Approaches for the restoration of dysfunctional regulatory T cell in severe drug reactions
| Project/Area Number |
22591250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | Kyorin University |
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Principal Investigator |
KANO Yoko 杏林大学, 医学部, 教授 (20142416)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Stevens-Johnson 症候群 / 中毒性表皮壊死症 / 薬剤性過敏症症候群 / 薬疹 / 制御性T細胞 / 治療 / Stevens-Johnson症候群 / ステロイドパルス療法 / マイコプラズマ / リンパ球 / ヘルペスウイルス / Toxic Epidermal necrolysis / 薬剤性過敏症候群 |
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| Research Abstract |
Regulatory T cells (Treg) are involved in the pathomechanisms of severe drug reactions. To detect the roles of Treg in the drug reactions, alterations of level of lymphocyte transformation test and various markers, and reactivation of human herpesviruses were clarified. The results showed that differences in functional and proliferative response of Treg were strongly associated with those in the clinical phenotype of drug eruptions. Our results will contribute to the development of new treatment strategy for severe drug reactions.
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Report
(4 results)
Research Products
(100 results)
