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Biological study of obsessive-compulsive disorder using brain imaging and the molecular genetics

Research Project

Project/Area Number 22591262
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionKyushu University

Principal Investigator

KAWASAKI Hiroaki  九州大学, 医学研究院, 准教授 (50224762)

Co-Investigator(Kenkyū-buntansha) NAKAO Tomohiro  九州大学, 大学病院, 講師 (50423554)
MITUYASU Hiroshi  九州大学, 大学病院, 助教 (00533176)
SANEMATSU Hirokuni  九州大学, 大学病院, 助教 (30588116)
YOSHIURA Takashi  九州大学, 医学研究科, 准教授 (40322747)
Co-Investigator(Renkei-kenkyūsha) KANBA Shigenobu  九州大学, 医学研究科, 教授 (50195187)
NAKAGAWA Akiko  千葉大学, 医学研究科, 教授 (70253424)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords臨床精神分子遺伝学 / 強迫性障害 / MRI / 遺伝子 / セロトニントランスポーター / 画像解析 / 神経画像 / 症状亜型 / 中間表現型
Research Abstract

Eighty-nine obsessive and compulsive disorder (OCD) patients and 89 healthy controls were genotyped with L- and s- types polymorphisms of 5HTT -LPR. As a result, OCD patients with current and/or past comorbid depression had a statistically higher frequency of the L-allele. The result suggested that the L-allele might be associated with the comorbidity depression with OCD.Magnetic resonance imaging examinations of 37 OCD patients and 37 healthy controls (HCs) were carried out. W e found significant reductions in right posterior cingulate cortexand some other areas in the OCD patients compared to healthy controls (HCs). In addition, we found specific correlations between the type of the obsession symptom and the volume of the specific area of the brain. The pathophysiology of OCD may involve widely distributed neural systems. Moreover, there are distinct correlations among symptomatic dimensions and structural abnormalities.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2013 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (10 results) Book (13 results)

  • [Journal Article] Meta-analysis of Functional Magnetic Resonance Imaging Studies of Inhibition and Attention in Attention-deficit/ Hyperactivity Disorder: Exploring Task-Specific, Stimulant Medication, and Age Effects.2013

    • Author(s)
      Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K
    • Journal Title

      JAMA Psychiatry

      Volume: 70(2) Issue: 2 Pages: 185-198

    • DOI

      10.1001/jamapsychiatry.2013.277

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential neural network of checking versus washing symptoms in obsessive-compulsivedisorder2012

    • Author(s)
      Murayama K, Nakao T, Sanematsu H, Okada K, Yoshiura T, Tomita M, Masuda Y, Isomura K, Nakagawa A, Kanba S
    • Journal Title

      PROGRESS IN NEUROPSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

      Volume: 40巻 Pages: 160-6

    • DOI

      10.1016/j.pnpbp.2012.09.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic ormixed episodes in Asian patients with bipolar I disorder (the AMAZE study)2012

    • Author(s)
      Kanba S, Kawasaki H, Ishigooka J, Sakamoto K, Kinoshita T, Kuroki T
    • Journal Title

      World J Biol Psychiatry

      Volume: Epub ahead of print Issue: 2 Pages: 1-9

    • DOI

      10.3109/15622975.2012.669047

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nominal association between a polymorphism in DGKH and bipolardisorder detected in a meta-analysis of East Asian case-control samples2011

    • Author(s)
      Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H, Miura T, Kato T,Yoshikawa T, Kanba S
    • Journal Title

      Psychiatry Clin Neurosci

      Volume: 65(3) Issue: 3 Pages: 280-5

    • DOI

      10.1111/j.1440-1819.2011.02193.x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] fMRI of patients with social anxiety disorder during a social situation task2011

    • Author(s)
      Nakao T, Sanematsu H, Yoshiura T, Togao O, Murayama K, Tomita M, Masuda Y, Kanba S
    • Journal Title

      Neurosci Res

      Volume: 69 Issue: 1 Pages: 67-72

    • DOI

      10.1016/j.neures.2010.09.008

    • NAID

      10028190256

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gray Matter Volume Abnormalities in ADHD : Voxel-Based Meta-Analysis Exploring the Effects of Age and Stimulant Medication2011

    • Author(s)
      Nakao T.
    • Journal Title

      Am J Psychiatry

      Volume: 168 Pages: 1154-1163

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OCDの病態仮説と治療理論2011

    • Author(s)
      中尾智博
    • Journal Title

      精神神経誌

      Volume: 113 Pages: 26-27

    • NAID

      10028060411

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder: An fMRI study2010

    • Author(s)
      Sanematsu H, Nakao T, Yoshiura T, Nabeyama M, Togao O, Tomita M, Masuda Y, Yoshioka K, Nakatani E, Nakagawa A, Kanba S
    • Journal Title

      J Psychiatr Res

      Volume: 44 Issue: 4 Pages: 193-200

    • DOI

      10.1016/j.jpsychires.2009.08.007

    • NAID

      120005289467

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study2010

    • Author(s)
      Togao O, Yoshiura T, Nakao T, Nabeyama M, Sanematsu H, Nakagawa A, Noguchi T, Hiwatashi A, Yamashita K, Nagao E, Kanba S, Honda H
    • Journal Title

      PsychiatryRes

      Volume: 184 Issue: 1 Pages: 29-37

    • DOI

      10.1016/j.pscychresns.2010.06.011

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Neural correlation between brain activities and clinical improvement in patients with checking symptom and patients with washing symptom in obsessive-compulsive disorder: an fMRI symptom provocation study2012

