A study on cell therapy in the treatment of refractory woundsusing gene transferred macrophages

Research Project

Project/Area Number	22591248
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Dermatology
Research Institution	Kyoto Prefectural University of Medicine
Principal Investigator	TAKENAKA Hideya 京都府立医科大学, 医学研究科, 准教授 (80254358)
Co-Investigator(Kenkyū-buntansha)	ASAI Jun 京都府立医科大学, 医学研究科, 助教 (50438222)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	皮膚炎症 / 再生学 / 移植・再生医療 / 創傷治癒
Research Abstract	We investigated the effects of hepatocyte growth factor gene transfer to macrophages of diabetic mice. These gene transferred macrophages showed promoted tube formation. We also investigated the roles of macrophages during wound healing in diabetic mice. Statin treatment promoted infiltration of macrophages in granulation tissues. These macrophages produced vascular endothelial growth factor C, which induces lymphatic vessel formation.

Report

(4 results)