruitment of basophils in chronic allergic inflammation2010

    • Author(s)
      Saeki K, Satoh T, Yokozeki H
    • Organizer
      14^<th> International Congress of Immunology,
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Deficiency of PGD2 signals enhances contact hypersensitivity via promotion of Th17 and Th1 immunity2010

    • Author(s)
      Yamamoto Y, Satoh T, Otani S, Narumiya S, Nakamura M, Yokozeki H
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Prostaglandin D2 and E2 production from murine basophils2010

    • Author(s)
      Ugajin T, Satoh T, Kanamori T, Yamamoto Y, Matsushima Y, Yokozeki H
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-24
    • Related Report
      2012 Final Research Report
  • [Presentation] 感作性物質評価法の最近の進歩2010

    • Author(s)
      佐藤貴浩
    • Organizer
      第109回日本皮膚科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-04-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Hypereosinophilic syndrome

    • Author(s)
      佐藤貴浩
    • Organizer
      第48回湯島皮膚科談話会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 痒疹の考え方と諸問題

    • Author(s)
      佐藤貴浩
    • Organizer
      日本皮膚科学会岩手地方会学術大会第360回例会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 痒疹をどう考えるか

    • Author(s)
      佐藤貴浩
    • Organizer
      第17回ぎんなん皮膚科談話会
    • Place of Presentation
      大阪
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] アトピー性皮膚炎 今日の小児治療指針 第15版2012

    • Author(s)
      佐藤貴浩,総編集 大関武彦 古川 漸 横田俊一郎 水口 雅
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 好酸球・好中球 1冊でわかる皮膚アレルギー2012

    • Author(s)
      佐藤貴浩,ゲスト編集 塩原哲夫 常任編集 宮地良樹 清水宏
    • Publisher
      文光堂
    • Related Report
      2012 Final Research Report
  • [Book] 結節性痒疹 今日の皮膚疾患治療指針 第4版2012

    • Author(s)
      佐藤貴浩,編集 塩原哲夫 宮地良樹 渡辺晋一 佐藤伸一
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 妊娠性痒疹 今日の皮膚疾患治療指針 第4版2012

    • Author(s)
      佐藤貴浩,編集 塩原哲夫 宮地良樹 渡辺晋一 佐藤伸一
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 今日の小児治療指針ーアトピー性皮膚炎2012

    • Author(s)
      佐藤貴浩
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] 1冊でわかる皮膚アレルギーー好酸球・好中球2012

    • Author(s)
      佐藤貴浩
    • Total Pages
      3
    • Publisher
      文光堂
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の皮膚疾患治療指針ー結節性痒疹2012

    • Author(s)
      佐藤貴浩
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] ウエルズ症候群, 症候群ハンドブック2011

    • Author(s)
      佐藤貴浩,総編集 井村裕夫
    • Total Pages
      509
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] ウエルズ症候群:症候群ハンドブック2011

    • Author(s)
      佐藤貴浩
    • Total Pages
      1
    • Publisher
      中山書店
    • Related Report
      2011 Annual Research Report
  • [Book] E免疫学的検査, 疾病と検査, 看護学テキストNICE2010

    • Author(s)
      佐藤貴浩,総編集 松田暉, 荻原俊男, 難波光義, 鈴木久美子, 林直子
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 5好酸球・好中球, ファーストステップ皮膚免疫学2010

    • Author(s)
      佐藤貴浩 ,編著 戸倉新樹,
    • Publisher
      中外医学社
    • Related Report
      2012 Final Research Report
  • [Book] 7.抗ヒスタミン薬・抗アレルギー薬, インフォームドコンセントのための図説シリーズ, アトピー性皮膚炎2010

    • Author(s)
      佐藤貴浩,改訂版 監修西岡清 片山一朗編
    • Publisher
      医薬ジャーナル社
    • Related Report
      2012 Final Research Report
  • [Book] 金属などの歯科材料によるアレルギーが疑われる患者が来院したら?-その診断と治療方針についてー,医師・歯科医師のための口腔診療必携(困った時のマニュアルヒント集202)2010

    • Author(s)
      佐藤貴浩,監修 高戸 毅
    • Total Pages
      206
    • Publisher
      金原出版
    • Related Report
      2012 Final Research Report
  • [Book] 5好酸球・好中球(ファーストステップ皮膚免疫学)2010

    • Author(s)
      佐藤貴浩
    • Total Pages
      8
    • Publisher
      中外医学社
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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