    • Author(s)
      Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Isomura K, Nakagawa A, Kanba S
    • Organizer
      Europian Association for Behavioural and Cognitive Therapies
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2012 Final Research Report
  • [Presentation] Neural correlation between brain activities and clinical improvement in patients with checking symptom and patients with washing symptom in obsessive-compulsive disorder: an fMRI symptom provocation study.2012

    • Author(s)
      Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Isomura K, Nakagawa A, Kanba S
    • Organizer
      Europian Association for Behavioural and Cognitive Therapies
    • Place of Presentation
      Geneva, Switzerland
    • Related Report
      2012 Annual Research Report
  • [Presentation] Differential neural correlates in obsessive-compulsive disorder patients with checking vs. those with washing symptoms: an fMRI symptom provocation study.2012

    • Author(s)
      Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Kayoko Isomura K, Nakagawa A, Kanba S
    • Organizer
      World Psychiatric Association International Congress
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication.2012

    • Author(s)
      Nakao T, Radua J, Rubia K, Mataix-Cols D
    • Organizer
      World Psychiatric Association International Congress
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2012 Annual Research Report
  • [Presentation] Correlation between regional gray matter volume and symptomatic dimension in OCD.2012

    • Author(s)
      岡田佳代, 中尾智博, 實松寛晋, 村山桂太郎, 本田慎一, 富田真弓, 五位塚和也, 神庭重信
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Association analysis of the serotonin transporter (SLC6A4) genepolymorphisms with OCD.2012

    • Author(s)
      本田慎一, 中尾智博, 光安博志, 後藤玲央, 實松寛晋, 村山桂太郎, 岡田佳代, 富田真弓, 五位塚和也, 川嵜弘詔, 神庭重信
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Regional gray matter volume abnormalities in obsessive-compulsive disorder : A voxel-based morphometry study2011

    • Author(s)
      Nakao T.
    • Organizer
      10th World Congress of Biological Psychiatry
    • Place of Presentation
      Prague, Czech Republic
    • Related Report
      2011 Annual Research Report
  • [Presentation] 強迫性障害診断・治療ガイドラインの検証および拡充につながる遺伝子研究2010

    • Author(s)
      川嵜弘詔、實松寛晋、光安博志
    • Organizer
      厚生労働省精神神経疾患研究開発費 児童思春期強迫性障害診断・治療ガイドラインの検証及び拡充に関する研究 班会議
    • Place of Presentation
      東京都、アルカディア市ヶ谷
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発症時期別にみた強迫性障害患者の神経心理機能及び脳機能画像2010

    • Author(s)
      中尾智博、實松寛晋、吉浦敬
    • Organizer
      第30回日本精神科診断学会
    • Place of Presentation
      福岡市、九州大学百年講堂
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] OCD関連障害に対する神経画像解析

    • Author(s)
      中尾智博, 岡田佳代
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の精神疾患治療指針2012

    • Author(s)
      川嵜弘詔, 光安博志
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 強迫性障害の脳画像. TEXT 精神医学2012

    • Author(s)
      中尾智博
    • Total Pages
      273
    • Publisher
      南山堂
    • Related Report
      2012 Final Research Report
  • [Book] 強迫性障害. 今日の精神疾患治療指針2012

    • Author(s)
      實松寛晋
    • Publisher
      医学書院
    • Related Report
      2012 Final Research Report
  • [Book] 強迫性障害のための身につける行動療法2012

    • Author(s)
      中尾智博,飯倉康郎, 芝田寿美男, 中川彰子編
    • Total Pages
      19
    • Publisher
      岩崎学術出版社
    • Related Report
      2012 Annual Research Report
  • [Book] TEXT精神医学2012

    • Author(s)
      中尾智博
    • Total Pages
      1
    • Publisher
      南山堂
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の精神疾患治療指針2012

    • Author(s)
      實松寛晋
    • Total Pages
      8
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] 今日の精神疾患治療指針(樋口輝彦他編)2012

    • Author(s)
      川嵜弘詔, 光安博志
    • Total Pages
      5
    • Publisher
      医学書院
    • Related Report
      2012 Annual Research Report
  • [Book] STEP-BD. リンケージ解析[連鎖解析]. 現代精神医学事典2011

    • Author(s)
      川嵜弘詔
    • Publisher
      弘文社
    • Related Report
      2012 Final Research Report
  • [Book] 強迫性障害. 条件づけ. 現代精神医学事典2011

    • Author(s)
      中尾智博
    • Publisher
      弘文堂
    • Related Report
      2012 Final Research Report
  • [Book] 強迫性緩慢. 深部脳刺激[DBS] . 現代精神医学事典2011

    • Author(s)
      村山桂太郎
    • Publisher
      弘文堂
    • Related Report
      2012 Final Research Report
  • [Book] 強迫性障害.現代精神医学事典(加藤敏・神庭重信・中谷陽二ら編)2011

    • Author(s)
      中尾智博
    • Total Pages
      2
    • Publisher
      弘文堂
    • Related Report
      2011 Annual Research Report
  • [Book] 大脳基底核と強迫性・衝動性2010

    • Author(s)
      中尾智博, 村山桂太郎
    • Publisher
      中山書店
    • Related Report
      2012 Final Research Report
  • [Book] OCD の基礎知識 生物学的機序-治療的な観点から-2010

    • Author(s)
      中尾智博
    • Publisher
      星和書店
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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