Biological study of obsessive-compulsive disorder using brain imaging and the molecular genetics

• Project/Area Number: 22591262
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: KAWASAKI Hiroaki 九州大学, 医学研究院, 准教授 (50224762)
• Co-Investigator(Kenkyū-buntansha): NAKAO Tomohiro 九州大学, 大学病院, 講師 (50423554) ; MITUYASU Hiroshi 九州大学, 大学病院, 助教 (00533176) ; SANEMATSU Hirokuni 九州大学, 大学病院, 助教 (30588116) ; YOSHIURA Takashi 九州大学, 医学研究科, 准教授 (40322747)
• Co-Investigator(Renkei-kenkyūsha): KANBA Shigenobu 九州大学, 医学研究科, 教授 (50195187) ; NAKAGAWA Akiko 千葉大学, 医学研究科, 教授 (70253424)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 臨床精神分子遺伝学 / 強迫性障害 / MRI / 遺伝子 / セロトニントランスポーター / 画像解析 / 神経画像 / 症状亜型 / 中間表現型

Research Abstract

Eighty-nine obsessive and compulsive disorder (OCD) patients and 89 healthy controls were genotyped with L- and s- types polymorphisms of 5HTT -LPR. As a result, OCD patients with current and/or past comorbid depression had a statistically higher frequency of the L-allele. The result suggested that the L-allele might be associated with the comorbidity depression with OCD.Magnetic resonance imaging examinations of 37 OCD patients and 37 healthy controls (HCs) were carried out. W e found significant reductions in right posterior cingulate cortexand some other areas in the OCD patients compared to healthy controls (HCs). In addition, we found specific correlations between the type of the obsession symptom and the volume of the specific area of the brain. The pathophysiology of OCD may involve widely distributed neural systems. Moreover, there are distinct correlations among symptomatic dimensions and structural abnormalities.

