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xperimental study for staging strategy establishment of schizophrenia

Research Project

Project/Area Number 22591255
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionHokkaido University

Principal Investigator

ABEKAWA Tomohiro  北海道大学, 大学院・医学研究科, 客員准教授 (80301901)

Co-Investigator(Kenkyū-buntansha) KITAICHI Yuji  北海道大学, 大学院・医学研究科, 客員講師 (80374445)
伊藤 侯輝  北海道大学, 大学院・医学研究科, 助教 (40455663)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords統合失調症 / Staging strategy / 薬物療法 / 病態モデル / 実験研究
Research Abstract

In this study, we divided into the progress pathophysiology-stage and the subsequent residual-stage and examined the effects of second generation antipsychotics, mood stabilizers and medicine which stimulate NMDA receptor function in both stages and this research aimed at the establishment of suitable medication according to stages. From the results of this research, medicine which prevents the increases of extracellular glutamate concentration may have blocking effects in the progressive pathophysiology-stage and medicine which stimulate glutamatergic neurotransmission may recover in the subsequent residual-stage.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (8 results)

  • [Journal Article] Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice2013

    • Author(s)
      Kitaichi Y
    • Journal Title

      Acta Neuropsychiatrica

      Volume: 印刷中 Issue: 4 Pages: 215-220

    • DOI

      10.1111/acn.12018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Innovation of an animal model for the pathophysiology of schizophrenia2012

    • Author(s)
      Abekawa T, Ito K, Nakato Y, Koyama T
    • Journal Title

      精神神経学雑誌

      Volume: 114巻 Pages: 81-89

    • NAID

      10030969296

    • Related Report
      2012 Final Research Report
  • [Journal Article] Innovation of an animal model for the pathophysiology of schizophrenia2012

    • Author(s)
      Abekawa T
    • Journal Title

      精神神経学雑誌

      Volume: 114 Pages: 81-98

    • NAID

      10030969296

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Developmental GABAergic deficit enhances methamphetamine-induced apoptosis2011

    • Author(s)
      Abekawa T, Ito K, Nakato Y, Koyama T
    • Journal Title

      Psychopharmacology.

      Volume: 215巻 Pages: 413-427

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lamotrigine blocks repeated high-dose methamphetamine-induced behavioral sensitization to dizocilpine (MK-801), but not methamphetamine in rats2011

    • Author(s)
      Nakato Y, Abekawa T, Inoue T, Ito K, Koyama T
    • Journal Title

      Neurosci Lett

      Volume: 504巻 Pages: 131-134

    • NAID

      120003413070

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Developmental GABAergic deficit enhances methamphetamine-induced apoptosis2011

    • Author(s)
      Abekawa T, Ito K, Nakato Y, Koyama T
    • Journal Title

      Psychopharmacology

      Volume: 215 Pages: 413-427

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of aripiprazole and haloperidol on progression to schizophrenia-like behavioural abnormalities and apoptosis in rodents2010

    • Author(s)
      Abekawa T, Ito K, Nakagawa S, Nakato Y, Koyama T
    • Journal Title

      Schizophrenia Research

      Volume: 125巻 Pages: 77-87

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lamotrigine blocks the initiation and expression of repeated high-dose methamphetamine-induced prepulse inhibition deficit in rats2010

    • Author(s)
      Nakato Y, Abekawa T, Ito K, Inoue T, Koyama T
    • Journal Title

      Neurosci Lett

      Volume: 481巻 Pages: 183-187

    • NAID

      120002386834

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lamotrigine blocks apoptosis induced by repeated administration of high-dose methamphetamine in the medial prefrontal cortex of rats2010

    • Author(s)
      Nakato Y, Abekawa T, Ito K, Inoue T, Koyama T
    • Journal Title

      Neurosci Lett

      Volume: 490巻 Pages: 161-164

    • NAID

      120003354965

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of aripiprazole and haloperidol on progression to schizophrenia-like behavioural abnormalities and apoptosis in rodents.2010

    • Author(s)
      Abekawa T, Ito K, Nakagawa S, Nakato Y, Koyama T.
    • Journal Title

      Schizophrenia Research.

      Volume: 125 Pages: 77-87

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamotrigine blocks the initiation and expression of repeated high-dose methamphetamine-induced prepulse inhibition deficit in rats.2010

    • Author(s)
      Nakato Y, Abekawa T, Ito K, Inoue T, Koyama T.
    • Journal Title

      Neurosci Lett.

      Volume: 481 Pages: 183-187

    • NAID

      120002386834

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lamotrigine blocks apoptosis induced by repeated administration of high-dose methamphetamine in the medial prefrontal cortex of rats.2010

    • Author(s)
      Nakato Y, Abekawa T, Ito K, Inoue T, Koyama T.
    • Journal Title

      Neurosci Lett.

      Volume: 490 Pages: 161-164

    • NAID

      120003354965

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice

    • Author(s)
      Kitaichi Y, Hashimoto R, Inoue T, Abekawa T, Kakuta A, Hattori S, Koyama T
    • Journal Title

      Acta Neuropsychiatrica

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] The mGluR2/3 agonist LY379268 blocks a high-dosemethamphetamine-induced increase in extracellular glutamate levels in the medial prefrontal.2011

    • Author(s)
      Ito K
    • Organizer
      The 41th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      USA、Washington ConventionCenter
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] The mGluR2/3 agonist LY379268 blocks a high-dose methamphetamine-induced increase in extracellular glutamate levels in the medial prefrontal2011

    • Author(s)
      Ito K, Abekawa T, Nakato Y, Koyama T
    • Organizer
      Neuroscience 2011
    • Place of Presentation
      Washington Convention Center (Washington DC, USA)(招待講演)
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高用量の覚せい剤反復投与によって成立したPPI障害におけるolanzapine、risperidone、valproate の回復効果に対する実験的検討2011

    • Author(s)
      伊藤侯輝
    • Organizer
      第41回日本神経精神薬理学会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2011-10-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 高用量の覚せい剤反復投与によって成立したPPI障害におけるolanzapine、risperidone、valproateの回復効果に関する実験的検討2011

    • Author(s)
      伊藤侯輝、安部川智浩、仲唐安哉、井上猛、小山司
    • Organizer
      第41回日本神経精神薬理学会
    • Place of Presentation
      京王プラザホテル(東京都)(招待講演)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Quetiapine blocks high-dose methamphetamine-induced apoptosis in the medial prefrontal cortex and the accompanying PPI deficit.2010

    • Author(s)
      Ito K
    • Organizer
      The 40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      USA、San Diego ConventionCenter
    • Year and Date
      2010-11-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Quetiapine blocks high-dose methamphetamine-induced apoptosis in the medial prefrontal cortex and the accompanying PPI deficit.2010

    • Author(s)
      Ito K, Abekawa T, Nakato Y, Koyama T
    • Organizer
      The 40th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego, USA (Diego Convention Center) 招待講演
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高用量の覚せい剤によって誘発されるMK-801に対する行動上の感受性亢進とPPI障害の発現過程におけるclonazepamの阻止効果2010

    • Author(s)
      伊藤侯輝
    • Organizer
      第40回日本神経精神薬理学会
    • Place of Presentation
      仙台、仙台国際センター
    • Year and Date
      2010-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 高用量の覚せい剤によって誘発されるMK-801に対する行動上の感受性亢進とPPI障害の発現過程におけるclonazepamの阻止効果2010

    • Author(s)
      伊藤侯輝、安部川智浩、仲唐安哉、井土猛、小山司
    • Organizer
      第40回日本神経精神薬理学会
    • Place of Presentation
      仙台(仙台国際センター) 招待講演
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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