| Project/Area Number |
22591253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
ISHII Norihisa 国立感染症研究所, ハンセン病研究センター, センター長 (50159670)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Koichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (20206478)
MORI Syuichi 国立感染症研究所, ハンセン病研究センター感染制御部, 室長 (40559522)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ハンセン病 / らい菌 / 細胞内寄生 / 感染症 / 細菌 |
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| Research Abstract |
Upon infection, Mycobacterium leprae (M. leprae), a causative agent of leprosy, modulates expression and localization of host proteins necessary for inhibition of phagosome-lysosome fusion, and for lipid accumulation or catabolism to create cellular microenvironment that is favorable for its intracellular parasitization. Only live M. leprae, but not heat-killed M. leprae had such effects. One of the drugs used to treat leprosy, clofazimine, suppressed such effects of M. leprae.
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