Research Products

• [Journal Article] Meta-analysis of Functional Magnetic Resonance Imaging Studies of Inhibition and Attention in Attention-deficit/ Hyperactivity Disorder: Exploring Task-Specific, Stimulant Medication, and Age Effects. (2013)
  • Author(s): Hart H, Radua J, Nakao T, Mataix-Cols D, Rubia K
  • Journal Title: JAMA Psychiatry Volume: 70(2) Issue: 2 Pages: 185-198
  • DOI: 10.1001/jamapsychiatry.2013.277
  • Peer Reviewed
• [Journal Article] Differential neural network of checking versus washing symptoms in obsessive-compulsivedisorder (2012)
  • Author(s): Murayama K, Nakao T, Sanematsu H, Okada K, Yoshiura T, Tomita M, Masuda Y, Isomura K, Nakagawa A, Kanba S
  • Journal Title: PROGRESS IN NEUROPSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY Volume: 40巻 Pages: 160-6
  • DOI: 10.1016/j.pnpbp.2012.09.002
  • Peer Reviewed
• [Journal Article] A placebo-controlled, double-blind study of the efficacy and safety of aripiprazole for the treatment of acute manic ormixed episodes in Asian patients with bipolar I disorder (the AMAZE study) (2012)
  • Author(s): Kanba S, Kawasaki H, Ishigooka J, Sakamoto K, Kinoshita T, Kuroki T
  • Journal Title: World J Biol Psychiatry Volume: Epub ahead of print Issue: 2 Pages: 1-9
  • DOI: 10.3109/15622975.2012.669047
  • Peer Reviewed
• [Journal Article] Nominal association between a polymorphism in DGKH and bipolardisorder detected in a meta-analysis of East Asian case-control samples (2011)
  • Author(s): Takata A, Kawasaki H, Iwayama Y, Yamada K, Gotoh L, Mitsuyasu H, Miura T, Kato T,Yoshikawa T, Kanba S
  • Journal Title: Psychiatry Clin Neurosci Volume: 65(3) Issue: 3 Pages: 280-5
  • DOI: 10.1111/j.1440-1819.2011.02193.x
  • Peer Reviewed
• [Journal Article] fMRI of patients with social anxiety disorder during a social situation task (2011)
  • Author(s): Nakao T, Sanematsu H, Yoshiura T, Togao O, Murayama K, Tomita M, Masuda Y, Kanba S
  • Journal Title: Neurosci Res Volume: 69 Issue: 1 Pages: 67-72
  • DOI: 10.1016/j.neures.2010.09.008
  • NAID: 10028190256
  • Peer Reviewed
• [Journal Article] Gray Matter Volume Abnormalities in ADHD : Voxel-Based Meta-Analysis Exploring the Effects of Age and Stimulant Medication (2011)
  • Author(s): Nakao T.
  • Journal Title: Am J Psychiatry Volume: 168 Pages: 1154-1163
  • Peer Reviewed
• [Journal Article] OCDの病態仮説と治療理論 (2011)
  • Author(s): 中尾智博
  • Journal Title: 精神神経誌 Volume: 113 Pages: 26-27
  • NAID: 10028060411
• [Journal Article] Predictors of treatment response to fluvoxamine in obsessive-compulsive disorder: An fMRI study (2010)
  • Author(s): Sanematsu H, Nakao T, Yoshiura T, Nabeyama M, Togao O, Tomita M, Masuda Y, Yoshioka K, Nakatani E, Nakagawa A, Kanba S
  • Journal Title: J Psychiatr Res Volume: 44 Issue: 4 Pages: 193-200
  • DOI: 10.1016/j.jpsychires.2009.08.007
  • NAID: 120005289467
  • Peer Reviewed
• [Journal Article] Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: A voxel-based morphometry study (2010)
  • Author(s): Togao O, Yoshiura T, Nakao T, Nabeyama M, Sanematsu H, Nakagawa A, Noguchi T, Hiwatashi A, Yamashita K, Nagao E, Kanba S, Honda H
  • Journal Title: PsychiatryRes Volume: 184 Issue: 1 Pages: 29-37
  • DOI: 10.1016/j.pscychresns.2010.06.011
  • Peer Reviewed
• [Presentation] Neural correlation between brain activities and clinical improvement in patients with checking symptom and patients with washing symptom in obsessive-compulsive disorder: an fMRI symptom provocation study (2012)
  • Author(s): Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Isomura K, Nakagawa A, Kanba S
  • Organizer: Europian Association for Behavioural and Cognitive Therapies
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Neural correlation between brain activities and clinical improvement in patients with checking symptom and patients with washing symptom in obsessive-compulsive disorder: an fMRI symptom provocation study. (2012)
  • Author(s): Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Isomura K, Nakagawa A, Kanba S
  • Organizer: Europian Association for Behavioural and Cognitive Therapies
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Differential neural correlates in obsessive-compulsive disorder patients with checking vs. those with washing symptoms: an fMRI symptom provocation study. (2012)
  • Author(s): Murayama K, Nakao T, Sanenatsu H, Okada K, Yoshiura T, Tomita M, Matsuda Y, Kayoko Isomura K, Nakagawa A, Kanba S
  • Organizer: World Psychiatric Association International Congress
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Gray matter volume abnormalities in ADHD: voxel-based meta-analysis exploring the effects of age and stimulant medication. (2012)
  • Author(s): Nakao T, Radua J, Rubia K, Mataix-Cols D
  • Organizer: World Psychiatric Association International Congress
  • Place of Presentation: Prague, Czech Republic
• [Presentation] Correlation between regional gray matter volume and symptomatic dimension in OCD. (2012)
  • Author(s): 岡田佳代, 中尾智博, 實松寛晋, 村山桂太郎, 本田慎一, 富田真弓, 五位塚和也, 神庭重信
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] Association analysis of the serotonin transporter (SLC6A4) genepolymorphisms with OCD. (2012)
  • Author(s): 本田慎一, 中尾智博, 光安博志, 後藤玲央, 實松寛晋, 村山桂太郎, 岡田佳代, 富田真弓, 五位塚和也, 川嵜弘詔, 神庭重信
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Presentation] Regional gray matter volume abnormalities in obsessive-compulsive disorder : A voxel-based morphometry study (2011)
  • Author(s): Nakao T.
  • Organizer: 10th World Congress of Biological Psychiatry
  • Place of Presentation: Prague, Czech Republic
• [Presentation] 強迫性障害診断・治療ガイドラインの検証および拡充につながる遺伝子研究 (2010)
  • Author(s): 川嵜弘詔、實松寛晋、光安博志
  • Organizer: 厚生労働省精神神経疾患研究開発費 児童思春期強迫性障害診断・治療ガイドラインの検証及び拡充に関する研究 班会議
  • Place of Presentation: 東京都、アルカディア市ヶ谷
  • Year and Date: 2010-12-02
• [Presentation] 発症時期別にみた強迫性障害患者の神経心理機能及び脳機能画像 (2010)
  • Author(s): 中尾智博、實松寛晋、吉浦敬
  • Organizer: 第30回日本精神科診断学会
  • Place of Presentation: 福岡市、九州大学百年講堂
  • Year and Date: 2010-11-12
• [Presentation] OCD関連障害に対する神経画像解析
  • Author(s): 中尾智博, 岡田佳代
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Book] 今日の精神疾患治療指針 (2012)
  • Author(s): 川嵜弘詔, 光安博志
  • Publisher: 医学書院
• [Book] 強迫性障害の脳画像. TEXT 精神医学 (2012)
  • Author(s): 中尾智博
  • Total Pages: 273
  • Publisher: 南山堂
• [Book] 強迫性障害. 今日の精神疾患治療指針 (2012)
  • Author(s): 實松寛晋
  • Publisher: 医学書院
• [Book] 強迫性障害のための身につける行動療法 (2012)
  • Author(s): 中尾智博,飯倉康郎, 芝田寿美男, 中川彰子編
  • Total Pages: 19
  • Publisher: 岩崎学術出版社
• [Book] TEXT精神医学 (2012)
  • Author(s): 中尾智博
  • Total Pages: 1
  • Publisher: 南山堂
• [Book] 今日の精神疾患治療指針 (2012)
  • Author(s): 實松寛晋
  • Total Pages: 8
  • Publisher: 医学書院
• [Book] 今日の精神疾患治療指針(樋口輝彦他編) (2012)
  • Author(s): 川嵜弘詔, 光安博志
  • Total Pages: 5
  • Publisher: 医学書院
• [Book] STEP-BD. リンケージ解析[連鎖解析]. 現代精神医学事典 (2011)
  • Author(s): 川嵜弘詔
  • Publisher: 弘文社
• [Book] 強迫性障害. 条件づけ. 現代精神医学事典 (2011)
  • Author(s): 中尾智博
  • Publisher: 弘文堂
• [Book] 強迫性緩慢. 深部脳刺激[DBS] . 現代精神医学事典 (2011)
  • Author(s): 村山桂太郎
  • Publisher: 弘文堂
• [Book] 強迫性障害.現代精神医学事典(加藤敏・神庭重信・中谷陽二ら編) (2011)
  • Author(s): 中尾智博
  • Total Pages: 2
  • Publisher: 弘文堂
• [Book] 大脳基底核と強迫性・衝動性 (2010)
  • Author(s): 中尾智博, 村山桂太郎
  • Publisher: 中山書店
• [Book] OCD の基礎知識 生物学的機序-治療的な観点から- (2010)
  • Author(s): 中尾智博
  • Publisher: 星和書店