• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Genome-wide association study of panic disorder in the Japanese population.

Research Project

Project/Area Number 22591256
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe University of Tokyo

Principal Investigator

UMEKAGE Tadashi  東京大学, 環境安全本部, 准教授 (20323587)

Co-Investigator(Renkei-kenkyūsha) SASAKI Tsukasa  東京大学, 教育学研究科, 教授 (50235256)
OTOWA Kenji  東京大学, 医学部附属病院, 助教 (70456119)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsPanic Disorder, GWAS, SNP / Panic Disorder / GWAS / SNP / Panic disorder
Research Abstract

In this study, we conducted a genome-wide association study (GWAS) in two independent data sets using the Affymetrix Mapping 500K Array or Genome-Wide Human SNP Array 6.0. We obtained imputed genotypes for each GWAS and performed a meta-analysis of two GWAS data sets (718 cases and 1717 controls). For follow-up, 12 single-nucleotide polymorphisms (SNPs) were tested in 329 cases and 861 controls. Gene ontology enrichment and candidate gene analyses were conducted using the GWAS or meta-analysis results. We also applied the polygenic score analysis to our two GWAS samples to test the hypothesis of polygenic components contributing to PD. Our findings suggest that large sets of common variants of small effects collectively account for risk of PD.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (5 results)

  • [Journal Article] Prevalence of bipolar disorder in panic disorder patients in the Japanese population.2013

    • Author(s)
      Sugaya N,Otowa T 7/18, Umekage T 9/18, Sasaki T17/18
    • Journal Title

      J Affect Disord.

      Volume: 147(1-3) Issue: 1-3 Pages: 411-5

    • DOI

      10.1016/j.jad.2012.10.014

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Meta-analysis of genome-wide association studies for panic disorder in Japanese population.2012

    • Author(s)
      Otowa T 1/32, Umekage T 17/32, Sasaki T 32/32
    • Journal Title

      Translational Psychiatry

      Volume: 13;2 Issue: 11 Pages: 1-8

    • DOI

      10.1038/tp.2012.89

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A genome-wide CNV association study on panic disorder in a Japanese population2011

    • Author(s)
      Kawamura Y., et al
    • Journal Title

      J Hum Genet

      Volume: 56 Issue: 12 Pages: 852-856

    • DOI

      10.1038/jhg.2011.117

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An association analysis of Per2 with panic disorder in the Japanese population.2011

    • Author(s)
      Otowa T 1/14, Umekage T 8/14, Sasaki T14/14
    • Journal Title

      J Hum Genet.

      Volume: 56(10) Issue: 10 Pages: 748-50

    • DOI

      10.1038/jhg.2011.94

    • NAID

      10030661455

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of RGS2 variants with panic disorder in a Japanese population.2011

    • Author(s)
      Otowa T1/16, Umekage T 11/16 , Sasaki T16/16
    • Journal Title

      Am J Med Genet B Neuropsychiatr Genet.

      Volume: 156B(4) Issue: 4 Pages: 430-4

    • DOI

      10.1002/ajmg.b.31178

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of PDE4B with panic disorder in the Japanese population.2011

    • Author(s)
      Otowa T 1/14, Umekage T 8/14, Sasaki T14/14
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 35(2) Issue: 2 Pages: 545-9

    • DOI

      10.1016/j.pnpbp.2010.12.013

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] association between CLOCK gene 3111C/T polymorphism and personality traits in healthy Japanese subjects.2011

    • Author(s)
      Otowa T 1/7,Umekage T 3/7, Sasaki T 7/7, No
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: t;65(6) Pages: 604-604

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] No association between CLOCK gene 3111C/T polymorphism and personality traits in healthy Japanese subjects2011

    • Author(s)
      Otowa T, Tochigi M, Umekage T, Ebisawa T, Kasai K, Kato N, Sasaki T
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 65(6) Issue: 6 Pages: 604-604

    • DOI

      10.1111/j.1440-1819.2011.02259.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association study of PDE4B with panic disorder in the Japanese population.2011

    • Author(s)
      Otowa T, et. al.
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry.

      Volume: 35(2) Pages: 545-549

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replication of a genome-wide association study of panic disorder in a Japanese population.2010

    • Author(s)
      Otowa T 1/17, Umekage T 11/17, Sasaki T17/17
    • Journal Title

      Journal of Human Genetics

      Volume: 55(2) Issue: 2 Pages: 91-6

    • DOI

      10.1038/jhg.2009.127

    • NAID

      10030733614

    • ISSN
      1434-5161, 1435-232X
    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Meta-analysis of genome-wide association studies for panic disorder in the Japanese population.2012

    • Author(s)
      Otowa T 1/32, Umekage T 17/32, Sasaki T32/32
    • Organizer
      The 20thWorld Congress of Psychiatric Genetics
    • Place of Presentation
      Hamburg
    • Related Report
      2012 Final Research Report
  • [Presentation] A genome-wide CNV association study on panic disorder in a Japanese population2012

    • Author(s)
      T. Otowa
    • Organizer
      XXth World Congress of Psychiatric Genetics
    • Place of Presentation
      Hamburg, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] A genome-wide CNV association study on panic disorder in a Japanese population.2010

    • Author(s)
      Kawamura Y, et. al.
    • Organizer
      XVIII World Congress on Psychiatric Genetics
    • Place of Presentation
      Divani Caravel Hotel (Athens, Greece)
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] A genome-wide CNV association study on panic disorder in a Japanese population.2010

    • Author(s)
      Kawamura Y1/20, Otowa T 2/20, Umekage T 14/20, Sasaki T 20/20
    • Organizer
      XVIII World Congress on Psychiatric
    • Place of Presentation
      Athens
    • Related Report
      2012 Final Research Report
  • [Presentation] A Randomized Controlled Trial (RCT) of Computerized Cognitive-Behavior Therapy (CCBT) for Panic Disorder with Agoraphobia.2010

    • Author(s)
      I Fukui1/8, Umekage T 6/8
    • Organizer
      The World Congress of Behavioral and Cognitive Therapies
    • Place of Presentation
      Boston
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi