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Analysis of human sweat antigen and development of a simple diagnostic method of human sweat allergy

Research Project

Project/Area Number 22591239
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Dermatology
Research InstitutionHiroshima University

Principal Investigator

MIHARA Shoji  広島大学, 大学院・医歯薬保健学研究院, 准教授 (90325168)

Co-Investigator(Kenkyū-buntansha) ISHI Kaori  広島大学, 大学院・医歯薬保健学研究院, 研究員 (90448267)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアレルギー・ぜんそく / IgE / 汗 / アトピー性皮膚炎 / アレルギー・喘息
Research Abstract

To identify and characterize sweat antigen which is the major aggravating factor of atopic dermatitis, human basophil histamine releasing activity in sweat was purified by a combination of chromatographies and proteins were analyzed with mass spectrometry. Some candidate peptides for sweat antigen were obtained. To measure specific IgE against sweat antigen in patients with atopic dermatitis, a simple detection system using anti-sweat monoclonal antibody and semi-purified sweat antigen was established.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] アトピー性皮膚炎2013

    • Author(s)
      三原祥嗣
    • Journal Title

      Clinical Derma

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Journal Article] アレルギー性皮膚疾患-アトピー性皮膚炎、蕁麻疹の重症度と客観的評価法-2012

    • Author(s)
      三原祥嗣
    • Journal Title

      アレルギー

      Volume: Vol61 Pages: 10-18

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Journal Article] アトピー性皮膚炎に対するタンニン酸配合湯上がり製剤およびスプレー剤の臨床有用性の検討2011

    • Author(s)
      信藤肇、高萩俊輔、三原祥嗣、田中稔彦、石井香、他
    • Journal Title

      アレルギー

      Volume: Vol60 Pages: 33-42

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] アトピー性皮膚炎に対するタンニン酸配合湯上がり製剤およびスプレー剤の臨床有用性の検討2011

    • Author(s)
      信藤肇, 高萩俊輔, 三原祥嗣, 田中稔彦, 石井香, 秀道広, 鈴木茂, 金谷裕敏, 谷野伸吾
    • Journal Title

      アレルギー

      Volume: 60 Pages: 33-42

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 汗アレルギーとアトピー性皮膚炎2010

    • Author(s)
      信藤肇、高萩俊輔、石井香、三原祥嗣、他
    • Journal Title

      アレルギーの臨床

      Volume: Vol30 Pages: 416-421

    • Related Report
      2012 Final Research Report
  • [Journal Article] 精製汗抗原を用いた年齢別汗アレルギーの検討2010

    • Author(s)
      信藤肇、高萩俊輔、石井香、三原祥嗣、他
    • Journal Title

      Visual Dermatology

      Volume: Vol9 Pages: 1026-1028

    • Related Report
      2012 Final Research Report
  • [Journal Article] 小児アトピー性皮膚炎における汗アレルギーの検討2010

    • Author(s)
      信藤肇、高萩俊輔、石井香、三原祥嗣、他
    • Journal Title

      日本小児皮膚科学会雑誌

      Volume: Vol29 Pages: 97-102

    • NAID

      10027698435

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 小児アトピー性皮膚炎における汗アレルギーの検討2010

    • Author(s)
      信藤肇, 高萩俊輔, 石井香, 三原祥嗣, 亀好良一, 秀道広, 片岡葉子, 藤澤隆夫, 有田昌彦
    • Journal Title

      日本小児皮膚科学会雑誌

      Volume: 29 Pages: 97-102

    • NAID

      10027698435

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 精製汗抗原を用いた年齢別汗アレルギーの検討2010

    • Author(s)
      信藤肇, 高萩俊輔, 石井香, 三原祥嗣, 亀好良一, 秀道広, 片岡葉子, 藤澤隆夫, 有田昌彦
    • Journal Title

      Visual Dermatology

      Volume: 9 Pages: 1026-1028

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 汗アレルギーとアトピー性皮膚炎2010

    • Author(s)
      信藤肇, 高萩俊輔, 石井香, 三原祥嗣, 秀道広
    • Journal Title

      アレルギーの臨床

      Volume: 30 Pages: 416-421

    • Related Report
      2010 Annual Research Report
  • [Presentation] 免疫療法その機序と効果皮膚アレルギーにおける免疫療法2011

    • Author(s)
      三原祥嗣、信藤肇、秀道広
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 免疫療法その機序と効果 皮膚アレルギーにおける免疫療法2011

    • Author(s)
      三原祥嗣、信藤 肇、秀 道広
    • Organizer
      第61回日本アレルギー学会秋季学術大会
    • Place of Presentation
      東京都
    • Year and Date
      2011-01-05
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎克服のための挑戦と実際 アトピー性皮膚炎における汗アレルギーと対策2010

    • Author(s)
      三原祥嗣
    • Organizer
      第40回日本皮膚アレルギー・接触皮膚炎学会
    • Place of Presentation
      広島市
    • Year and Date
      2010-12-11
    • Related Report
      2012 Final Research Report
  • [Presentation] アトピー性皮膚炎克服のための挑戦と実際 アトピー性皮膚炎における汗アレルギーと対策2010

    • Author(s)
      三原祥嗣
    • Organizer
      第40回日本皮膚アレルギー・接触皮膚炎学会
    • Place of Presentation
      広島市(招待講演)
    • Year and Date
      2010-12-11
    • Related Report
      2010 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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